GB552036A - Process for the manufacture of sodium-d-pantothenate in crystalline form - Google Patents
Process for the manufacture of sodium-d-pantothenate in crystalline formInfo
- Publication number
- GB552036A GB552036A GB13918/41A GB1391841A GB552036A GB 552036 A GB552036 A GB 552036A GB 13918/41 A GB13918/41 A GB 13918/41A GB 1391841 A GB1391841 A GB 1391841A GB 552036 A GB552036 A GB 552036A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sodium
- pantothenate
- butyrolactone
- alanine
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
Abstract
552,036. Pantothenic acid. HOFFMANN-LA ROCHE & CO. AKT.-GES., F. Oct. 29, 1941, No. 13918. Convention date, Jan. 17. Sample furnished. [Class 2 (iii)] Sodium-d-pantothenate is prepared in crystalline form by a process which comprises condensing #-alanine with d-(-)-α-hydroxy-##- dimethyl-y-butyrolactone in the presence of the equivalent molecular quantity of a solution of sodium in alcohol, and then slowly adding at a low temperature a solvent such as ether in which sodium-d-pantothenate is insoluble. In an example #-alanine is dissolved with gentle heating in sodium methylate solution and d(-)-α-hydroxy-##-dimethyl-y-butyrolactone is added at 30‹C. On careful addition of ether, the sodium-d-pantothenate crystallizes out. A sample has been furnished under Sect. 2 (5) of crystalline sodium d-pantothenate prepared by adding #-alanine to a solution of sodium in ethyl alcohol, followed by d(-)-α- hydroxY-##-dimethyl-γ-butyrolactone and then after 2 days by the slow addition of ether. Specifications 535,988, 551,883, 552,581 and 552,641, are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH552036X | 1941-01-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB552036A true GB552036A (en) | 1943-03-19 |
Family
ID=4519702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB13918/41A Expired GB552036A (en) | 1941-01-17 | 1941-10-29 | Process for the manufacture of sodium-d-pantothenate in crystalline form |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB552036A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2496363A (en) * | 1948-08-27 | 1950-02-07 | Merck & Co Inc | Process for preparing certain pantothenic acid salts |
CN104761463A (en) * | 2015-03-12 | 2015-07-08 | 成都樵枫科技发展有限公司 | D-sodium pantothenate crystal, preparation method and application thereof |
CN109280015A (en) * | 2018-08-17 | 2019-01-29 | 无锡凯夫制药有限公司 | A kind of synthesis of D-VB5 sodium and chiral separation method |
-
1941
- 1941-10-29 GB GB13918/41A patent/GB552036A/en not_active Expired
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2496363A (en) * | 1948-08-27 | 1950-02-07 | Merck & Co Inc | Process for preparing certain pantothenic acid salts |
CN104761463A (en) * | 2015-03-12 | 2015-07-08 | 成都樵枫科技发展有限公司 | D-sodium pantothenate crystal, preparation method and application thereof |
CN104761463B (en) * | 2015-03-12 | 2017-03-01 | 成都樵枫科技发展有限公司 | D pantothenic acid sodium crystal and its production and use |
CN109280015A (en) * | 2018-08-17 | 2019-01-29 | 无锡凯夫制药有限公司 | A kind of synthesis of D-VB5 sodium and chiral separation method |
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