GB569157A - Sulphanilamide derivatives - Google Patents
Sulphanilamide derivativesInfo
- Publication number
- GB569157A GB569157A GB963343A GB963343A GB569157A GB 569157 A GB569157 A GB 569157A GB 963343 A GB963343 A GB 963343A GB 963343 A GB963343 A GB 963343A GB 569157 A GB569157 A GB 569157A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acylamino
- amino
- acetals
- nitro
- acetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
2-(p-Amino-, p-acylamino-, and p-nitro)-sulphonamido-4-methyl pyrimidines are prepared by reacting a p-amino-, p-acylamino-, or a p-nitrobenzenesulphonyl-guanidine with an acetal of b -alkoxycrotonaldehyde. The reaction is carried out by heating the ingredients either alone or in the presence of a solvent such as acetic acid or a high-boiling aliphatic alcohol. As acetals there may be used the diethyl or the dimethyl acetal of b -ethoxy-crotonaldehyde, or the acetals of b -methoxy-, or b -propyloxycrotonaldehyde. The nitro and acylamino compounds may be converted by reduction or hydrolysis respectively into the free amino compound. In an example, b -ethoxycrotonaldehyde is reacted with p-aminobenzenesulphonylguanidine in an amyl alcohol-glacial acetic acid mixture. The ethyl alcohol which is produced is evaporated, the residue extracted with aqueous caustic soda and the crude 2-p-aminobenzenesulphonamido - 4 - methylpyrimidine precipitated by the addition of acid. It is purified by recrystallisation. Specification 552,887 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB963343A GB569157A (en) | 1943-06-16 | 1943-06-16 | Sulphanilamide derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB963343A GB569157A (en) | 1943-06-16 | 1943-06-16 | Sulphanilamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB569157A true GB569157A (en) | 1945-05-10 |
Family
ID=9875754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB963343A Expired GB569157A (en) | 1943-06-16 | 1943-06-16 | Sulphanilamide derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB569157A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2891949A (en) * | 1956-05-10 | 1959-06-23 | American Cyanamid Co | Sulfapyrimidines and methods of preparing the same |
-
1943
- 1943-06-16 GB GB963343A patent/GB569157A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2891949A (en) * | 1956-05-10 | 1959-06-23 | American Cyanamid Co | Sulfapyrimidines and methods of preparing the same |
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