GB713853A - Purification of synthetic folic acid - Google Patents
Purification of synthetic folic acidInfo
- Publication number
- GB713853A GB713853A GB23488/51A GB2348851A GB713853A GB 713853 A GB713853 A GB 713853A GB 23488/51 A GB23488/51 A GB 23488/51A GB 2348851 A GB2348851 A GB 2348851A GB 713853 A GB713853 A GB 713853A
- Authority
- GB
- United Kingdom
- Prior art keywords
- folic acid
- solution
- hydroxide
- alkali
- ammonium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Synthetic folic acid is separated from impurities associated therewith by mixing crude folic acid with an aqueous solution of an alkali-metal hydroxide or ammonium hydroxide to form an aqueous alkaline solution of alkali-metal or ammonium folate having dissolved therein between about 3 and about 10 grams of folic acid per litre, mixing the alkali-metal or ammonium folate solution with a solid adsorbent consisting of calcium oxide, calcium hydroxide, calcium carbonate, magnesium oxide, magnesium hydroxide, magnesium carbonate, zinc oxide, zinc hydroxide, zinc carbonate or cadmium carbonate, or mixtures thereof, at room temperature to adsorb a substantial portion of the impurities present in the solution on the solid adsorbent while the alkali-metal or ammonium folate remains in solution, separating the solid adsorbent and impurities adsorbed thereon from the solution of the alkali-metal or ammonium folate, and precipitating purified folic acid from the thusclarified solution by acidification. It is preferable to use about three moles of sodium hydroxide per mole of folic acid and to employ finely-divided magnesium hydroxide as the adsorbent. The crude folic acid may contain about 65 to 85 per cent of folic acid itself. The aqueous solution may contain 8 grams of folic acid per litre. The quantity of adsorbent added may be varied over a wide range, a suitable figure being about one gram of adsorbent per gram of folic acid. The folic acid may be recovered from the purified alkaline solution by adjusting the pH to approximately 3, e.g. with hydrochloric acid, whereupon the folic acid precipitates. It is preferable to dilute the alkaline solution of purified folic acid to a concentration of about 3 grams of folic acid per litre, heat the solution to about 90 DEG to 95 DEG C. and then adjust the pH of the hot solution to approximately 3 with hydrochloric acid, the folic acid slowly precipitating on cooling. A number of detailed examples are given.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US713853XA | 1950-11-30 | 1950-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB713853A true GB713853A (en) | 1954-08-18 |
Family
ID=22100961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23488/51A Expired GB713853A (en) | 1950-11-30 | 1951-10-09 | Purification of synthetic folic acid |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB713853A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104098569A (en) * | 2014-08-02 | 2014-10-15 | 济南兆康医药科技有限公司 | Medicinal folic acid purifying method |
| CN109621860A (en) * | 2019-01-28 | 2019-04-16 | 河北冀衡（集团）药业有限公司 | A kind of synthetic method of agitating device, the reactor tank for synthesizing folic acid and folic acid |
| CN114671449A (en) * | 2022-04-26 | 2022-06-28 | 贺州学院 | Synthetic method of hollow calcium hydroxide microspheres |
-
1951
- 1951-10-09 GB GB23488/51A patent/GB713853A/en not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104098569A (en) * | 2014-08-02 | 2014-10-15 | 济南兆康医药科技有限公司 | Medicinal folic acid purifying method |
| CN104098569B (en) * | 2014-08-02 | 2016-05-11 | 济南康和医药科技有限公司 | A kind of purification process of medicinal folic acid |
| CN109621860A (en) * | 2019-01-28 | 2019-04-16 | 河北冀衡（集团）药业有限公司 | A kind of synthetic method of agitating device, the reactor tank for synthesizing folic acid and folic acid |
| CN109621860B (en) * | 2019-01-28 | 2024-04-12 | 河北冀衡药业股份有限公司 | Stirring device, reaction tank for synthesizing folic acid and folic acid synthesizing method |
| CN114671449A (en) * | 2022-04-26 | 2022-06-28 | 贺州学院 | Synthetic method of hollow calcium hydroxide microspheres |
| CN114671449B (en) * | 2022-04-26 | 2023-08-25 | 贺州学院 | Synthesis method of hollow calcium hydroxide microspheres |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS572656A (en) | Decoloration and purification of stevia extract | |
| KR930703229A (en) | Basic calcium aluminum hydroxide dacarboxylate, preparation method thereof and use thereof | |
| KR927003502A (en) | Basic calcium hydroxide aluminum hydroxide, manufacturing method and use thereof | |
| GB713853A (en) | Purification of synthetic folic acid | |
| GB1449704A (en) | Method for separate recovery of selenium and mercury from raw materials containing them | |
| GB962812A (en) | Process for the production of finely dispersed calcium carbonate | |
| US2662081A (en) | Purification of synthetic folic acid | |
| JPS5459237A (en) | Reduction of aromatic mitro compound | |
| GB644743A (en) | Improvements in or relating to the purification of selenium | |
| GB1094921A (en) | Improvements in or relating to the manufacture of lead 4:6 dinitroresorcinate | |
| ES253183A1 (en) | Magnesium glutamate hydrobromide and processes for the production thereof | |
| GB903345A (en) | Process for the manufacture of finely divided calcium carbonate | |
| GB639854A (en) | Improvements in or relating to the purification of pteridines | |
| GB932523A (en) | Process for the production of lead hydroxide oxide of the formula 5 pbo.2ho | |
| GB718020A (en) | Improvements in or relating to the recovery of the antibiotic oxytetracycline | |
| ES357600A1 (en) | Animal feeding containing pentacalcium orthoperiodate | |
| US2626947A (en) | Decolorization of synthetic folic acid | |
| GB492095A (en) | Improvements in or relating to insulin | |
| GB680662A (en) | Process for the recovery of pure folic acid | |
| GB765514A (en) | Process for the purification of diphenylol propane | |
| GB629479A (en) | Improvements in or relating to the production of antibiotic agents | |
| GB658766A (en) | Improvements in and relating to the purification of antibiotics | |
| GB732145A (en) | Improvements in or relating to a process for preparing pure potassium nitrate commercially free from chlorides and sodium salts | |
| GB799282A (en) | Purification of organic acids | |
| GB744019A (en) | Anhydrochlortetracycline and acid addition salts thereof |