GB789363A - Steroids and the preparation thereof - Google Patents
Steroids and the preparation thereofInfo
- Publication number
- GB789363A GB789363A GB15537/56A GB1553756A GB789363A GB 789363 A GB789363 A GB 789363A GB 15537/56 A GB15537/56 A GB 15537/56A GB 1553756 A GB1553756 A GB 1553756A GB 789363 A GB789363 A GB 789363A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- steroid
- nocardia
- pregnene
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
3 - Keto - D 1,4 - steroids are obtained by contacting a D 4-steroid having from 18 to 21 atoms in the carbon skeleton with the dehydrogenating activity of an organism of the genus Nocardia, e.g. N. coeliaca, N. convoluta, N. corallina, N. crythropolis, N. gardneri, N. minima, N. polychromogenes, N. opaca and N. globerula. The process may be effected by bringing the steroid in aqueous solution or suspension into contact either with an actively growing culture of Nocardia, with cells of Nocardia removed from the growing culture and suspended in a suitable medium, or by contacting the steroid with extracts of dehydrogenating enzymes obtained from a culture of a species of the genus Nocardia. Preferably the steroid is subjected to submerged aerated fermentation with a living culture of the organism. As starting materials there may be used hydrocortisone, cortisone, corticosterone, Compound S, 14a -hydroxy Compound S, desoxycorticosterone, androstenedione, nortestosterone, 17a - hydroxyprogesterone, 1 - ketoprogesterone, 9a - fluoro - Compound F, 14a -hydroxy-Compound F, 11-epihydrocortisone, D 4,6 - androstadiendione, 11b ,17a - dihydroxyprogesterone, D 14 - dehydro Compound S, testosterone, progesterone, 16 - dehydroprogesterone, D 9(11) - dehydro-Compound S, D 4 - pregnene - 17a ,21 - diol-3,20 - dione, D 4 - pregnene - 11b ,14a ,17a ,21-tetrol - 3,20 - dione and D 4 - pregnene - 14a , 17a ,21 - triol - 3,11,20 - trione. Examples describe fermentations utilizing N. opaca and N. globerula.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US789363XA | 1955-10-04 | 1955-10-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB789363A true GB789363A (en) | 1958-01-22 |
Family
ID=22147121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB15537/56A Expired GB789363A (en) | 1955-10-04 | 1956-05-18 | Steroids and the preparation thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB789363A (en) |
-
1956
- 1956-05-18 GB GB15537/56A patent/GB789363A/en not_active Expired
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