GB894752A - Improvements in or relating to citric acid derivatives - Google Patents
Improvements in or relating to citric acid derivativesInfo
- Publication number
- GB894752A GB894752A GB10124/60A GB1012460A GB894752A GB 894752 A GB894752 A GB 894752A GB 10124/60 A GB10124/60 A GB 10124/60A GB 1012460 A GB1012460 A GB 1012460A GB 894752 A GB894752 A GB 894752A
- Authority
- GB
- United Kingdom
- Prior art keywords
- citryl
- acid
- trigluconic
- calcium
- iron
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
- C07C69/704—Citric acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises citryl trigluconic acid, isolated as a syrup which has not been completely freed from water, and metal salts including calcium, magnesium and iron citryl trigluconates. Citryl trigluconic acid is made by reacting citric acid and gluconic acid or glucono-8-lactone in the proportion of approximately three moles of gluconic acid or lactone per mole of citric acid in aqueous solution at a temperature within the range from about 80 DEG C. to 110 DEG C. The metal salts may be made by reacting the citryl trigluconic acid in aqueous solution with an alkaline compound of the corresponding metal, for example, an oxide, hydroxide or carbonate, diluting the resulting solution with a watermiscible organic liquid in which the salt is insoluble in sufficient amount to precipitate the salt, and recovering the resulting precipitate. Citryl trigluconic acid finds many uses as a sequestering agent, and the metal salts may be used to remedy nutritive deficiencies.ALSO:Metal salts of citryl trigluconic acid may be used in aqueous solutions in compositions used to remedy nutritive deficiencies, such as calcium, magnesium and iron deficiencies, by injection or oral administration. For example, the calcium salt may be supplied in physiological saline containing 1 gm. of calcium citryl trigluconate per 10 c.c. A composition for injection may contain thiamine hydrochloride, liver extract and calcium citryl trigluconate. The magnesium salts are useful as laxatives alone and in conjunction with antacid mixtures. They may also be employed for parenteral administration as anticonvulsants, central depressants or dehydrants. The iron salts may be used as iron supplements for oral or intravenous administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US894752XA | 1959-05-20 | 1959-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB894752A true GB894752A (en) | 1962-04-26 |
Family
ID=22217850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB10124/60A Expired GB894752A (en) | 1959-05-20 | 1960-03-22 | Improvements in or relating to citric acid derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB894752A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992016493A1 (en) * | 1991-03-16 | 1992-10-01 | Basf Aktiengesellschaft | Citric acid esters of polyhydroxyle compounds and their use in washing and cleaning products |
-
1960
- 1960-03-22 GB GB10124/60A patent/GB894752A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992016493A1 (en) * | 1991-03-16 | 1992-10-01 | Basf Aktiengesellschaft | Citric acid esters of polyhydroxyle compounds and their use in washing and cleaning products |
| US5508394A (en) * | 1991-03-16 | 1996-04-16 | Basf Aktiengesellschaft | Citric esters of polyhydroxy compounds and use thereof in detergents |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1038678A (en) | Compounds having an adrenocorticotrophic hormone action and process for their manufacture | |
| GB894752A (en) | Improvements in or relating to citric acid derivatives | |
| GB748024A (en) | Improved therapeutic preparations of iron | |
| US2117777A (en) | Double salts of calcium ascorbate with calcium salts of other polyhydroxy-mono-carboxylic acids and process of making them | |
| US2388261A (en) | Riboflavin solution | |
| GB934292A (en) | Process for the preparation of heterocyclic compounds | |
| GB715976A (en) | Improvements in medical preparations for removing toxic heavy metals from the human body | |
| GB972672A (en) | Pharmaceutical preparations containing compounds of the androstane series | |
| GB1033736A (en) | Stable injectable protamine-active compositions | |
| GB914524A (en) | Thiazole carboxylic acid-(5-nitrofuryl-2-methylidene)-hydrazides and process for their manufacture | |
| IE34307B1 (en) | New 1-alkyl-6-azauracil compounds and preparations which contain a 1-alkyl-6-azauracil compound as an active ingredient | |
| US2516276A (en) | Method of preparing arsenic compounds | |
| GB816592A (en) | A method for the preparation of stable magnesium solutions of high concentration | |
| GB923942A (en) | New compounds, processes for preparing them and pharmaceutical compositions containing them | |
| GB700774A (en) | Stabilised aqueous solutions of sodium p-aminosalicylate and production of the same | |
| US2339787A (en) | Substituted para-aminobenzene sulphonamide compound | |
| US2143829A (en) | Water soluble derivative of p-aminobenzenesulphonamide | |
| GB1199758A (en) | Arylsulphonyl-Semicarbazides and their production | |
| GB823242A (en) | Therapeutic compositions containing choline salts of dialkyl xanthines | |
| GB474518A (en) | Improvements in or relating to cleansing agents | |
| GB527864A (en) | A process for the production of readily soluble calcium salts | |
| GB815877A (en) | Improvements in or relating to bismuth salts | |
| GB967475A (en) | Improvements in or relating to pharmaceutical compositions comprising a salt of (n-methylene-sulphoxylate)-4-amino-2-hydroxybenzoic acid | |
| GB839838A (en) | Improvements in or relating to the preparation of cobalt compounds | |
| GB667751A (en) | Fatty acid salts of streptomycin and dihydrostreptomycin |