GC0000151A - 2-(3,5-Bis-trifluoromethyl-phenyl)-n-methyl-n-(6-morpholin-4-o-tolyl-pyridin-3-yl)-isobutyramide. - Google Patents

2-(3,5-Bis-trifluoromethyl-phenyl)-n-methyl-n-(6-morpholin-4-o-tolyl-pyridin-3-yl)-isobutyramide.

Info

Publication number
GC0000151A
GC0000151A GCP20001052A GC0000151A GC 0000151 A GC0000151 A GC 0000151A GC P20001052 A GCP20001052 A GC P20001052A GC 0000151 A GC0000151 A GC 0000151A
Authority
GC
Cooperation Council for the Arab states of the Gulf
Prior art keywords
isobutyramide
morpholin
pyridin
tolyl
trifluoromethyl
Prior art date
Application number
Other languages
English (en)
Inventor
Theresa Maria Ballard
Guy Andrew Higgins
Torsten Hoffmann
Sonia Maria Poli
Andrew Sleight
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of GC0000151A publication Critical patent/GC0000151A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
GCP20001052 1999-11-29 2000-11-26 2-(3,5-Bis-trifluoromethyl-phenyl)-n-methyl-n-(6-morpholin-4-o-tolyl-pyridin-3-yl)-isobutyramide. GC0000151A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99123685 1999-11-29

Publications (1)

Publication Number Publication Date
GC0000151A true GC0000151A (en) 2005-06-29

Family

ID=8239481

Family Applications (1)

Application Number Title Priority Date Filing Date
GCP20001052 GC0000151A (en) 1999-11-29 2000-11-26 2-(3,5-Bis-trifluoromethyl-phenyl)-n-methyl-n-(6-morpholin-4-o-tolyl-pyridin-3-yl)-isobutyramide.

Country Status (49)

Country Link
EP (1) EP1103545B1 (da)
JP (1) JP3480835B2 (da)
KR (1) KR100390117B1 (da)
CN (1) CN1152016C (da)
AR (1) AR033659A1 (da)
AT (1) ATE253561T1 (da)
AU (1) AU775292B2 (da)
BG (1) BG64622B1 (da)
BR (1) BRPI0005616B8 (da)
CA (1) CA2326529C (da)
CO (1) CO5251405A1 (da)
CZ (1) CZ299286B6 (da)
DE (2) DE60006340T2 (da)
DK (1) DK1103545T3 (da)
DO (1) DOP2000000106A (da)
EA (1) EA004404B1 (da)
ES (2) ES2208205T3 (da)
FR (1) FR2801590A1 (da)
GB (1) GB2356863A (da)
GC (1) GC0000151A (da)
GE (1) GEP20022763B (da)
GT (1) GT200000197A (da)
HR (1) HRP20000809A2 (da)
HU (1) HU224703B1 (da)
ID (1) ID28483A (da)
IL (1) IL139868A (da)
IS (1) IS2212B (da)
IT (1) IT1320120B1 (da)
JO (1) JO2298B1 (da)
MA (1) MA26754A1 (da)
MX (1) MXPA00011672A (da)
MY (1) MY127426A (da)
NO (1) NO317264B1 (da)
NZ (1) NZ508386A (da)
OA (1) OA11513A (da)
PA (1) PA8507201A1 (da)
PE (1) PE20010901A1 (da)
PL (1) PL195957B1 (da)
PT (1) PT1103545E (da)
SG (1) SG97171A1 (da)
SI (1) SI1103545T1 (da)
SK (1) SK285373B6 (da)
SV (1) SV2002000227A (da)
TN (1) TNSN00226A1 (da)
TR (1) TR200302077T4 (da)
UA (1) UA70326C2 (da)
UY (1) UY26458A1 (da)
YU (1) YU73400A (da)
ZA (1) ZA200006964B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL350427A1 (en) 1999-02-24 2002-12-16 Hoffmann La Roche Phenyl− and pyridinyl derivatives as neurokinin 1 antagonists
DE60014216T2 (de) * 1999-02-24 2006-03-02 F. Hoffmann-La Roche Ag 4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten
MXPA03000366A (es) * 2000-07-14 2003-05-27 Hoffmann La Roche N-oxidos como profarmacos antagonistas del receptor nk1 de derivados de 4-fenil-piridina.
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
JP2005515788A (ja) * 2002-01-31 2005-06-02 エフ．ホフマン−ラ　ロシュ　アーゲー プレプロタキキニン遺伝子における遺伝子多型
EP1643998B1 (en) 2003-07-03 2007-08-29 F. Hoffmann-La Roche Ag Dual nk1/nk3 antagonists for treating schizophrenia
US7288658B2 (en) 2003-07-15 2007-10-30 Hoffmann-La Roche Inc. Process for preparation of pyridine derivatives
ATE500224T1 (de) 2004-07-06 2011-03-15 Hoffmann La Roche Herstellungsverfahren für carboxamid-pyridin- derivate als zwischenprodukte bei der synthese von nk-1-rezeptor-antagonisten
UA90708C2 (ru) 2005-02-25 2010-05-25 Ф. Хоффманн-Ля Рош Аг Таблетки с улучшенной дисперсностью лекарственного вещества
JP4768010B2 (ja) * 2005-03-23 2011-09-07 エフ．ホフマン−ラ ロシュ アーゲー 嘔吐のためのｎｋ−１アンタゴニストの代謝物
NZ566419A (en) 2005-09-23 2010-03-26 Hoffmann La Roche Novel dosage formulation
EP2117538A1 (en) 2007-01-24 2009-11-18 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
US8426450B1 (en) 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
ES2993155T3 (en) 2013-03-15 2024-12-23 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
JP5806420B1 (ja) 2013-11-08 2015-11-10 キッセイ薬品工業株式会社 カルボキシメチルピペリジン誘導体
PL3102208T5 (pl) 2014-02-07 2024-10-14 Global Blood Therapeutics, Inc. Krystaliczny polimorf wolnej zasady 2-hydroksy-6-((2-(1-izopropylo-1h-pirazol-5-ilo)pirydyn-3-ylo)metoksy)benzaldehydu
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
KR101948238B1 (ko) 2016-08-19 2019-02-14 (주)케어젠 미녹시딜과 펩타이드의 결합체
KR102328682B1 (ko) 2018-08-27 2021-11-18 주식회사 대웅제약 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT533280E (pt) * 1991-09-20 2001-01-31 Glaxo Group Ltd Novas utilizacoes medicas para antagonistas de taquiquinina
CA2099233A1 (en) * 1992-06-29 1993-12-30 Conrad P. Dorn Morpholine and thiomorpholine tachykinin receptor antagonists
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
ES2164758T3 (es) * 1993-12-29 2002-03-01 Merck Sharp & Dohme Derivados de morfolina sustituidos y su uso como agentes terapeuticos.
TW385308B (en) * 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
EP0733632B1 (en) * 1995-03-24 2003-06-04 Takeda Chemical Industries, Ltd. Cyclic compounds, their production and use as tachykinin receptor antagonists
US5972938A (en) * 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
DE60014216T2 (de) * 1999-02-24 2006-03-02 F. Hoffmann-La Roche Ag 4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten
US6303790B1 (en) * 1999-11-29 2001-10-16 Hoffman-La Roche Inc. Process for the preparation of pyridine derivatives
MXPA03000366A (es) * 2000-07-14 2003-05-27 Hoffmann La Roche N-oxidos como profarmacos antagonistas del receptor nk1 de derivados de 4-fenil-piridina.
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives

Also Published As

Publication number Publication date
TR200302077T4 (tr) 2004-01-21
DE60006340T2 (de) 2004-09-09
GB2356863A (en) 2001-06-06
UY26458A1 (es) 2001-05-31
DE60006340D1 (de) 2003-12-11
BR0005616A (pt) 2001-07-17
KR100390117B1 (ko) 2003-07-04
DK1103545T3 (da) 2004-03-15
BG64622B1 (bg) 2005-09-30
MXPA00011672A (es) 2002-08-20
PL344147A1 (en) 2001-06-04
GT200000197A (es) 2002-05-22
ID28483A (id) 2001-05-31
ITMI20002575A1 (it) 2002-05-29
YU73400A (sh) 2003-02-28
DE10058310A1 (de) 2001-05-31
AU7178700A (en) 2001-05-31
SG97171A1 (en) 2003-07-18
CO5251405A1 (es) 2003-02-28
MY127426A (en) 2006-11-30
OA11513A (fr) 2004-02-03
HU0004725D0 (da) 2001-02-28
EP1103545A1 (en) 2001-05-30
JO2298B1 (en) 2005-09-12
EA200001114A2 (ru) 2001-08-27
SK17932000A3 (sk) 2001-11-06
ES2171134A1 (es) 2002-08-16
AU775292B2 (en) 2004-07-29
CZ20004399A3 (cs) 2001-07-11
PT1103545E (pt) 2004-03-31
MA26754A1 (fr) 2004-12-20
AR033659A1 (es) 2004-01-07
GEP20022763B (en) 2002-08-26
JP2001151754A (ja) 2001-06-05
EP1103545B1 (en) 2003-11-05
PL195957B1 (pl) 2007-11-30
IS2212B (is) 2007-02-15
FR2801590A1 (fr) 2001-06-01
HU224703B1 (en) 2006-01-30
NZ508386A (en) 2003-02-28
HUP0004725A2 (hu) 2002-04-29
DOP2000000106A (es) 2002-07-30
CZ299286B6 (cs) 2008-06-04
ZA200006964B (en) 2001-06-05
NO20006012D0 (no) 2000-11-28
ES2208205T3 (es) 2004-06-16
EA004404B1 (ru) 2004-04-29
BG104992A (en) 2001-11-30
IS5725A (is) 2001-05-29
CA2326529A1 (en) 2001-05-29
CA2326529C (en) 2009-12-22
ATE253561T1 (de) 2003-11-15
UA70326C2 (en) 2004-10-15
EA200001114A3 (ru) 2001-12-24
PE20010901A1 (es) 2001-09-20
NO20006012L (no) 2001-05-30
SV2002000227A (es) 2002-02-05
PA8507201A1 (es) 2002-02-21
IT1320120B1 (it) 2003-11-18
HRP20000809A2 (en) 2001-12-31
HK1036759A1 (en) 2002-01-18
CN1297888A (zh) 2001-06-06
BRPI0005616B8 (pt) 2021-07-06
SK285373B6 (sk) 2006-12-07
TNSN00226A1 (fr) 2002-05-30
SI1103545T1 (en) 2004-02-29
CN1152016C (zh) 2004-06-02
NO317264B1 (no) 2004-09-27
IL139868A (en) 2009-09-01
JP3480835B2 (ja) 2003-12-22
KR20010051983A (ko) 2001-06-25
BRPI0005616B1 (pt) 2017-12-12
GB0028566D0 (en) 2001-01-10
IL139868A0 (en) 2002-02-10

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