GB583221A - Improvements in the manufacture of mepacrine hydrochloride - Google Patents
Improvements in the manufacture of mepacrine hydrochlorideInfo
- Publication number
- GB583221A GB583221A GB963643A GB963643A GB583221A GB 583221 A GB583221 A GB 583221A GB 963643 A GB963643 A GB 963643A GB 963643 A GB963643 A GB 963643A GB 583221 A GB583221 A GB 583221A
- Authority
- GB
- United Kingdom
- Prior art keywords
- mepacrine
- per cent
- aqueous
- base
- hydrochloric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
- C07D219/12—Amino-alkylamino radicals attached in position 9
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Mepacrine Hydroxhloride, i.e. the dihydrate of 2-methoxy-6-chloro-9-(41-diethylamino-11 -methylbutylamino)-acridine dihydrochloride is obtained by adding hydrogen chloride to mepacrine base in aqueous acetic or formic acid solution, whereby the Mepacrine Hydrochloride is precipitated. Advantaneously, the quantities of the starting-materials are so adjusted that the concentrations of the components in the final liquor from which the precipitation takes place are: mepacrine (calculated as base) 5 to 20 per cent, free hydrochloric acid 2.5 to 10 per cent, acetic acid 10 to 20 per cent (or formic acid 5 to 10 per cent), these percentages being calculated weight for weight of the total liquor obtained when hydrochloric acid is rapidly added to the slowly stirred mepacrine acetate (or formate) solution at about 25 DEG C. In examples, Mepacrine Hydrochloride is obtained by: (1) preparing mepacrine base by the reaction described in example 2 of Specification 583,220, treating the reaction mass with a mixture of benzene and aqueous 15 per cent caustic soda solution and extracting the mepacrine as acetate from the benzene layer by treatment with aqueous 20 per cent acetic acid; thereafter the aqueous mepacrine acetate is rapidly treated with concentrated hydrochloric acid at 25 DEG C. to precipitate Mepacrine Hydrochloride; (2) extracting the Mepacrine as formate from the benzene solution of mepacrine base, prepared as in (1), by treatment with aqueous 15 per cent formic acid and adding concentrated hydrochloric acid as in (1) to the aqueous mepacrine formate. Specification 363,392 also is referred to.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB963643A GB583221A (en) | 1943-06-16 | 1943-06-16 | Improvements in the manufacture of mepacrine hydrochloride |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB963643A GB583221A (en) | 1943-06-16 | 1943-06-16 | Improvements in the manufacture of mepacrine hydrochloride |
Publications (1)
Publication Number | Publication Date |
---|---|
GB583221A true GB583221A (en) | 1946-12-12 |
Family
ID=9875817
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB963643A Expired GB583221A (en) | 1943-06-16 | 1943-06-16 | Improvements in the manufacture of mepacrine hydrochloride |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB583221A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2702937A (en) * | 1950-10-17 | 1955-03-01 | Gordon E Smart | Rod machine and process |
-
1943
- 1943-06-16 GB GB963643A patent/GB583221A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2702937A (en) * | 1950-10-17 | 1955-03-01 | Gordon E Smart | Rod machine and process |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB662800A (en) | Improvements in or relating to the preparation of salts of cyclohexylsulphamic acid | |
GB583221A (en) | Improvements in the manufacture of mepacrine hydrochloride | |
GB497771A (en) | A process for the preparation of wash out reliefs | |
US1906873A (en) | Method for the reduction of furfural and furan derivatives | |
GB761093A (en) | Production of s-acetyl glutathione | |
GB579459A (en) | Process for the purification of 4-hydroxycoumarins | |
GB953387A (en) | 5-allyl-5-(ª-hydroxypropyl)-barbituric acid and a process for the production thereof | |
GB932523A (en) | Process for the production of lead hydroxide oxide of the formula 5 pbo.2ho | |
US1765660A (en) | Reduction of aromatic nitro compounds | |
GB607445A (en) | A process for the manufacture of zinc peroxide | |
US2568462A (en) | 2,4-diamino-6-omega-carboxytrihydroxypropylpteridine | |
GB514592A (en) | Improvements in and relating to the manufacture of cyclic ketones | |
GB255892A (en) | A process for the production of organic arseno compounds | |
GB701179A (en) | An improved method of manufacturing 3-picoline | |
McClelland et al. | CCCLVIII.—The formation of aromatic thiosulphonic acids from disulphides | |
GB501542A (en) | Improvements in process of glutamic acid production | |
GB517747A (en) | Manufacture of aminohydrazines | |
GB495892A (en) | Process for the production of salts of thiocyanic acid | |
GB616454A (en) | Improvements in or relating to the preparation of basic lead salts of 2:4 dinitro resorcinol | |
GB914428A (en) | Process for the production of ª-, ª--dichloropropionic acid | |
GB470468A (en) | Improvements in the manufacture and production of ureas from alpha-omega-diaminocarboxylic acids | |
GB225824A (en) | A process for the preparation of dihydrocodeinone from thebaine | |
GB492095A (en) | Improvements in or relating to insulin | |
GB634909A (en) | Process for the preparation of amines having the ring system of lysergic acid or dihydrolysergic acid | |
GB586133A (en) | Improvements in or relating to the recovery of crotonic acid |