GB708158A - Improvements in or relating to salts of dihydrostreptomycin - Google Patents
Improvements in or relating to salts of dihydrostreptomycinInfo
- Publication number
- GB708158A GB708158A GB11131/52A GB1113152A GB708158A GB 708158 A GB708158 A GB 708158A GB 11131/52 A GB11131/52 A GB 11131/52A GB 1113152 A GB1113152 A GB 1113152A GB 708158 A GB708158 A GB 708158A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dihydrostreptomycin
- salt
- acid salt
- water
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
A mixed inorganic acid salt of dihydrostreptomycin is prepared by adding to an aqueous solution of a single acid salt of dihydrostreptomycin at least one molar equivalent, and preferably about two, of a water-soluble salt having a different inorganic anion and a cation which is capable of producing a water-soluble inorganic salt with the acid of the dihydrostreptomycin. The mixed acid salt of dihydrostreptomycin may contain two or three anions, one of which may be trivalent, e.g. phosphate, the others are mono- or divalent. A salt containing a monovalent anion and a divalent anion is preferred. Specified anions are sulphate, sulphite, hydrosulphite, thiosulphate, chloride, bromide, iodide, chlorate, bromate, nitrate, nitrite, and thiocyanate. Preferred water-soluble salts are the alkali metal, ammonium and organic ammonium salts of the above anions. The initial aqueous solution has a potency of at least 80,000 mcg./ml. and preferably at least 200,000 mcg./ml. Excess water-soluble salt is used to reduce the solubility in water of the mixed acid salt or dihydrostreptomycin. Crystallization is enhanced by cooling and seeding. The mixed acid salt may also be formed by adding the chosen anions, as acids, to the base dihydrostreptomycin. The mixed acid salts of streptomycin or mannosido-dihydrostreptomycin are not formed in the above manner. A crude dihydrostreptomycin obtained by adsorbing streptomycin from a filtered culture broth on to an ion-exchange resin, eluting and hydrogenating with Raney nickel catalyst is purified by forming its mixed acid salt in the above manner. Among specific salts are dihydrostreptomycin sulphate-iodide, dihydrostreptomycin sulphitebromide and dihydrostreptomycin sulphiteiodide.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US708158XA | 1951-05-04 | 1951-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB708158A true GB708158A (en) | 1954-04-28 |
Family
ID=22097546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB11131/52A Expired GB708158A (en) | 1951-05-04 | 1952-05-02 | Improvements in or relating to salts of dihydrostreptomycin |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB708158A (en) |
-
1952
- 1952-05-02 GB GB11131/52A patent/GB708158A/en not_active Expired
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