GB639854A - Improvements in or relating to the purification of pteridines - Google Patents
Improvements in or relating to the purification of pteridinesInfo
- Publication number
- GB639854A GB639854A GB13771/47A GB1377147A GB639854A GB 639854 A GB639854 A GB 639854A GB 13771/47 A GB13771/47 A GB 13771/47A GB 1377147 A GB1377147 A GB 1377147A GB 639854 A GB639854 A GB 639854A
- Authority
- GB
- United Kingdom
- Prior art keywords
- magnesium
- solution
- water
- magnesium salt
- pteridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Manufacture And Refinement Of Metals (AREA)
Abstract
A reaction mixture containing a pteridine of the formula< <FORM:0639854/IV (b)/1> wherein OH represents an amide group derived from the amino group of glutamic acid or more than one molecule of glutamic acid joined by peptide linkages, is treated with magnesium carbonate, oxide or hydroxide in the presence of water, and the aqueous solution containing the magnesium salt of the above pteridine is separated from the insoluble matter. A water-soluble compound of a metal other than magnesium may be first added to the reaction mixture in the presence of water, the aqueous solution of the metal salt is separated from the insoluble matter and is treated with a water-soluble magnesium compound to form the magnesium salt of the above pteridine by double decomposition. The solution of the magnesium salt may be a hot concentrated solution so that the magnesium salt precipitates out on cooling, e.g. in the case of folic acid itself, the temperature of the solution may be between 75 DEG and 100 DEG C. When the solution contains the magnesium salt of folic acid, the free acid may be precipitated by acidifying the solution to about pH 3. In the examples, magnesium folate is prepared from reaction mixtures containing pteridines, and is converted to folic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US639854XA | 1946-08-13 | 1946-08-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB639854A true GB639854A (en) | 1950-07-05 |
Family
ID=22052776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB13771/47A Expired GB639854A (en) | 1946-08-13 | 1947-05-22 | Improvements in or relating to the purification of pteridines |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB639854A (en) |
-
1947
- 1947-05-22 GB GB13771/47A patent/GB639854A/en not_active Expired
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