KR890701563A - 화학적 방법 - Google Patents

화학적 방법

Info

Publication number
KR890701563A
KR890701563A KR1019890701326A KR890701326A KR890701563A KR 890701563 A KR890701563 A KR 890701563A KR 1019890701326 A KR1019890701326 A KR 1019890701326A KR 890701326 A KR890701326 A KR 890701326A KR 890701563 A KR890701563 A KR 890701563A
Authority
KR
South Korea
Prior art keywords
compound
formula
xii
methyl
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019890701326A
Other languages
English (en)
Korean (ko)
Inventor
매클린 라클란
로이드 로버츠 데이빗
바론 케네스
존 니콜 케네스
어네스트 해리슨 알베르트
Original Assignee
디 앤 에드먼드숀
더 부츠 캄파니 피엘시
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 디 앤 에드먼드숀, 더 부츠 캄파니 피엘시 filed Critical 디 앤 에드먼드숀
Publication of KR890701563A publication Critical patent/KR890701563A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1019890701326A 1987-11-18 1988-11-07 화학적 방법 Ceased KR890701563A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878726950A GB8726950D0 (en) 1987-11-18 1987-11-18 Chemical process
GB?8726950? 1987-11-18
PCT/GB1988/000952 WO1989004827A1 (en) 1987-11-18 1988-11-07 Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments

Publications (1)

Publication Number Publication Date
KR890701563A true KR890701563A (ko) 1989-12-21

Family

ID=10627131

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890701326A Ceased KR890701563A (ko) 1987-11-18 1988-11-07 화학적 방법

Country Status (28)

Country Link
US (2) US5011931A (enExample)
EP (2) EP0317149B1 (enExample)
JP (1) JPH02502013A (enExample)
KR (1) KR890701563A (enExample)
AT (1) ATE69221T1 (enExample)
AU (1) AU628305B2 (enExample)
BG (1) BG50157A3 (enExample)
CS (1) CS274487B2 (enExample)
DD (1) DD290188A5 (enExample)
DE (1) DE3866086D1 (enExample)
ES (1) ES2038310T3 (enExample)
FI (1) FI91063C (enExample)
GB (1) GB8726950D0 (enExample)
GR (1) GR3003378T3 (enExample)
HU (1) HU204511B (enExample)
IE (1) IE883366L (enExample)
IL (1) IL88358A (enExample)
MX (1) MX168918B (enExample)
NZ (1) NZ227008A (enExample)
PH (1) PH27439A (enExample)
PL (1) PL157191B1 (enExample)
PT (1) PT89024B (enExample)
RO (1) RO104615B1 (enExample)
SU (1) SU1766255A3 (enExample)
TW (1) TW204344B (enExample)
WO (1) WO1989004827A1 (enExample)
YU (1) YU46989B (enExample)
ZA (1) ZA888241B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
US6110489A (en) * 1998-05-01 2000-08-29 Cutler; Neal R. Use of quinolines and quinolones to treat male erectile dysfunction
US6194433B1 (en) 1998-10-05 2001-02-27 Neal R. Cutler Sexual dysfunction in females
US6132753A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6426084B1 (en) * 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6132757A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6303135B1 (en) 1999-07-08 2001-10-16 Neal R. Cutler Use of quinolines and quinolones to treat male erectile dysfunction
US6307050B1 (en) * 2000-08-29 2001-10-23 R. T. Alamo Venture I Llc Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6562838B2 (en) 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6531603B1 (en) 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en) 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6660864B2 (en) 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
US6649764B2 (en) * 2001-10-25 2003-11-18 R. T. Alamo Ventures I, Llc Stereospecific enrichment of heterocyclic enantiomers
US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US6730790B2 (en) * 2002-03-01 2004-05-04 R.T. Alamo Ventures I. Llc Chlorinated heterocyclic compounds and methods of synthesis
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920699A (en) * 1974-04-26 1975-11-18 Warner Lambert Co Process for the cyclization of aryl(methylsulfinyl)-methyl ketones and compounds produced thereby
US4192873A (en) * 1976-11-25 1980-03-11 Ciba-Geigy Corporation Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones
NZ193167A (en) * 1979-03-27 1984-08-24 Boots Co Plc Quinoline derivatives and pharmaceutical compositions
IE51542B1 (en) * 1980-09-26 1987-01-07 Boots Co Ltd Therapeutic agents
FR2532939A1 (fr) * 1982-09-13 1984-03-16 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus
US4552884A (en) * 1984-01-13 1985-11-12 The Boots Company Plc Method of treating heart disease
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
GB8515209D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8627698D0 (en) * 1986-11-20 1986-12-17 Boots Co Plc Therapeutic agents
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process

Also Published As

Publication number Publication date
FI91063B (fi) 1994-01-31
YU209788A (en) 1990-08-31
CS274487B2 (en) 1991-04-11
PL275880A1 (en) 1989-06-12
JPH02502013A (ja) 1990-07-05
RO104615B1 (en) 1992-11-03
AU2616388A (en) 1989-06-14
ATE69221T1 (de) 1991-11-15
MX168918B (es) 1993-06-14
SU1766255A3 (ru) 1992-09-30
HU204511B (en) 1992-01-28
GR3003378T3 (en) 1993-02-17
WO1989004827A1 (en) 1989-06-01
PL157191B1 (pl) 1992-05-29
EP0317149B1 (en) 1991-11-06
EP0343206A1 (en) 1989-11-29
PT89024A (pt) 1988-12-01
GB8726950D0 (en) 1987-12-23
YU46989B (sh) 1994-09-09
CS748988A2 (en) 1990-09-12
FI893405A0 (fi) 1989-07-13
FI893405L (fi) 1989-07-13
HUT53085A (en) 1990-09-28
TW204344B (enExample) 1993-04-21
DD290188A5 (de) 1991-05-23
EP0317149A1 (en) 1989-05-24
BG50157A3 (bg) 1992-05-15
DE3866086D1 (de) 1991-12-12
ZA888241B (en) 1989-10-25
IL88358A (en) 1993-02-21
ES2038310T3 (es) 1993-07-16
US5011931A (en) 1991-04-30
NZ227008A (en) 1991-10-25
PT89024B (pt) 1993-02-26
IL88358A0 (en) 1989-06-30
PH27439A (en) 1993-07-02
FI91063C (fi) 1994-05-10
US5079264A (en) 1992-01-07
AU628305B2 (en) 1992-09-17
IE883366L (en) 1989-05-18

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19890714

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19931105

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19890714

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19970428

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19970711

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19970428

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I