GB767422A - Process for the production of 17-ketosteroids - Google Patents

Process for the production of 17-ketosteroids

Info

Publication number
GB767422A
GB767422A GB27991/54A GB2799154A GB767422A GB 767422 A GB767422 A GB 767422A GB 27991/54 A GB27991/54 A GB 27991/54A GB 2799154 A GB2799154 A GB 2799154A GB 767422 A GB767422 A GB 767422A
Authority
GB
United Kingdom
Prior art keywords
dione
hydroxy
androstene
trione
species
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB27991/54A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB767422A publication Critical patent/GB767422A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)

Abstract

17-Ketosteroids are produced by bringing into contact a fungus of the genus Gliocladium, or steroid fermentation enzymes derived therefrom, with a 20-oxygenated steroid under aerobic conditions. The process may be carried out by growing the fungus under aerobic conditions, preferably with agitation, in the presence of the 20-oxygenated steroid and of a nutrient medium preferably containing assimilable non-steroidal carbon (e.g. carbohydrate), assimilable nitrogen and phosphorus, and, if desired, other additions such as magnesium sulphate. Preferred fungi are those of the species G. catenulatum, G. roseum, G. deliquescens, and G. luteolum. Examples describe the use of these species in the production of: (1) 4-androstene-3 : 17-dione and its 6b -hydroxy derivative from progesterone, and (2)-(5) from 11-desoxycorticosterone and its acetate or other esters; (6) adrenosterone from 11-ketoprogesterone; (7) 4-androstene-3 : 17-dione from 21-methylprogesterone; (8) 3-hydroxyandrostan - 17 - one from 3b : 17a : 20-allopregnanetriol; (9) 3b - hydroxy - 5 - androsten - 17 - one; (10) etiocholane - 3 : 16 : 17 - trione from pregnane-3 : 6 : 20-trione; (11) 6b -hydroxy - 4 - androstene - 3 : 17 - dione from 6b - hydroxyprogesterone; (12) etiocholane - 3 : 17-dione from pregnane-3 : 20-dione; (13) androstane-3 : 11 : 17-trione from allopregnane-3 : 11 : 20-trione; (14) 4-androstene-3 : 17-dione and its 6b -hydroxy derivative from 17a : 21-dihydroxy - 4 - pregnene - 3 : 20 - dione; (15) adrenosterone from cortisone; and (16) from cortisone acetate; (17) 11a -hydroxy-4-androstene 3 : 17 - dione from 11a : 17a : 21 - trihydroxy - 4 - pregnene - 3 : 20 - dione; (18) 3b -hydroxy - 5 - androsten - 17 - one from 3b - hydroxy - 21 - ethyl - 5 - pregnen - 20 - one. Lists are given of additional starting materials and, in some cases, the products obtainable therefrom, and of other species of Gliocladium.
GB27991/54A 1953-10-01 1954-09-28 Process for the production of 17-ketosteroids Expired GB767422A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US767422XA 1953-10-01 1953-10-01

Publications (1)

Publication Number Publication Date
GB767422A true GB767422A (en) 1957-02-06

Family

ID=22133901

Family Applications (1)

Application Number Title Priority Date Filing Date
GB27991/54A Expired GB767422A (en) 1953-10-01 1954-09-28 Process for the production of 17-ketosteroids

Country Status (1)

Country Link
GB (1) GB767422A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814324A (en) * 1987-03-06 1989-03-21 Merck & Co., Inc. Sterol inhibitors of testosterone 5α-reductase

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814324A (en) * 1987-03-06 1989-03-21 Merck & Co., Inc. Sterol inhibitors of testosterone 5α-reductase

Similar Documents

Publication Publication Date Title
US2649402A (en) Steroids
US2902410A (en) Process for the 1,2-dehydrogenation of a steroid with septomyxa
US2695260A (en) Process for the oxygenation of steroids with the oxygenating activity of neurospora
US3530038A (en) Process for preparation of trihydroxy steroids
US3359287A (en) 16-methylene-17alpha-hydroxy progesterones and derivatives thereof
US2889255A (en) 15-hydroxylation of steroids by gibberella and fusarium
GB767422A (en) Process for the production of 17-ketosteroids
US3039926A (en) 19-hydroxy pregnenes
GB769226A (en) Process for the production of 17-ketosteroids
GB792803A (en) Oxidation products from compounds of the steroid series and process of making same
US2861088A (en) 11alpha, 17alpha, 21-trihydroxy-4-pregnene-3, 20-dione and esters thereof
US3203869A (en) 11alpha-hydroxylation of 6-substituted-11-desoxy steroids with microorganisms of thegenus fusarium, liseola section
US3056731A (en) Dehydrogenation of steroids by microorganisms of the genus mycococcus
GB829260A (en) Preparation of steroid compounds
GB846914A (en) Production of steroid compounds
GB824348A (en) Process for preparing steroid compounds
GB789363A (en) Steroids and the preparation thereof
US3149050A (en) Process for the production of 11alpha-hydroxylation steroids with panaeolus
US3098796A (en) 16-hydroxylation of steroids
GB770000A (en) Improvements in or relating to steroids
GB823719A (en) Process for splitting steroid racemates
GB769998A (en) Improvements in or relating to steroids
GB1184287A (en) A process for the manufacture of Steroids of the Androstane Series
GB839257A (en) Production of steroids
GB829903A (en) Steroids and the preparation thereof