Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB37180/46A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
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Filing date
Publication date
Application filed by Merck and Co IncfiledCriticalMerck and Co Inc
Publication of GB630264ApublicationCriticalpatent/GB630264A/en
C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
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Chemical & Material Sciences
(AREA)
Organic Chemistry
(AREA)
Cephalosporin Compounds
(AREA)
Abstract
Lower alkyl esters of penicillin G are manufactured by reacting penicillin G with a lower diazoalkane, e.g. diazomethane or diazoethane. The reaction is preferably effected by adding excess of the diazoalkane to an ethereal solution of penicillin G, preferably in substantially pure form as obtained by acidifying an aqueous solution of crystalline sodium penicillin G, and extracting with ether. Examples describe the preparation of the methyl ester.
GB37180/46A1945-12-201946-12-17Process for preparing esters of penicillin g
ExpiredGB630264A
(en)