AP1374A - Aerosolizable particles resistant to hygroscopic growth. - Google Patents

Aerosolizable particles resistant to hygroscopic growth. Download PDF

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Publication number
AP1374A
AP1374A APAP/P/2001/002093A AP2001002093A AP1374A AP 1374 A AP1374 A AP 1374A AP 2001002093 A AP2001002093 A AP 2001002093A AP 1374 A AP1374 A AP 1374A
Authority
AP
ARIPO
Prior art keywords
particles
active agent
hygroscopic
growth inhibitor
hygroscopic growth
Prior art date
Application number
APAP/P/2001/002093A
Other languages
English (en)
Other versions
AP2001002093A0 (en
Inventor
Andrew Clark
Mei-Chang Kuo
Cecily Lalor
Barry John Aldous
Original Assignee
Inhale Therapeutic Syst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhale Therapeutic Syst filed Critical Inhale Therapeutic Syst
Publication of AP2001002093A0 publication Critical patent/AP2001002093A0/xx
Application granted granted Critical
Publication of AP1374A publication Critical patent/AP1374A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
APAP/P/2001/002093A 1998-09-14 1999-09-13 Aerosolizable particles resistant to hygroscopic growth. AP1374A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10016398P 1998-09-14 1998-09-14
PCT/US1999/021109 WO2000015262A1 (en) 1998-09-14 1999-09-13 Dry powder active agent pulmonary delivery

Publications (2)

Publication Number Publication Date
AP2001002093A0 AP2001002093A0 (en) 2001-03-31
AP1374A true AP1374A (en) 2005-02-28

Family

ID=22278404

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/2001/002093A AP1374A (en) 1998-09-14 1999-09-13 Aerosolizable particles resistant to hygroscopic growth.

Country Status (44)

Country Link
EP (1) EP1117442A1 (xx)
JP (1) JP2002524535A (xx)
KR (1) KR20010075063A (xx)
CN (1) CN1317977A (xx)
AP (1) AP1374A (xx)
AR (1) AR022090A1 (xx)
AU (1) AU753014B2 (xx)
BG (1) BG105430A (xx)
BR (1) BR9913722A (xx)
CA (1) CA2343920A1 (xx)
CO (1) CO5130023A1 (xx)
CZ (1) CZ2001829A3 (xx)
DZ (1) DZ2892A1 (xx)
EA (1) EA003476B1 (xx)
EE (1) EE200100151A (xx)
GE (1) GEP20043257B (xx)
GT (1) GT199900156A (xx)
HK (1) HK1042231A1 (xx)
HN (1) HN1999000159A (xx)
HR (1) HRP20010189A2 (xx)
HU (1) HUP0103837A3 (xx)
ID (1) ID28845A (xx)
IL (2) IL141562A0 (xx)
IS (1) IS5878A (xx)
LT (1) LT4897B (xx)
LV (1) LV12658B (xx)
MA (1) MA25590A1 (xx)
MY (1) MY129282A (xx)
NO (1) NO20011251L (xx)
NZ (1) NZ510168A (xx)
OA (1) OA11781A (xx)
PA (1) PA8481901A1 (xx)
PE (1) PE20001061A1 (xx)
PL (1) PL195574B1 (xx)
SA (1) SA99200718B1 (xx)
SK (1) SK3442001A3 (xx)
TN (1) TNSN99173A1 (xx)
TR (1) TR200101182T2 (xx)
TW (1) TWI226248B (xx)
UA (1) UA76085C2 (xx)
UY (1) UY25711A1 (xx)
WO (1) WO2000015262A1 (xx)
YU (1) YU24201A (xx)
ZA (1) ZA200101995B (xx)

Families Citing this family (29)

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JP4874483B2 (ja) 1999-06-09 2012-02-15 ロバート イー． シーバース 超臨界流体補助ネブライゼーション及びバブル乾燥
US6475468B2 (en) * 2001-02-15 2002-11-05 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
CA2446904A1 (en) * 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
AU2003215396B2 (en) 2002-02-25 2010-04-08 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
JP2006513139A (ja) * 2002-07-03 2006-04-20 ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド 治療薬の全身性送達のための中央部気道投与
ES2280835T3 (es) * 2002-12-19 2007-09-16 Pharmacia Corporation Formulacion no higroscopica que comprende un farmaco higroscopico.
DE10338403A1 (de) * 2003-08-18 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverformulierung, enthaltend den CGRP-Antagonisten 1-[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl]-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyrindinyl)-piperazin, Verfahren zu dessen Herstellung sowie dessen Verwendung als Inhalativum
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
EP2708225B1 (en) 2004-04-23 2018-12-26 CyDex Pharmaceuticals, Inc. DPI Formulation Containing Sulfoalkyl Ether Cyclodextrin
EA017982B1 (ru) 2005-02-24 2013-04-30 ДИФФЬЮЖН ФАРМАСЬЮТИКАЛЗ ЭлЭлСи Фармацевтическая композиция на основе транскаротиноидов и способы лечения опухоли
WO2006095788A1 (ja) * 2005-03-09 2006-09-14 Ono Pharmaceutical Co., Ltd. 粒子およびその粒子を含有する製剤
KR101152886B1 (ko) 2005-10-26 2012-07-09 사이덱스 파마슈티칼스, 인크. 설포알킬 에테르 시클로덱스트린 조성물 및 그의 제조 방법
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
US20100269819A1 (en) * 2006-08-14 2010-10-28 Sievers Robert E Human Powered Dry Powder Inhaler and Dry Powder Inhaler Compositions
WO2008050847A1 (fr) * 2006-10-25 2008-05-02 Dainippon Sumitomo Pharma Co., Ltd. Préparation granulaire non agglutinante
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
WO2008136900A1 (en) 2007-04-13 2008-11-13 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
US8206751B2 (en) 2007-10-31 2012-06-26 Diffusion Pharmaceuticals Llc Class of therapeutics that enhance small molecule diffusion
PL2432502T3 (pl) 2009-05-20 2018-05-30 Aeras Trwałe, suszone rozpyłowo, immunogenne kompozycje wirusowe
KR101782023B1 (ko) 2009-06-22 2017-10-23 디퓨젼 파마슈티컬즈 엘엘씨 확산 촉진 화합물 및 그 화합물 단독 또는 혈전 용해제와 합쳐진 화합물의 용도
CN103124498A (zh) 2010-06-02 2013-05-29 扩散药品有限公司 双极性反式类胡萝卜素的口服制剂
BR112014026957A8 (pt) 2012-05-03 2018-01-16 Janssen R&D Ireland micropartícula, composição compreendendo a mesma, seu uso e sistema de distribuição nasal relacionados ao tratamento de infecções do trato respiratório superior
WO2014074797A1 (en) * 2012-11-09 2014-05-15 Civitas Therapeutics, Inc. Ultra low density pulmonary powders
WO2015042352A1 (en) * 2013-09-20 2015-03-26 Virginia Commonwealth University Delivery of particles using hygroscopic excipients
DK3212212T3 (da) 2014-10-31 2020-12-21 Univ Monash Pulverformulering
CA3018550A1 (en) 2016-03-24 2017-09-28 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155573A (en) * 1958-05-06 1964-11-03 Benger Lab Ltd Inhalant composition and method of making same
EP0611567A1 (en) * 1992-06-12 1994-08-24 Teijin Limited Ultrafine powder for inhalation and production thereof
WO1996019197A1 (en) * 1994-12-22 1996-06-27 Astra Aktiebolag Aerosol formulations of peptides and proteins
WO1998031346A1 (en) * 1997-01-16 1998-07-23 Massachusetts Institute Of Technology Preparation of particles for inhalation
WO1999038493A1 (en) * 1998-01-30 1999-08-05 Rtp Pharma Inc. Microparticle inhalation formulations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155573A (en) * 1958-05-06 1964-11-03 Benger Lab Ltd Inhalant composition and method of making same
EP0611567A1 (en) * 1992-06-12 1994-08-24 Teijin Limited Ultrafine powder for inhalation and production thereof
WO1996019197A1 (en) * 1994-12-22 1996-06-27 Astra Aktiebolag Aerosol formulations of peptides and proteins
WO1998031346A1 (en) * 1997-01-16 1998-07-23 Massachusetts Institute Of Technology Preparation of particles for inhalation
WO1999038493A1 (en) * 1998-01-30 1999-08-05 Rtp Pharma Inc. Microparticle inhalation formulations

Also Published As

Publication number Publication date
AU753014B2 (en) 2002-10-03
YU24201A (sh) 2003-08-29
BR9913722A (pt) 2001-05-29
HRP20010189A2 (en) 2005-04-30
WO2000015262A1 (en) 2000-03-23
EE200100151A (et) 2002-06-17
LV12658B (lv) 2001-09-20
CN1317977A (zh) 2001-10-17
MA25590A1 (fr) 2002-12-31
CZ2001829A3 (cs) 2001-09-12
IL141562A0 (en) 2002-03-10
ID28845A (id) 2001-07-05
TNSN99173A1 (fr) 2005-11-10
KR20010075063A (ko) 2001-08-09
CA2343920A1 (en) 2000-03-23
PL195574B1 (pl) 2007-10-31
AU6039799A (en) 2000-04-03
PE20001061A1 (es) 2000-10-08
HUP0103837A3 (en) 2002-11-28
IL141562A (en) 2007-07-24
PA8481901A1 (es) 2002-04-25
MY129282A (en) 2007-03-30
UY25711A1 (es) 1999-11-17
OA11781A (en) 2005-07-26
NO20011251D0 (no) 2001-03-13
HK1042231A1 (zh) 2002-08-09
HN1999000159A (es) 1999-11-11
GT199900156A (es) 2001-03-07
NO20011251L (no) 2001-04-17
AR022090A1 (es) 2002-09-04
AP2001002093A0 (en) 2001-03-31
DZ2892A1 (fr) 2003-12-15
PL346768A1 (en) 2002-02-25
SK3442001A3 (en) 2001-11-06
LT2001021A (en) 2001-11-26
IS5878A (is) 2001-03-05
HUP0103837A2 (hu) 2002-05-29
NZ510168A (en) 2003-09-26
EA200100300A1 (ru) 2001-10-22
LV12658A (lv) 2001-05-20
LT4897B (lt) 2002-02-25
UA76085C2 (en) 2006-07-17
GEP20043257B (en) 2004-06-25
JP2002524535A (ja) 2002-08-06
BG105430A (en) 2001-12-29
TR200101182T2 (tr) 2001-09-21
EA003476B1 (ru) 2003-06-26
SA99200718B1 (ar) 2006-11-04
CO5130023A1 (es) 2002-02-27
ZA200101995B (en) 2002-03-11
EP1117442A1 (en) 2001-07-25
TWI226248B (en) 2005-01-11

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