KR20010075063A - 건조 분말 활성제의 폐 전달 - Google Patents

건조 분말 활성제의 폐 전달 Download PDF

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Publication number
KR20010075063A
KR20010075063A KR1020017003208A KR20017003208A KR20010075063A KR 20010075063 A KR20010075063 A KR 20010075063A KR 1020017003208 A KR1020017003208 A KR 1020017003208A KR 20017003208 A KR20017003208 A KR 20017003208A KR 20010075063 A KR20010075063 A KR 20010075063A
Authority
KR
South Korea
Prior art keywords
active agent
particles
hygroscopic growth
growth inhibitor
alveoli
Prior art date
Application number
KR1020017003208A
Other languages
English (en)
Korean (ko)
Inventor
클라크앤드류
쿠오메이-창
랄로세실리
알도스베리존
Original Assignee
추후보정
인헤일 테라퓨틱 시스템즈 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 추후보정, 인헤일 테라퓨틱 시스템즈 인크. filed Critical 추후보정
Publication of KR20010075063A publication Critical patent/KR20010075063A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
KR1020017003208A 1998-09-14 1999-09-13 건조 분말 활성제의 폐 전달 KR20010075063A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10016398P 1998-09-14 1998-09-14
US60/100,163 1998-09-14
PCT/US1999/021109 WO2000015262A1 (en) 1998-09-14 1999-09-13 Dry powder active agent pulmonary delivery

Publications (1)

Publication Number Publication Date
KR20010075063A true KR20010075063A (ko) 2001-08-09

Family

ID=22278404

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017003208A KR20010075063A (ko) 1998-09-14 1999-09-13 건조 분말 활성제의 폐 전달

Country Status (44)

Country Link
EP (1) EP1117442A1 (xx)
JP (1) JP2002524535A (xx)
KR (1) KR20010075063A (xx)
CN (1) CN1317977A (xx)
AP (1) AP1374A (xx)
AR (1) AR022090A1 (xx)
AU (1) AU753014B2 (xx)
BG (1) BG105430A (xx)
BR (1) BR9913722A (xx)
CA (1) CA2343920A1 (xx)
CO (1) CO5130023A1 (xx)
CZ (1) CZ2001829A3 (xx)
DZ (1) DZ2892A1 (xx)
EA (1) EA003476B1 (xx)
EE (1) EE200100151A (xx)
GE (1) GEP20043257B (xx)
GT (1) GT199900156A (xx)
HK (1) HK1042231A1 (xx)
HN (1) HN1999000159A (xx)
HR (1) HRP20010189A2 (xx)
HU (1) HUP0103837A3 (xx)
ID (1) ID28845A (xx)
IL (2) IL141562A0 (xx)
IS (1) IS5878A (xx)
LT (1) LT4897B (xx)
LV (1) LV12658B (xx)
MA (1) MA25590A1 (xx)
MY (1) MY129282A (xx)
NO (1) NO20011251L (xx)
NZ (1) NZ510168A (xx)
OA (1) OA11781A (xx)
PA (1) PA8481901A1 (xx)
PE (1) PE20001061A1 (xx)
PL (1) PL195574B1 (xx)
SA (1) SA99200718B1 (xx)
SK (1) SK3442001A3 (xx)
TN (1) TNSN99173A1 (xx)
TR (1) TR200101182T2 (xx)
TW (1) TWI226248B (xx)
UA (1) UA76085C2 (xx)
UY (1) UY25711A1 (xx)
WO (1) WO2000015262A1 (xx)
YU (1) YU24201A (xx)
ZA (1) ZA200101995B (xx)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9617352B2 (en) 2005-10-26 2017-04-11 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
US10117940B2 (en) 2004-04-23 2018-11-06 Cydex Pharmaceuticals, Inc. DPI formulation containing sulfoalkyl ether cyclodextrin

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US6630121B1 (en) 1999-06-09 2003-10-07 The Regents Of The University Of Colorado Supercritical fluid-assisted nebulization and bubble drying
US6475468B2 (en) * 2001-02-15 2002-11-05 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
EP1392262A1 (en) * 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
EG24184A (en) 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
US7351844B2 (en) 2002-02-25 2008-04-01 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
AU2003232081B2 (en) * 2002-07-03 2009-02-05 Brandeis University Central airway administration for systemic delivery of therapeutics
ES2280835T3 (es) * 2002-12-19 2007-09-16 Pharmacia Corporation Formulacion no higroscopica que comprende un farmaco higroscopico.
DE10338403A1 (de) * 2003-08-18 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverformulierung, enthaltend den CGRP-Antagonisten 1-[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl]-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyrindinyl)-piperazin, Verfahren zu dessen Herstellung sowie dessen Verwendung als Inhalativum
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
JP2008531582A (ja) 2005-02-24 2008-08-14 ディフュージョン・ファーマシューティカルズ・エルエルシー トランスカロテノイド、それらの合成、配合、および使用
RU2007137121A (ru) * 2005-03-09 2009-04-20 Оно Фармасьютикал Ко., Лтд. (Jp) Частица и препарат, содержащий указанную частицу
HUE035181T2 (hu) 2005-10-26 2018-05-02 Cydex Pharmaceuticals Inc Szulfoalkil-éter-ciklodextrin kompozíciók és eljárások elõállításukra
US20080035143A1 (en) * 2006-08-14 2008-02-14 Sievers Robert E Human-powered dry powder inhaler and dry powder inhaler compositions
KR20090081407A (ko) * 2006-10-25 2009-07-28 다이닛본 스미토모 세이야꾸 가부시끼가이샤 고결 방지 과립상 제제
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
EA200970944A1 (ru) 2007-04-13 2010-06-30 Диффьюжн Фармасьютикалз Ллс Применение биполярных транскаротиноидов в качестве предварительного лечения при лечении заболевания периферических сосудов
MX2010004803A (es) 2007-10-31 2010-09-09 Diffusion Pharmaceuticals Llc Una nueva clase de composiciones terapeuticas que mejoran la difusion de moleculas pequeñas.
TR201802619T4 (tr) * 2009-05-20 2018-03-21 Aeras Kararlı, sprey ile kurutulmuş, immunojen, viral bileşimler.
CA2765697C (en) 2009-06-22 2019-11-12 Diffusion Pharmaceuticals Llc Diffusion enhancing compounds and their use alone or with thrombolytics
EP2575487B1 (en) 2010-06-02 2017-10-18 Diffusion Pharmaceuticals Llc Oral formulations of bipolar trans carotenoids
IN2014MN02359A (xx) 2012-05-03 2015-08-14 Janssen R & D Ireland
BR112015010601B1 (pt) * 2012-11-09 2022-07-19 Civitas Therapeutics, Inc. Composição farmacêutica e uso da composição
WO2015042352A1 (en) * 2013-09-20 2015-03-26 Virginia Commonwealth University Delivery of particles using hygroscopic excipients
CA2965759C (en) 2014-10-31 2023-12-12 Glaxosmithkline Intellectual Property Development Limited Powdered polypeptides with decreased disulfide impurities comprising divalent cationic materials
KR20230014850A (ko) 2016-03-24 2023-01-30 디퓨젼 파마슈티컬즈 엘엘씨 암을 치료하기 위한, 화학 요법 및 방사선 요법과의 양극성 트랜스 카로티노이드의 용도

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155573A (en) * 1958-05-06 1964-11-03 Benger Lab Ltd Inhalant composition and method of making same
CA2115065C (en) * 1992-06-12 2000-10-03 Kiyoyuki Sakon Ultrafine particle powder for inhalation and method for production thereof
US6524557B1 (en) * 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
CA2277801C (en) * 1997-01-16 2002-10-15 Massachusetts Institute Of Technology Preparation of particles for inhalation
US6086376A (en) * 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10117940B2 (en) 2004-04-23 2018-11-06 Cydex Pharmaceuticals, Inc. DPI formulation containing sulfoalkyl ether cyclodextrin
US10668160B2 (en) 2004-04-23 2020-06-02 Cydex Pharmaceuticals, Inc. DPI formulation containing sulfoalkyl ether cyclodextrin
US11464862B2 (en) 2004-04-23 2022-10-11 Cydex Pharmaceuticals, Inc. DPI formulation containing sulfoalkyl ether cyclodextrin
US9617352B2 (en) 2005-10-26 2017-04-11 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
US10202468B2 (en) 2005-10-26 2019-02-12 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
US10703826B2 (en) 2005-10-26 2020-07-07 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof

Also Published As

Publication number Publication date
HUP0103837A2 (hu) 2002-05-29
PL195574B1 (pl) 2007-10-31
CN1317977A (zh) 2001-10-17
ZA200101995B (en) 2002-03-11
NO20011251D0 (no) 2001-03-13
TWI226248B (en) 2005-01-11
LT2001021A (en) 2001-11-26
NZ510168A (en) 2003-09-26
CO5130023A1 (es) 2002-02-27
ID28845A (id) 2001-07-05
IL141562A (en) 2007-07-24
AU753014B2 (en) 2002-10-03
SA99200718B1 (ar) 2006-11-04
CZ2001829A3 (cs) 2001-09-12
HK1042231A1 (zh) 2002-08-09
PE20001061A1 (es) 2000-10-08
JP2002524535A (ja) 2002-08-06
HRP20010189A2 (en) 2005-04-30
EP1117442A1 (en) 2001-07-25
IS5878A (is) 2001-03-05
CA2343920A1 (en) 2000-03-23
AP1374A (en) 2005-02-28
AR022090A1 (es) 2002-09-04
PA8481901A1 (es) 2002-04-25
DZ2892A1 (fr) 2003-12-15
MY129282A (en) 2007-03-30
EA200100300A1 (ru) 2001-10-22
GEP20043257B (en) 2004-06-25
HUP0103837A3 (en) 2002-11-28
OA11781A (en) 2005-07-26
AP2001002093A0 (en) 2001-03-31
AU6039799A (en) 2000-04-03
YU24201A (sh) 2003-08-29
EE200100151A (et) 2002-06-17
HN1999000159A (es) 1999-11-11
BR9913722A (pt) 2001-05-29
UY25711A1 (es) 1999-11-17
LV12658A (lv) 2001-05-20
SK3442001A3 (en) 2001-11-06
PL346768A1 (en) 2002-02-25
MA25590A1 (fr) 2002-12-31
TR200101182T2 (tr) 2001-09-21
LV12658B (lv) 2001-09-20
GT199900156A (es) 2001-03-07
TNSN99173A1 (fr) 2005-11-10
IL141562A0 (en) 2002-03-10
NO20011251L (no) 2001-04-17
EA003476B1 (ru) 2003-06-26
WO2000015262A1 (en) 2000-03-23
BG105430A (en) 2001-12-29
LT4897B (lt) 2002-02-25
UA76085C2 (en) 2006-07-17

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Legal Events

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A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application
J201 Request for trial against refusal decision
J301 Trial decision

Free format text: TRIAL DECISION FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20060720

Effective date: 20070726