GB770000A - Improvements in or relating to steroids - Google Patents

Improvements in or relating to steroids

Info

Publication number
GB770000A
GB770000A GB7798/56A GB779856A GB770000A GB 770000 A GB770000 A GB 770000A GB 7798/56 A GB7798/56 A GB 7798/56A GB 779856 A GB779856 A GB 779856A GB 770000 A GB770000 A GB 770000A
Authority
GB
United Kingdom
Prior art keywords
cyclopentanophenanthrene
dione
hydroxy
desoxycorticosterone
corticosterone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7798/56A
Inventor
Gilbert Malcolm Shull
Donald Albert Kita
Jacob White Davisson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Priority to GB7798/56A priority Critical patent/GB770000A/en
Priority to CH322066D priority patent/CH322066A/en
Publication of GB770000A publication Critical patent/GB770000A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Cyclopentanophenanthrene compounds having a methylene group in the nucleus at the 11-position, e.g. cortical steroid type compounds having a methylene group at the 11-position, are 11b -hydroxylated by the action of oxygenating substances produced by growing a microorganism of the species Curvularia lunata. The cyclopentanophenanthrene reactant may be subjected to the action of a growing culture of the micro-organism, or the micro-organism may be cultivated aerobically in a nutrient medium until substantial growth is obtained, the mycelium is separated from the broth and the cyclopentanophenanthrene reactant is then contacted with an aqueous suspension of the mycelium. Cyclopentanophenanthrene reactants may have a keto or hydroxy group at the 3-position, a 21-hydroxy group and carbon to carbon double bonds in the nucleus, e.g. at the 3,4- or 5,6-position. Specified reactants are progesterone, D 4 - pregnene - 17a - ol - 3,20-dione, testosterone, D 4 - androstene - 3,17-dione and D 1,4 - pregnadiene - 17a ,21 - diol-3,20-dione. In the examples compound F (17 - hydroxy - corticosterone) is prepared from compound S (17 - hydroxy - 11 - desoxycorticosterone), and corticosterone is prepared from 11-desoxycorticosterone; in each case an aqueous nutrient medium is used.
GB7798/56A 1953-04-21 1953-12-16 Improvements in or relating to steroids Expired GB770000A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB7798/56A GB770000A (en) 1953-04-21 1953-12-16 Improvements in or relating to steroids
CH322066D CH322066A (en) 1953-04-21 1954-01-16 Process for the preparation of 11B-hydroxy steroids

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US322066XA 1953-04-21 1953-04-21
US769998XA 1953-04-21 1953-04-21
US1164173XA 1953-04-21 1953-04-21
GB7798/56A GB770000A (en) 1953-04-21 1953-12-16 Improvements in or relating to steroids

Publications (1)

Publication Number Publication Date
GB770000A true GB770000A (en) 1957-03-13

Family

ID=34916411

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7798/56A Expired GB770000A (en) 1953-04-21 1953-12-16 Improvements in or relating to steroids

Country Status (2)

Country Link
CH (1) CH322066A (en)
GB (1) GB770000A (en)

Also Published As

Publication number Publication date
CH322066A (en) 1957-05-31

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