GB612385A - Improvements in or relating to the production of para-aminobenzenesulphonamidohalopyrazines - Google Patents

Improvements in or relating to the production of para-aminobenzenesulphonamidohalopyrazines

Info

Publication number
GB612385A
GB612385A GB15779/46A GB1577946A GB612385A GB 612385 A GB612385 A GB 612385A GB 15779/46 A GB15779/46 A GB 15779/46A GB 1577946 A GB1577946 A GB 1577946A GB 612385 A GB612385 A GB 612385A
Authority
GB
United Kingdom
Prior art keywords
chloropyrazine
sulphanilamido
dichloropyrazines
prepared
heating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB15779/46A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB612385A publication Critical patent/GB612385A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C07D241/22—Benzenesulfonamido pyrazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)

Abstract

An aminobenzenesulphonamido-halopyrazine is prepared by heating a mixture of an aminobenzenesulphonamide and a polyhalopyrazine, preferably in presence of an acid-binding substance such as an alkali carbonate, and preferably within the temperature range of 125-160 DEG C. Examples are given of the preparation of 2 - sulphanilamido - 3 - chloropyrazine, 2 - sulphanilamido - 5 - chloropyrazine, 2 - sulphanilamido-6-chloropyrazine, and 2-metanilamido-5-chloropyrazine. Dichloropyrazines are prepared by vaporizing an aqueous solution of pyrazine, mixing with chlorine and heating in a glass or stainless steel tube for 2-3 seconds at 400-500 DEG C. The fraction of the oily product boiling between 94 DEG and 107 DEG C. at 50 mm. pressure contains the 2,3-, 2,5- and 2,6-dichloropyrazines, which may then be separated by fractional crystallization by cooling.
GB15779/46A 1945-06-26 1946-05-24 Improvements in or relating to the production of para-aminobenzenesulphonamidohalopyrazines Expired GB612385A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US612385XA 1945-06-26 1945-06-26

Publications (1)

Publication Number Publication Date
GB612385A true GB612385A (en) 1948-11-11

Family

ID=22034523

Family Applications (1)

Application Number Title Priority Date Filing Date
GB15779/46A Expired GB612385A (en) 1945-06-26 1946-05-24 Improvements in or relating to the production of para-aminobenzenesulphonamidohalopyrazines

Country Status (1)

Country Link
GB (1) GB612385A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE951929C (en) * 1952-10-23 1956-11-08 Ciba Geigy Process for the preparation of 6- (p-Amino-benzenesulfonamido) -3-halopyridazines
DE1204233B (en) * 1960-03-14 1965-11-04 Farmaceutici Italia Process for the preparation of 2- (p-Amino-benzenesulfonamido) -3-methoxy-pyrazine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE951929C (en) * 1952-10-23 1956-11-08 Ciba Geigy Process for the preparation of 6- (p-Amino-benzenesulfonamido) -3-halopyridazines
DE1204233B (en) * 1960-03-14 1965-11-04 Farmaceutici Italia Process for the preparation of 2- (p-Amino-benzenesulfonamido) -3-methoxy-pyrazine

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