GB880573A - Process for the manufacture of the tetrahydrate or salts of cocarboxylase - Google Patents

Process for the manufacture of the tetrahydrate or salts of cocarboxylase

Info

Publication number
GB880573A
GB880573A GB30741/58A GB3074158A GB880573A GB 880573 A GB880573 A GB 880573A GB 30741/58 A GB30741/58 A GB 30741/58A GB 3074158 A GB3074158 A GB 3074158A GB 880573 A GB880573 A GB 880573A
Authority
GB
United Kingdom
Prior art keywords
cocarboxylase
solution
tetrahydrate
aneurin
exchange resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB30741/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck KGaA
Original Assignee
E Merck AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E Merck AG filed Critical E Merck AG
Publication of GB880573A publication Critical patent/GB880573A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00—Ion-exchange processes in general; Apparatus therefor
    • B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises the tetrahydrate, hydrobromide, hydriodide, nitrate, sulphate, sulphanilate and naphthalene-b -sulphonate of cocarboxylase (aneurin pyrophosphoric ester), and the preparation thereof and of other salts of cocarboxylase by dissolving in water the mixture of orthophosphoric acid and various phosphoric acid esters of aneurin obtained by phosphorylation of aneurin, obtaining from this solution with the aid of one or more suitable ion exchange resins an aqueous solution of cocarboxylase tetrahydrate, isolating this compound in crystalline form therefrom by removal of the solvent water or preferably by addition of a precipitating agent (e.g. a lower alcohol or acetone) and, if desired, converting the crystalline tetrahydrate into a salt of cocarboxylase by treatment with an acid. The solution from which the cocarboxylase tetrahydrate is crystallized may be obtained by adding a precipitating agent to the aqueous solution of the phosphorylation mixture, redissolving and reprecipating two or three times, if desired, and dissolving the resulting syrup in a little water, and then: (a) passing the solution over a weakly basic anion exchange resin and separating the portion off the eluate running off at pH5.5 to 1; or (b) passing the original solution or that obtained according to (a) over a strongly basic anion exchange resin and separating the portion of the eluate running off at pH 5.5 to 1; or (c) passing the solution obtained according to (a) over a cation exchange resin (which retains aneurin orthophosphoric ester and allows a purified solution of cocarboxylase tetrahydrate to run through. Aneurin orthophosphoric ester may be subsequently eluted with 10% hydrochloric acid, and is also obtainable as a by-product in (a) and (b)). Alternatively, an aqueous solution of a cocarboxylase salt, especially one still containing impurities, may be treated with an ion exchange resin, preferably an anion exchange resin. Specifications 687,673, 687,674 and 793,753 are referred to.
GB30741/58A 1957-09-28 1958-09-25 Process for the manufacture of the tetrahydrate or salts of cocarboxylase Expired GB880573A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE880573X 1957-09-28

Publications (1)

Publication Number Publication Date
GB880573A true GB880573A (en) 1961-10-25

Family

ID=6823552

Family Applications (1)

Application Number Title Priority Date Filing Date
GB30741/58A Expired GB880573A (en) 1957-09-28 1958-09-25 Process for the manufacture of the tetrahydrate or salts of cocarboxylase

Country Status (1)

Country Link
GB (1) GB880573A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101787049A (en) * 2009-09-23 2010-07-28 北京京卫信康医药科技发展有限公司 Novel crystal form of cocarboxylase tetrahydrate and preparation method thereof
CN101787048A (en) * 2009-09-23 2010-07-28 北京京卫信康医药科技发展有限公司 Preparation method of cocarboxylase tetrahydrate
CN103351407A (en) * 2012-07-23 2013-10-16 四川海思科制药有限公司 Novel crystal form of cocarboxylase tetrahydrate
CN113402555A (en) * 2020-03-17 2021-09-17 上海医药工业研究院 Preparation method of cocarboxylase and tetrahydrate or salt thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101787049A (en) * 2009-09-23 2010-07-28 北京京卫信康医药科技发展有限公司 Novel crystal form of cocarboxylase tetrahydrate and preparation method thereof
CN101787048A (en) * 2009-09-23 2010-07-28 北京京卫信康医药科技发展有限公司 Preparation method of cocarboxylase tetrahydrate
CN101787048B (en) * 2009-09-23 2011-04-06 北京京卫信康医药科技发展有限公司 Preparation method of cocarboxylase tetrahydrate
CN103351407A (en) * 2012-07-23 2013-10-16 四川海思科制药有限公司 Novel crystal form of cocarboxylase tetrahydrate
CN113402555A (en) * 2020-03-17 2021-09-17 上海医药工业研究院 Preparation method of cocarboxylase and tetrahydrate or salt thereof
CN113402555B (en) * 2020-03-17 2022-12-30 上海医药工业研究院 Preparation method of cocarboxylase and tetrahydrate or salt thereof

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