GB718020A - Improvements in or relating to the recovery of the antibiotic oxytetracycline - Google Patents
Improvements in or relating to the recovery of the antibiotic oxytetracyclineInfo
- Publication number
- GB718020A GB718020A GB9892/51A GB989251A GB718020A GB 718020 A GB718020 A GB 718020A GB 9892/51 A GB9892/51 A GB 9892/51A GB 989251 A GB989251 A GB 989251A GB 718020 A GB718020 A GB 718020A
- Authority
- GB
- United Kingdom
- Prior art keywords
- barium
- magnesium
- oxytetracycline
- zinc
- calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Oxytetracycline (terramycin) is purified or isolated from a fermentation broth as a metal complex, which may then be converted into any desired therapeutic form of oxytetracycline, by adding to an aqueous solution of pH 7.0 to 10.0 at least one of the metals barium, strontium and calcium, and at least one of the metals magnesium, zinc, beryllium, cadmium and mercury. Specified complexes are of calcium-magnesium, barium - magnesium and barium - zinc; the barium-magnesium complex having the lowest solubility. In the case of a fermentation broth, which normally contains sufficient calcium and magnesium ions, it is preferred to adjust the pH of the filtered broth to 8.0 to 9.0 and to add barium ions, e.g. barium chloride. Iron, chromium and copper impurities are removed by dissolving the complex in dilute acid, e.g. sulphuric acid, adding a soluble ferrocyanide, e.g. potassium ferrocyanide, to precipitate the iron &c. and removing excess ferrocyanide by the addition of a soluble zinc or zirconium salt. Oxytetracycline is obtained by adjusting the filtrate to pH 7.0 with alkali. The precipitate is dissolved in methanol and concentrated hydrochloric acid added to produce the hydrochloride, which may be given a further purification with activated carbon. Specification 684,417 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US718020XA | 1950-06-01 | 1950-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB718020A true GB718020A (en) | 1954-11-10 |
Family
ID=22103679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9892/51A Expired GB718020A (en) | 1950-06-01 | 1951-04-27 | Improvements in or relating to the recovery of the antibiotic oxytetracycline |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB718020A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0126999A1 (en) | 1983-05-02 | 1984-12-05 | Biogal Gyogyszergyar | Process for making spherical crystalline 5-hydroxytetracycline hydrochloride (oxytetracycline hydrochloride) |
| EP0135604A1 (en) * | 1981-08-05 | 1985-04-03 | Biogal Gyogyszergyar | Process for the manufacture of an oxytetracycline calcium silicate complex salt from fermentation broths |
| CN105132512A (en) * | 2015-09-15 | 2015-12-09 | 河北健民淀粉糖业有限公司 | Method of reducing impurity tailing peak during terramycin production process |
-
1951
- 1951-04-27 GB GB9892/51A patent/GB718020A/en not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0135604A1 (en) * | 1981-08-05 | 1985-04-03 | Biogal Gyogyszergyar | Process for the manufacture of an oxytetracycline calcium silicate complex salt from fermentation broths |
| US4584135A (en) * | 1981-08-05 | 1986-04-22 | Biogal Gyogyszergyar | Process for the preparation of an oxytetracycline-calcium silicate complex salt from fermentation broth |
| EP0126999A1 (en) | 1983-05-02 | 1984-12-05 | Biogal Gyogyszergyar | Process for making spherical crystalline 5-hydroxytetracycline hydrochloride (oxytetracycline hydrochloride) |
| US4579686A (en) * | 1983-05-02 | 1986-04-01 | Biogal Gyogyszergyar | Process for the preparation of easy-flowing (flowable) oxytetracyclin hydrochloride |
| CN105132512A (en) * | 2015-09-15 | 2015-12-09 | 河北健民淀粉糖业有限公司 | Method of reducing impurity tailing peak during terramycin production process |
| CN105132512B (en) * | 2015-09-15 | 2018-07-31 | 河北健民淀粉糖业有限公司 | A kind of method that impurity tailing peak is reduced in terramycin production |
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