GB599688A - Improvements in or relating to the production of pyrazine derivatives - Google Patents
Improvements in or relating to the production of pyrazine derivativesInfo
- Publication number
- GB599688A GB599688A GB16513/44A GB1651344A GB599688A GB 599688 A GB599688 A GB 599688A GB 16513/44 A GB16513/44 A GB 16513/44A GB 1651344 A GB1651344 A GB 1651344A GB 599688 A GB599688 A GB 599688A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carboxypyrazine
- hydroxy
- lumazine
- sodium hydroxide
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
2-Hydroxy-3-carboxypyrazine compounds are manufactured by treating lumazine, an alkyl-or phenyl-substituted lumazine or phenanthralumazine in aqueous solution with at least three molecular proportions of an alkali metal hydroxide so as to form exclusively or in preponderant amount an alkali metal salt of a corresponding 2 - hydroxy - 3 - carboxypyrazine, and isolating this salt or converting it into the free acid, e.g. by direct acidification or by way of the barium salt. In an example, lumazine is heated to 170 DEG C. in a bomb with just under four molecular proportions of aqueous sodium hydroxide and the reaction mixture is acidified to pH 2.5-3 with hydrochloric acid to liberate 2 - hydroxy - 3 - carboxypyrazine. The sodium hydroxide may be replaced by potassium hydroxide. The Specification as open to inspection under Sect. 91 comprises also the subject-matter of Specification 599,689, and an additional example in which 2-amino-3-carboxypyrazine is heated to 170 DEG C. in a steel bomb with aqueous sodium hydroxide and the product is acidified with hydrochloric acid to liberate 2-hydroxy-3-carboxypyrazine. This subject-matter does not appear in the Specification as accepted.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US599688XA | 1943-09-18 | 1943-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB599688A true GB599688A (en) | 1948-03-18 |
Family
ID=22026476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB16513/44A Expired GB599688A (en) | 1943-09-18 | 1944-08-30 | Improvements in or relating to the production of pyrazine derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB599688A (en) |
-
1944
- 1944-08-30 GB GB16513/44A patent/GB599688A/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB599688A (en) | Improvements in or relating to the production of pyrazine derivatives | |
| GB934292A (en) | Process for the preparation of heterocyclic compounds | |
| GB599689A (en) | Improvements in or relating to the production of pyrazine derivatives | |
| GB578682A (en) | Improvements in the process of making sulphaguanidine | |
| GB896089A (en) | Derivatives of thiamine and their production | |
| GB870575A (en) | Benzothiadiazines and the production thereof | |
| GB1022733A (en) | Triaminobenzene | |
| GB573478A (en) | Improvements in or relating to the manufacture of chlorocresol derivatives | |
| GB887012A (en) | Process for the preparation of 18ª--glycyrrhetinic acid | |
| GB571628A (en) | Production of unsubstituted or ª‡,ª‡-substituted ª‰,ª‰-thiodihydracrylic acids | |
| GB579001A (en) | Manufacture of new derivatives of 4:4-diamino-diphenylsulphones | |
| GB599686A (en) | Improvements in or relating to the production of pyrazine derivatives | |
| GB596640A (en) | Improvements in or relating to the manufacture of quinoxaline compounds | |
| GB583005A (en) | Improvements in or relating to the production of loose fur for felt manufacture | |
| GB612385A (en) | Improvements in or relating to the production of para-aminobenzenesulphonamidohalopyrazines | |
| GB597889A (en) | The manufacture of 2-amino-5-methyl pyrazine | |
| GB474842A (en) | Process of obtaining a new thio-barbituric acid compound | |
| GB771484A (en) | Preparation of -ß-aminomethyltropolone | |
| GB592682A (en) | Process of transforming vanillin to vanillic acid | |
| GB628757A (en) | Improvements in the production of gelatin | |
| GB433142A (en) | Improved manufacture of cosmetic preparations | |
| GB470468A (en) | Improvements in the manufacture and production of ureas from alpha-omega-diaminocarboxylic acids | |
| GB617420A (en) | Method of preparing aqueous suspensions of magnesia | |
| GB393240A (en) | Manufacture of oxydiphenyl-ether-carboxylic acids | |
| GB169025A (en) | Improvements in or relating to the manufacture of chlorinated derivatives of toluene |