GB8726950D0 - Chemical process - Google Patents

Chemical process

Info

Publication number
GB8726950D0
GB8726950D0 GB878726950A GB8726950A GB8726950D0 GB 8726950 D0 GB8726950 D0 GB 8726950D0 GB 878726950 A GB878726950 A GB 878726950A GB 8726950 A GB8726950 A GB 8726950A GB 8726950 D0 GB8726950 D0 GB 8726950D0
Authority
GB
United Kingdom
Prior art keywords
formula
compounds
chemical process
cyclisation
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB878726950A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Co PLC
Original Assignee
Boots Co PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co PLC filed Critical Boots Co PLC
Priority to GB878726950A priority Critical patent/GB8726950D0/en
Publication of GB8726950D0 publication Critical patent/GB8726950D0/en
Priority to ZA888241A priority patent/ZA888241B/xx
Priority to ES198888310463T priority patent/ES2038310T3/es
Priority to DE8888310463T priority patent/DE3866086D1/de
Priority to AU26163/88A priority patent/AU628305B2/en
Priority to PCT/GB1988/000952 priority patent/WO1989004827A1/en
Priority to US07/378,216 priority patent/US5011931A/en
Priority to KR1019890701326A priority patent/KR890701563A/ko
Priority to JP63508842A priority patent/JPH02502013A/ja
Priority to HU886294A priority patent/HU204511B/hu
Priority to EP88909581A priority patent/EP0343206A1/en
Priority to AT88310463T priority patent/ATE69221T1/de
Priority to EP88310463A priority patent/EP0317149B1/en
Priority to RO140740A priority patent/RO104615B1/ro
Priority to IE883366A priority patent/IE883366L/xx
Priority to PH37784A priority patent/PH27439A/en
Priority to IL88358A priority patent/IL88358A/xx
Priority to MX013748A priority patent/MX168918B/es
Priority to TW077107879A priority patent/TW204344B/zh
Priority to YU209788A priority patent/YU46989B/sh
Priority to CS748988A priority patent/CS274487B2/cs
Priority to DD88321853A priority patent/DD290188A5/de
Priority to PT89024A priority patent/PT89024B/pt
Priority to NZ227008A priority patent/NZ227008A/en
Priority to PL1988275880A priority patent/PL157191B1/pl
Priority to CS236489A priority patent/CS274499B2/cs
Priority to SU894614311A priority patent/SU1766255A3/ru
Priority to DK347589A priority patent/DK347589D0/da
Priority to FI893405A priority patent/FI91063C/fi
Priority to BG089219A priority patent/BG50157A3/xx
Priority to NO89892935A priority patent/NO892935L/no
Priority to US07/663,085 priority patent/US5079264A/en
Priority to GR91402063T priority patent/GR3003378T3/el
Priority to LTRP1011A priority patent/LT2519B/xx
Priority to LV931270A priority patent/LV5671A3/xx
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
GB878726950A 1987-11-18 1987-11-18 Chemical process Pending GB8726950D0 (en)

Priority Applications (35)

Application Number Priority Date Filing Date Title
GB878726950A GB8726950D0 (en) 1987-11-18 1987-11-18 Chemical process
ZA888241A ZA888241B (en) 1987-11-18 1988-11-03 Process for the synthesis of 3-thio-4-quinolene derivatives and intermediate compounds for use therein,and their use as medicaments
RO140740A RO104615B1 (en) 1987-11-18 1988-11-07 Preparation method of 7-fluor-1-methyl-3-methylsulphonyl -4-quinoline
US07/378,216 US5011931A (en) 1987-11-18 1988-11-07 Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the sulfinyl, and sulfonyl analogs thereof
HU886294A HU204511B (en) 1987-11-18 1988-11-07 Process for producing quinolone derivatives
AU26163/88A AU628305B2 (en) 1987-11-18 1988-11-07 Process for the synthesis of 2 methyl sulphinyl-acetyl formanilide derivatives and their use as medicaments
PCT/GB1988/000952 WO1989004827A1 (en) 1987-11-18 1988-11-07 Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments
ES198888310463T ES2038310T3 (es) 1987-11-18 1988-11-07 Procedimiento para la sintesis de derivados de 3-tio-4-quinolona y sus compuestos intermedios.
KR1019890701326A KR890701563A (ko) 1987-11-18 1988-11-07 화학적 방법
JP63508842A JPH02502013A (ja) 1987-11-18 1988-11-07 化学方法
DE8888310463T DE3866086D1 (de) 1987-11-18 1988-11-07 Verfahren zur synthese von 3-thia-4-chinolonderivaten und zwischenprodukte dafuer und ihre verwendung als arzneimittel.
EP88909581A EP0343206A1 (en) 1987-11-18 1988-11-07 Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments
AT88310463T ATE69221T1 (de) 1987-11-18 1988-11-07 Verfahren zur synthese von 3-thia-4chinolonderivaten und zwischenprodukte dafuer und ihre verwendung als arzneimittel.
EP88310463A EP0317149B1 (en) 1987-11-18 1988-11-07 Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments
PH37784A PH27439A (en) 1987-11-18 1988-11-09 Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the sulfinyl and sulfonyl analogs thereof
IE883366A IE883366L (en) 1987-11-18 1988-11-09 Chemical process
MX013748A MX168918B (es) 1987-11-18 1988-11-10 Proceso para preparar compuestos de quinolona
IL88358A IL88358A (en) 1987-11-18 1988-11-10 Formanilide derivatives, process for their preparation and their use as active ingredients in cardiovascular compositions and as starting materials for the preparation of quinolone derivatives
YU209788A YU46989B (sh) 1987-11-18 1988-11-11 Postupak za dobijanje hinolonskih jedinjenja
TW077107879A TW204344B (enExample) 1987-11-18 1988-11-11
CS748988A CS274487B2 (en) 1987-11-18 1988-11-15 Method of quinolone derivatives production
DD88321853A DD290188A5 (de) 1987-11-18 1988-11-16 Chemische prozesse
PT89024A PT89024B (pt) 1987-11-18 1988-11-17 Processo de preparacao de derivados da quinolona
NZ227008A NZ227008A (en) 1987-11-18 1988-11-18 Preparation of 3-thio-4-quinolone derivatives; intermediate formanilide derivatives and pharmaceutical compositions containing the formanilide derivatives
PL1988275880A PL157191B1 (pl) 1987-11-18 1988-11-18 Sposób wytwarzania pochodnych chinolonu PL PL
CS236489A CS274499B2 (en) 1987-11-18 1989-04-17 Method of 7-fluor-1-methyl-3-methylthio-4-quinolone production
SU894614311A SU1766255A3 (ru) 1987-11-18 1989-05-17 Способ получени хинолонового производного
FI893405A FI91063C (fi) 1987-11-18 1989-07-13 Menetelmä kinoloniyhdisteiden valmistamiseksi
DK347589A DK347589D0 (da) 1987-11-18 1989-07-13 Fremgangsmaade til fremstilling af quinolonforbindelser
BG089219A BG50157A3 (bg) 1987-11-18 1989-07-17 Метод за получаване на производни на хинолина
NO89892935A NO892935L (no) 1987-11-18 1989-07-17 Fremgangsmaate for fremstilling av kinolinforbindelser.
US07/663,085 US5079264A (en) 1987-11-18 1991-03-01 Chemical process
GR91402063T GR3003378T3 (en) 1987-11-18 1991-12-18 Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments
LTRP1011A LT2519B (lt) 1987-11-18 1993-09-20 Chinoloninio darino gavimo budas
LV931270A LV5671A3 (lv) 1987-11-18 1993-11-25 Hinolona atvasinajumu iegusanas panemiens

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878726950A GB8726950D0 (en) 1987-11-18 1987-11-18 Chemical process

Publications (1)

Publication Number Publication Date
GB8726950D0 true GB8726950D0 (en) 1987-12-23

Family

ID=10627131

Family Applications (1)

Application Number Title Priority Date Filing Date
GB878726950A Pending GB8726950D0 (en) 1987-11-18 1987-11-18 Chemical process

Country Status (28)

Country Link
US (2) US5011931A (enExample)
EP (2) EP0317149B1 (enExample)
JP (1) JPH02502013A (enExample)
KR (1) KR890701563A (enExample)
AT (1) ATE69221T1 (enExample)
AU (1) AU628305B2 (enExample)
BG (1) BG50157A3 (enExample)
CS (1) CS274487B2 (enExample)
DD (1) DD290188A5 (enExample)
DE (1) DE3866086D1 (enExample)
ES (1) ES2038310T3 (enExample)
FI (1) FI91063C (enExample)
GB (1) GB8726950D0 (enExample)
GR (1) GR3003378T3 (enExample)
HU (1) HU204511B (enExample)
IE (1) IE883366L (enExample)
IL (1) IL88358A (enExample)
MX (1) MX168918B (enExample)
NZ (1) NZ227008A (enExample)
PH (1) PH27439A (enExample)
PL (1) PL157191B1 (enExample)
PT (1) PT89024B (enExample)
RO (1) RO104615B1 (enExample)
SU (1) SU1766255A3 (enExample)
TW (1) TW204344B (enExample)
WO (1) WO1989004827A1 (enExample)
YU (1) YU46989B (enExample)
ZA (1) ZA888241B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
US6110489A (en) * 1998-05-01 2000-08-29 Cutler; Neal R. Use of quinolines and quinolones to treat male erectile dysfunction
US6194433B1 (en) 1998-10-05 2001-02-27 Neal R. Cutler Sexual dysfunction in females
US6132753A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6426084B1 (en) * 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6132757A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6303135B1 (en) 1999-07-08 2001-10-16 Neal R. Cutler Use of quinolines and quinolones to treat male erectile dysfunction
US6307050B1 (en) * 2000-08-29 2001-10-23 R. T. Alamo Venture I Llc Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6562838B2 (en) 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6531603B1 (en) 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en) 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6660864B2 (en) 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
US6649764B2 (en) * 2001-10-25 2003-11-18 R. T. Alamo Ventures I, Llc Stereospecific enrichment of heterocyclic enantiomers
US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US6730790B2 (en) * 2002-03-01 2004-05-04 R.T. Alamo Ventures I. Llc Chlorinated heterocyclic compounds and methods of synthesis
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920699A (en) * 1974-04-26 1975-11-18 Warner Lambert Co Process for the cyclization of aryl(methylsulfinyl)-methyl ketones and compounds produced thereby
US4192873A (en) * 1976-11-25 1980-03-11 Ciba-Geigy Corporation Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones
NZ193167A (en) * 1979-03-27 1984-08-24 Boots Co Plc Quinoline derivatives and pharmaceutical compositions
IE51542B1 (en) * 1980-09-26 1987-01-07 Boots Co Ltd Therapeutic agents
FR2532939A1 (fr) * 1982-09-13 1984-03-16 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus
US4552884A (en) * 1984-01-13 1985-11-12 The Boots Company Plc Method of treating heart disease
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
GB8515209D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8627698D0 (en) * 1986-11-20 1986-12-17 Boots Co Plc Therapeutic agents
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process

Also Published As

Publication number Publication date
FI91063B (fi) 1994-01-31
YU209788A (en) 1990-08-31
CS274487B2 (en) 1991-04-11
PL275880A1 (en) 1989-06-12
JPH02502013A (ja) 1990-07-05
KR890701563A (ko) 1989-12-21
RO104615B1 (en) 1992-11-03
AU2616388A (en) 1989-06-14
ATE69221T1 (de) 1991-11-15
MX168918B (es) 1993-06-14
SU1766255A3 (ru) 1992-09-30
HU204511B (en) 1992-01-28
GR3003378T3 (en) 1993-02-17
WO1989004827A1 (en) 1989-06-01
PL157191B1 (pl) 1992-05-29
EP0317149B1 (en) 1991-11-06
EP0343206A1 (en) 1989-11-29
PT89024A (pt) 1988-12-01
YU46989B (sh) 1994-09-09
CS748988A2 (en) 1990-09-12
FI893405A0 (fi) 1989-07-13
FI893405L (fi) 1989-07-13
HUT53085A (en) 1990-09-28
TW204344B (enExample) 1993-04-21
DD290188A5 (de) 1991-05-23
EP0317149A1 (en) 1989-05-24
BG50157A3 (bg) 1992-05-15
DE3866086D1 (de) 1991-12-12
ZA888241B (en) 1989-10-25
IL88358A (en) 1993-02-21
ES2038310T3 (es) 1993-07-16
US5011931A (en) 1991-04-30
NZ227008A (en) 1991-10-25
PT89024B (pt) 1993-02-26
IL88358A0 (en) 1989-06-30
PH27439A (en) 1993-07-02
FI91063C (fi) 1994-05-10
US5079264A (en) 1992-01-07
AU628305B2 (en) 1992-09-17
IE883366L (en) 1989-05-18

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