GB606482A - Improvements in and relating to the purification of penicillin salts - Google Patents
Improvements in and relating to the purification of penicillin saltsInfo
- Publication number
- GB606482A GB606482A GB274046A GB274046A GB606482A GB 606482 A GB606482 A GB 606482A GB 274046 A GB274046 A GB 274046A GB 274046 A GB274046 A GB 274046A GB 606482 A GB606482 A GB 606482A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- solvent
- acetone
- cyclohexylamine
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Pure penicillin is prepared by a process in which free penicillin dissolved in a solvent is treated with a primary amine. The resultant precipitate of a penicillin primary amine salt may be converted into corresponding metallic salts. It has been found desirable to dissolve the penicillin in a main solvent, subsequently to add a secondary solvent and finally to add the primary amine. Suitable primary amines are cyclohexylamine, 2, 3 or 4 methyl cyclohexyl amine, monoethylamine, isopropylamine and n-butylamine. Preferred main solvents are ether, amyl acetate, methyl isobutyl ketone and, using a modified process, chloroform. Preferred secondary solvents are ethyl alcohol, acetone and methyl ethyl ketone. In examples: (I) and (IV) an ethereal extract of an acidified penicillin solution was diluted with acetone and treated with cyclohexylamine; (II) the cyclohexylamine salt was similarly prepared using methyl isobutyl ketone as the solvent, and (III) the isopropylamine salt was prepared using ether as the main solvent with acetone as a secondary solvent.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB274046A GB606482A (en) | 1946-01-28 | 1946-01-28 | Improvements in and relating to the purification of penicillin salts |
ES176397A ES176397A1 (en) | 1946-01-28 | 1947-01-11 | A PROCEDURE TO SEPARATE PENICILLIN SALTS IN GREAT CONDITION OF PURITY |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB274046A GB606482A (en) | 1946-01-28 | 1946-01-28 | Improvements in and relating to the purification of penicillin salts |
Publications (1)
Publication Number | Publication Date |
---|---|
GB606482A true GB606482A (en) | 1948-08-13 |
Family
ID=9744985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB274046A Expired GB606482A (en) | 1946-01-28 | 1946-01-28 | Improvements in and relating to the purification of penicillin salts |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES176397A1 (en) |
GB (1) | GB606482A (en) |
-
1946
- 1946-01-28 GB GB274046A patent/GB606482A/en not_active Expired
-
1947
- 1947-01-11 ES ES176397A patent/ES176397A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES176397A1 (en) | 1947-03-01 |
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