GB747271A - Oxytetracycline diacetate - Google Patents

Oxytetracycline diacetate

Info

Publication number
GB747271A
GB747271A GB25712/53A GB2571253A GB747271A GB 747271 A GB747271 A GB 747271A GB 25712/53 A GB25712/53 A GB 25712/53A GB 2571253 A GB2571253 A GB 2571253A GB 747271 A GB747271 A GB 747271A
Authority
GB
United Kingdom
Prior art keywords
oxytetracycline
diacetate
acetic anhydride
comptroller
pentane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25712/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Publication of GB747271A publication Critical patent/GB747271A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Oxytetracycline diacetate is prepared by reacting anhydrous or hydrated amphoteric oxytetracycline with acetic anhydride at a temperature not greater than 35 DEG C. A temperature of 0 DEG to 35 DEG C. and especially 15 DEG to 30 DEG C., may be used in conjunction with a reaction time of 1 to 3 weeks. An inert organic solvent may be present in quantities of up to 25 per cent of the acetic anhydride. The acetate is soluble in acetic acid, acetic anhydride, dioxane and acetone but insoluble in ether, water and hydrocarbons such as pentane. It is precipitated from solution by the addition of ether or pentane. It may be crystallized from methanol, ethanol, acetone or toluene. It has high stability in pharmaceutical preparations (see Group VI). Reference has been directed by the Comptroller to Specification 684,417.ALSO:Oxytetracycline diacetate (see Group IV(b)) is more stable towards light and air than oxytetracycline per se, and may be injected or taken orally. Aqueous solutions of pH 8,5 and solutions in propylene glycol may be used for injection. Reference has been directed by the Comptroller to Specification 684,417, [Group IV(b)].
GB25712/53A 1952-09-19 1953-09-17 Oxytetracycline diacetate Expired GB747271A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US747271XA 1952-09-19 1952-09-19

Publications (1)

Publication Number Publication Date
GB747271A true GB747271A (en) 1956-03-28

Family

ID=22121300

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25712/53A Expired GB747271A (en) 1952-09-19 1953-09-17 Oxytetracycline diacetate

Country Status (1)

Country Link
GB (1) GB747271A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997471A (en) * 1958-08-18 1961-08-22 Bristol Myers Co Tetracycline derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997471A (en) * 1958-08-18 1961-08-22 Bristol Myers Co Tetracycline derivatives

Similar Documents

Publication Publication Date Title
GB717708A (en) Improvements in photomechanical resist compositions
ES438946A2 (en) Vincaminic acid esters
GB859510A (en) Stabilized acrylonitrile polymers
GB747271A (en) Oxytetracycline diacetate
GB717712A (en) Improvements in photomechanical resist compositions
GB948307A (en) Preparation of quinacridone pigments
JPS5225710A (en) Process for preparation of isopropyl acetate
ES467216A1 (en) Manufacture of propylene oxide
AU154243B2 (en) Improvements in process for recovering acetic acid and methanol from mixture of methyl acetate, acetic acid, methanol and water
SE7413246L (en)
ES211030A1 (en) A new amine salt of penicillin g
GB739139A (en) Manufacture of 17-hydroxy-20-ketosteroids
GB1229562A (en)
GB669416A (en) Method of producing salts of penicillin
GB706228A (en) Organic acid esters of cellulose
GB578067A (en) Improvements in or relating to cellulose derivatives
NL85384C (en)
GB720477A (en) Improvements in or relating to anti-virus agents, and the preparation thereof
GB673558A (en) Production of a difficultly soluble salt of benzylpenicillin with an organic base
GB719144A (en) The preparation of methionine from ª‡-amino-ª†-methylthiobutyronitrile
GB748470A (en) A process for the manufacture of iso-ergosterone
GB568113A (en) Process of making methylene-bis-4-hydroxycoumarin
ES428016A1 (en) A procedure to prepare new amino acids. (Machine-translation by Google Translate, not legally binding)
GB1058917A (en) Monohydrate of the equimolecular complex of ascorbic acid and pyridoxine base, and process for its preparation
ES382202A1 (en) A procedure for preparing substitute fenoxy-carboxylic acids derivatives. (Machine-translation by Google Translate, not legally binding)