GB624696A - Improvements in or relating to method of preparing a stable aqueous theophylline solution and the product resulting therefrom - Google Patents

Improvements in or relating to method of preparing a stable aqueous theophylline solution and the product resulting therefrom

Info

Publication number
GB624696A
GB624696A GB10548/46A GB1054846A GB624696A GB 624696 A GB624696 A GB 624696A GB 10548/46 A GB10548/46 A GB 10548/46A GB 1054846 A GB1054846 A GB 1054846A GB 624696 A GB624696 A GB 624696A
Authority
GB
United Kingdom
Prior art keywords
theophylline
amino acid
alkali metal
aqueous
specified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB10548/46A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JOHN CHRISTIAN KRANTZ
Original Assignee
JOHN CHRISTIAN KRANTZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JOHN CHRISTIAN KRANTZ filed Critical JOHN CHRISTIAN KRANTZ
Publication of GB624696A publication Critical patent/GB624696A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Theophylline may be stabilized in aqueous solution by the interaction of theophylline, an amino acid and an alkali metal hydroxide. The theophylline may be dissolved in the aqueous alkali metal hydroxide and the amino acid added thereto, or alternatively, aqueous solutions of the alkali metal salts of theophylline or the amino acid may be used in conjunction with the appropriate free amino acid or theophylline as may be. Glycine, alanine, valine, leucine and glutamic acid are the specified amino acids and potassium and sodium the alkali metals.ALSO:Theophyllin compositions stable in aqueous solutions are prepared by mixing together in aqueous solution theophylline and an aliphatic amino acid under conditions such that one of the aforementioned substances is in the form of its alkali metal salt. The theophylline may be dissolved in aqueous alkali metal hydroxide and the amino acid added thereto, or, alternatively, aqueous solutions of alkali metal salts of theophylline or the amino acid may be used in conjunction with the appropriate free amino acid or theophylline, as may be. The aqueous solution so formed may be used as such or evaporated to dryness to form a solid composition. The composition may also include a basic aluminium salt of an amino acid. Glycine, alanine, valine, leucine and glutamic acid are specified amino acids, while potassium and sodium hydroxides are specified alkali metal hydroxides.
GB10548/46A 1945-09-06 1946-04-05 Improvements in or relating to method of preparing a stable aqueous theophylline solution and the product resulting therefrom Expired GB624696A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US624696XA 1945-09-06 1945-09-06

Publications (1)

Publication Number Publication Date
GB624696A true GB624696A (en) 1949-06-15

Family

ID=22042695

Family Applications (1)

Application Number Title Priority Date Filing Date
GB10548/46A Expired GB624696A (en) 1945-09-06 1946-04-05 Improvements in or relating to method of preparing a stable aqueous theophylline solution and the product resulting therefrom

Country Status (1)

Country Link
GB (1) GB624696A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507892A1 (en) * 1981-06-22 1982-12-24 Malesci Sas ANTIBRONCHOSPASTIC COMPOSITIONS CONTAINING THEOPHYLLINE SALT WITH AN AMINO ACID AND THEIR PREPARATION

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507892A1 (en) * 1981-06-22 1982-12-24 Malesci Sas ANTIBRONCHOSPASTIC COMPOSITIONS CONTAINING THEOPHYLLINE SALT WITH AN AMINO ACID AND THEIR PREPARATION

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