Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB9903/50A
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Sharp and Dohme Inc
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Sharp and Dohme Inc
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Publication date
Application filed by Sharp and Dohme IncfiledCriticalSharp and Dohme Inc
Publication of GB667751ApublicationCriticalpatent/GB667751A/en
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Fatty acid salts of streptomycin and dihydrostreptomycin in which the fatty acid has not less than 5 and not more than 11 carbon atoms, particularly the propionate caprylate and undecylenate, are prepared by titrating the antibiotic base with the fatty acid to a pH of 6.5 to 7, if required with the addition of ethanol to facilitate solution of the fatty acid. In a preferred method, the sulphate or hydrochloride of streptomycin or dihydrostreptomycin is dissolved in water, electrodialyzed and the catholyte titrated with the fatty acid. The product is filtered and the salt obtained by freeze drying. Alternatively the base may be obtained by the use of an anion exchange resin.
GB9903/50A1949-09-201950-04-21Fatty acid salts of streptomycin and dihydrostreptomycin
ExpiredGB667751A
(en)