CH310171A - Process for the preparation of a pharmaceutically active compound. - Google Patents
Process for the preparation of a pharmaceutically active compound.Info
- Publication number
- CH310171A CH310171A CH310171DA CH310171A CH 310171 A CH310171 A CH 310171A CH 310171D A CH310171D A CH 310171DA CH 310171 A CH310171 A CH 310171A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- pharmaceutically active
- active compound
- phenoxy
- dimethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
@ Verfahren zur Herstellung einer pharmazeutisch wirksamen Verbindung.
Das Patent betrifft ein Verfahren zur Herstellung einer pharmazeutisch wirksamen Verbindung, das dadurch gekennzeichnet ist, dass man N, N-Dimethyl-} S- (o-benzyl-phenoxy)- äthilamin mit Methylbromid umsetzt. Das ent steheode quaternäre Ammoniumsalz der For me]
EMI1.1
ist wasserlöslich. Es soll aIs Antihistaminkör- per Verwendung finden.
Beispiel :
In eine Lösung von 30 g N,N-Dimethyl-¯ (o-benzyl-phenoxy)-äthylamin in 70 ml Iso propanol leitet man unter Kühlung 6, 5 g Me thylchlorid ein. Die sofort ausfallende feste Verbindung wird abfiltriert und aus Wasser umkristallisiert. Man erhält in nahezu quan titativer Ausbeute B-(o-Benzyl-phenoxy)-äthyl- trimethylammoniumchlorid.
PATENTANSPRUCH :
Verfahren zur Herstellung einer pharmazeutisch wirksamen Verbindung, dadurch gekennzeichnet, dass man N,N-Dimethyl-¯-(obenzyl-phenoxy)-äthylamin mit Methylchlorid umsetzt. Das entstehende quaternäre Ammoniumsalz der Formel
EMI1.2
ist wasserlöslich.
**WARNUNG** Ende DESC Feld konnte Anfang CLMS uberlappen**.
@ Process for the preparation of a pharmaceutically active compound.
The patent relates to a process for the preparation of a pharmaceutically active compound which is characterized in that N, N-dimethyl-} S- (o-benzyl-phenoxy) -ethelamine is reacted with methyl bromide. The resulting quaternary ammonium salt of the form]
EMI1.1
is water soluble. It is said to be used as an antihistamine body.
Example:
6.5 g of methyl chloride are introduced into a solution of 30 g of N, N-dimethyl-¯ (o-benzyl-phenoxy) -ethylamine in 70 ml of isopropanol, with cooling. The solid compound which precipitates out immediately is filtered off and recrystallized from water. B- (o-benzylphenoxy) ethyl trimethylammonium chloride is obtained in almost quantitative yield.
PATENT CLAIM:
Process for the preparation of a pharmaceutically active compound, characterized in that N, N-dimethyl-¯- (above-zyl-phenoxy) -ethylamine is reacted with methyl chloride. The resulting quaternary ammonium salt of the formula
EMI1.2
is water soluble.
** WARNING ** End of DESC field could overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US310171XA | 1949-11-17 | 1949-11-17 | |
US300850XA | 1950-08-30 | 1950-08-30 | |
CH308146T | 1950-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH310171A true CH310171A (en) | 1955-09-30 |
Family
ID=27178312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH310171D CH310171A (en) | 1949-11-17 | 1950-11-14 | Process for the preparation of a pharmaceutically active compound. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH310171A (en) |
-
1950
- 1950-11-14 CH CH310171D patent/CH310171A/en unknown
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