GB492095A - Improvements in or relating to insulin - Google Patents

Improvements in or relating to insulin

Info

Publication number
GB492095A
GB492095A GB381137A GB381137A GB492095A GB 492095 A GB492095 A GB 492095A GB 381137 A GB381137 A GB 381137A GB 381137 A GB381137 A GB 381137A GB 492095 A GB492095 A GB 492095A
Authority
GB
United Kingdom
Prior art keywords
insulin
solution
nickel
precipitate
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB381137A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Frederick Stearns & Co
Original Assignee
Frederick Stearns & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frederick Stearns & Co filed Critical Frederick Stearns & Co
Priority to GB381137A priority Critical patent/GB492095A/en
Publication of GB492095A publication Critical patent/GB492095A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Insulin, stated to be pure and to have a slower and more prolonged hypoglycemic effect than ordinary insulin, is obtained by adding to a solution of insulin a buffer, such as a salt of a strong base and a weak acid, in an amount of 1/5 to 1/40 molar, adding a water soluble salt of cadmium, nickel, calcium or cobalt with hydrochloric, acetic or tartaric acid, cooling the solution and recovering the precipitate. After the addition of the cadmium, nickel, calcium or cobalt salt an organic solvent, e.g. acetone to the amount of 12 per cent, is added, the solution heated to between 20 and 65 DEG C. cooled and separated from any flocculent precipitate, the pH is adjusted to between 5,6 and 6,4 and the solution is cooled to near freezing point, when a crystalline precipitate is formed which is the insulin product desired. In the instance of nickel chloride as the precipitating agent one part thereof to 10,000 of the mixture may be added. For use the insulin prepared as above is introduced into a buffer solution, e.g. of sodium phosphate, and brought to a pH approximately that of the body tissue.
GB381137A 1937-02-09 1937-02-09 Improvements in or relating to insulin Expired GB492095A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB381137A GB492095A (en) 1937-02-09 1937-02-09 Improvements in or relating to insulin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB381137A GB492095A (en) 1937-02-09 1937-02-09 Improvements in or relating to insulin

Publications (1)

Publication Number Publication Date
GB492095A true GB492095A (en) 1938-09-09

Family

ID=9765335

Family Applications (1)

Application Number Title Priority Date Filing Date
GB381137A Expired GB492095A (en) 1937-02-09 1937-02-09 Improvements in or relating to insulin

Country Status (1)

Country Link
GB (1) GB492095A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2626228A (en) * 1945-05-17 1953-01-20 Novo Terapeutisk Labor As Method of producing crystalline insulin
DE977674C (en) * 1950-04-05 1968-04-04 Novo Terapeutisk Labor As Process for the production of protracted, injectable insulin preparations

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2626228A (en) * 1945-05-17 1953-01-20 Novo Terapeutisk Labor As Method of producing crystalline insulin
DE977674C (en) * 1950-04-05 1968-04-04 Novo Terapeutisk Labor As Process for the production of protracted, injectable insulin preparations

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