GB600719A - Improvements in or relating to the production of sodium-penicillin - Google Patents
Improvements in or relating to the production of sodium-penicillinInfo
- Publication number
- GB600719A GB600719A GB17989/44A GB1798944A GB600719A GB 600719 A GB600719 A GB 600719A GB 17989/44 A GB17989/44 A GB 17989/44A GB 1798944 A GB1798944 A GB 1798944A GB 600719 A GB600719 A GB 600719A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- sodium
- extracting
- aqueous solution
- acidifying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/14—Preparation of salts
- C07D499/16—Preparation of salts of alkali or alkaline earth metals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Crystalline sodium penicillin is prepared by crystallizing a partially purified amorphous sodium penicillin (e.g. the product of Specification 593,691) from an aliphatic alcohol having not more than six carbon atoms in the molecule (e.g. methanol or ethanol), advantageously by precipitation of the crystals from the alcoholic solution by the addition of an alcohol-miscible organic non-solvent for sodium penicillin (e.g. ethyl acetate or acetone). The product may be used for the preparation, in substantially pure form, of penicillin salts of other metals, such as the calcium salt (e.g. by acidifying an aqueous solution of the sodium salt, extracting with ether and re-extracting with an aqueous solution of calcium hydroxide or an aqueous suspension of calcium carbonate), of free acid penicillin (e.g. by acidifying an aqueous solution of the sodium salt with dilute phosphoric acid, extracting with ether, drying the extract and evaporating in vacuo) or of penicillin esters (e.g. by treating the foregoing dried ethereal extract with a diazoalkane, e.g. diazomethane).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US600719XA | 1943-08-06 | 1943-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB600719A true GB600719A (en) | 1948-04-16 |
Family
ID=22027137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB17989/44A Expired GB600719A (en) | 1943-08-06 | 1944-09-20 | Improvements in or relating to the production of sodium-penicillin |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB600719A (en) |
-
1944
- 1944-09-20 GB GB17989/44A patent/GB600719A/en not_active Expired
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