GB732559A - A new amine salt of penicillin g - Google Patents
A new amine salt of penicillin gInfo
- Publication number
- GB732559A GB732559A GB2155352A GB2155352A GB732559A GB 732559 A GB732559 A GB 732559A GB 2155352 A GB2155352 A GB 2155352A GB 2155352 A GB2155352 A GB 2155352A GB 732559 A GB732559 A GB 732559A
- Authority
- GB
- United Kingdom
- Prior art keywords
- salt
- penicillin
- beta
- benzyl
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Abstract
The N-benzyl-beta-phenylethylamine salt of penicillin G is prepared by reacting penicillin G ions with N-benzyl-beta-phenylethylamine ions in a solvent in which the said salt is relatively insoluble whilst the starting materials are more soluble than the said salt. The salt may be prepared by reacting (a) the free amine with the free penicillin G in the presence of a solvent such as t-butanol, acetone, or ethyl, butyl or amyl acetate; (b) a salt of the amine, e.g. hydrochloride with a salt of penicillin G, e.g. sodium salt in the presence of water; and (c) the free penicillin with the salt of the amine and an aliphatic or substituted aliphatic acid containing not more than 8 carbon atoms in a straight chain, e.g. formic, acetic, propionic, butyric, isobutyric, isocaproic, caprylic, 2-ethylhexoic, phenylacetic, glycollic or malonic acids, in the presence of an organic solvent such as diethyl ether, methyl isobutyl ketone, or ethyl, butyl or amyl acetate. The salt may be used in the purification of penicillin from e.g. solvent extracts, buffered alkaline extracts and crystallization mother liquors. It is used in medicine (see Group VI) and is an animal feed supplement (see Group I).ALSO:The N-benzyl-beta-pehnylethylamine salt of penicillin G (see Group IV (b)) is sufficiently stable to be useful as a supplement to animal feeds.ALSO:The N-benzyl-beta-phenylethylamine salt of penicillin G (see Group IV (b)) may be administered (a) orally in a flavoured mixture, or (b) injected in an aqueous medium containing polyoxyethylene monoleate.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2155352A GB732559A (en) | 1952-08-27 | 1952-08-27 | A new amine salt of penicillin g |
| ES0211030A ES211030A1 (en) | 1952-08-27 | 1953-08-26 | A new amine salt of penicillin g |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2155352A GB732559A (en) | 1952-08-27 | 1952-08-27 | A new amine salt of penicillin g |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB732559A true GB732559A (en) | 1955-06-29 |
Family
ID=10164840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2155352A Expired GB732559A (en) | 1952-08-27 | 1952-08-27 | A new amine salt of penicillin g |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES211030A1 (en) |
| GB (1) | GB732559A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331599A (en) | 1981-02-02 | 1982-05-25 | Pfizer Inc. | Sparingly water-soluble salts of penicillanic acid 1,1-dioxide |
-
1952
- 1952-08-27 GB GB2155352A patent/GB732559A/en not_active Expired
-
1953
- 1953-08-26 ES ES0211030A patent/ES211030A1/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331599A (en) | 1981-02-02 | 1982-05-25 | Pfizer Inc. | Sparingly water-soluble salts of penicillanic acid 1,1-dioxide |
| EP0057606B1 (en) * | 1981-02-02 | 1985-05-02 | Pfizer Inc. | Salts of penicillanic acid 1,1-dioxide |
Also Published As
| Publication number | Publication date |
|---|---|
| ES211030A1 (en) | 1954-01-01 |
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