GB647861A - A process for the manufacture of salts of physiologically active, nitrogenous bases - Google Patents
A process for the manufacture of salts of physiologically active, nitrogenous basesInfo
- Publication number
- GB647861A GB647861A GB1721548A GB1721548A GB647861A GB 647861 A GB647861 A GB 647861A GB 1721548 A GB1721548 A GB 1721548A GB 1721548 A GB1721548 A GB 1721548A GB 647861 A GB647861 A GB 647861A
- Authority
- GB
- United Kingdom
- Prior art keywords
- mucamic
- hydrogen
- acid
- mucamate
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C07D489/04—Salts; Organic complexes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Salts are made from mucamic acid and one of the following bases:- morphine, diamorphine, dihydromorphinone, methyldihydromorphinone, amidone, hyoseine and its amino oxide, hyoxyamine and its amino oxide, atropine and its amino oxide, ergometrine, D-tubocurarine and its alkyl ethers (e.g. dimethyl) and alkyl esters, compounds of the general formula <FORM:0647861/IV (b)/1> where R1 is hydrogen, aryl, hydroxy or alkoxy, R2 is hydrogen, hydroxy or alkoxy, R3 is hydrogen, hydroxy or alkoxy, R4 is hydrogen or alkyl and R5 is hydrogen or alkyl (e.g. adrenaline), procaine, amethocaine and neostigmine. The salts are produced by direct reaction between the base and mucamic acid or by double decomposition between a salt of the base and an alkali, alkaline earth, magnesium, ammonium or silver mucamate. The products may be obtained in solid form by concentrating their aqueous solutions under reduced pressure and drying in vacuo or by freeze-drying. Examples are given.ALSO:Therapeutic solutions of mucamates of organic bases are made containing excess of mucamic acid for stability or excess of alkali mucamate to adjust the tonicity. Examples show solutions of mucamic acid with the mucamates of adrenaline, D-tubocurarine, procaine, amidone, morphine, ergometrine and isopropyl noi-adrenaline, and a solution containing neostigmine mucamate, mucamic acid and sodium mucamate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1721548A GB647861A (en) | 1948-06-25 | 1948-06-25 | A process for the manufacture of salts of physiologically active, nitrogenous bases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1721548A GB647861A (en) | 1948-06-25 | 1948-06-25 | A process for the manufacture of salts of physiologically active, nitrogenous bases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB647861A true GB647861A (en) | 1950-12-20 |
Family
ID=10091248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1721548A Expired GB647861A (en) | 1948-06-25 | 1948-06-25 | A process for the manufacture of salts of physiologically active, nitrogenous bases |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB647861A (en) |
-
1948
- 1948-06-25 GB GB1721548A patent/GB647861A/en not_active Expired
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