GB861470A - Improvements in or relating to the manufacture of steroids - Google Patents
Improvements in or relating to the manufacture of steroidsInfo
- Publication number
- GB861470A GB861470A GB861470DA GB861470A GB 861470 A GB861470 A GB 861470A GB 861470D A GB861470D A GB 861470DA GB 861470 A GB861470 A GB 861470A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- dione
- dihydroxy
- prepared
- pregnadiene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Steroid Compounds (AREA)
Abstract
11a -Hydroxy-steriods are prepared by contacting an 11-methylene steroid with aerobically growing fungus of the genus Sporotrichum. In the case of steroids of the pregnane series, degradation of the side chain also takes place at an aeration rate of 5 to 15 litres of air per minute per 100 litres of medium to form an 11a , 17b -dihydroxy-androstane. Thus the process may be applied to an 11-oxygenated pregnane so that only degradation takes place in the side chain to form an 11-oxygenated-17b -hydroxy-androstane. The fungus may be of the species sulphurescens, carnis, epigaeum, bombycinum, foliicola Oud., pulviniforme Thum, olivaceum Fr, globuliferum, maritumum, orthophilum, griseolum, roseolum Oud. et Beijerinck, poae PK, equi, Beurmanni M. et Ram., and Schencckii. In the examples 11a ,17b -dihydroxy-17a -methyl - 1,4 - androstadien - 3 - one is prepared from 1 - dehydromethyltestosterone, 11a ,17b -dihydroxy - 1,4 - androstadien - 3 - one is prepared from 1-dehydrotestosterone, 21-hydroxy-1,4 - pregnadiene - 3,20 - dione, 1,4 - pregnadiene - 3,20 - dione, 17a ,21 - dihydroxy - 1,4-pregnadiene - 3,20 - dione, 17b - hydroxy - 1,4-androstadiene - 3 - one and 11a - hydroxy - 1,4-pregnadiene - 3,20 - dione, is subsequently acetylated to form the corresponding 11a ,17b -diacetoxy compound, 11a -hydroxy-1,4-androstadiene - 3,17 - dione is prepared from 1,4-androstadiene - 3,17 - dione and is subsequently acetylated to form the corresponding 11a - acetoxy compound, 11a - hydroxy - testosterone is prepared from progesterone, desoxycorticosterone, 17a ,21 - dihydroxy - 4 - pregnene - 3,20 - dione, 17a - hydroxy - progesterone, 11a - hydroxy - progesterone, 11a ,21 - dihydroxy - 4 - pregnene - 3,20 - dione and testosterone; 11a -hydroxy-progesterone is prepared from progesterone; and 11a ,21 - dihydroxy-1,4 - pregnadiene - 3,20 - dione is prepared from 21 - hydroxy - 1,4 - pregnadiene - 3,20 - dione. Specifications 724,094 and 767,422 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US861470XA | 1956-08-21 | 1956-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB861470A true GB861470A (en) | 1961-02-22 |
Family
ID=22196577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB861470D Expired GB861470A (en) | 1956-08-21 | 1957-07-15 | Improvements in or relating to the manufacture of steroids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB861470A (en) |
-
1957
- 1957-07-15 GB GB861470D patent/GB861470A/en not_active Expired
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