ES393423A1 - Omega - homo - prostaglandin e1 heptyl ester and production thereof - Google Patents

Omega - homo - prostaglandin e1 heptyl ester and production thereof

Info

Publication number
ES393423A1
ES393423A1 ES393423A ES393423A ES393423A1 ES 393423 A1 ES393423 A1 ES 393423A1 ES 393423 A ES393423 A ES 393423A ES 393423 A ES393423 A ES 393423A ES 393423 A1 ES393423 A1 ES 393423A1
Authority
ES
Spain
Prior art keywords
homo
prostaglandin
omega
production
heptyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES393423A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of ES393423A1 publication Critical patent/ES393423A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Abstract

A method of preparing ω -homo-proataglandin-E1 heptyl ester of the formula: ** (See formula) ** which comprises subjecting 9-oxo-11α, 15α-ditetrahydropyraniloxy- ω -homo-13trans-prostenoic acid of the formula: ** (See formula) ** to mild hydrolysis at 35-40ºC for 2-8 hours and to heptyl esterification with diaxoheptane at or below room temperature, in any order. (Machine-translation by Google Translate, not legally binding)
ES393423A 1970-07-21 1971-07-19 Omega - homo - prostaglandin e1 heptyl ester and production thereof Expired ES393423A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP45063694A JPS4927577B1 (en) 1970-07-21 1970-07-21

Publications (1)

Publication Number Publication Date
ES393423A1 true ES393423A1 (en) 1974-10-01

Family

ID=13236724

Family Applications (1)

Application Number Title Priority Date Filing Date
ES393423A Expired ES393423A1 (en) 1970-07-21 1971-07-19 Omega - homo - prostaglandin e1 heptyl ester and production thereof

Country Status (14)

Country Link
JP (1) JPS4927577B1 (en)
AR (1) AR193707A1 (en)
BE (1) BE770187A (en)
CH (1) CH560177A5 (en)
DE (1) DE2136136A1 (en)
DK (1) DK128530B (en)
ES (1) ES393423A1 (en)
FR (1) FR2100937B1 (en)
GB (1) GB1362955A (en)
HU (1) HU162630B (en)
NL (1) NL7109987A (en)
NO (1) NO132537C (en)
SE (1) SE377112B (en)
SU (1) SU403157A3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163108A (en) * 1967-02-16 1979-07-31 Lever Brothers Company Prostaglandins
DE2317019A1 (en) * 1972-04-27 1973-11-08 Upjohn Co NEW 4,5 DIDEHYDRO PROSTAGLANDIN

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL32553A0 (en) * 1968-07-29 1969-09-25 Upjohn Co Prostaglandins and analogs thereof

Also Published As

Publication number Publication date
NL7109987A (en) 1972-01-25
JPS4927577B1 (en) 1974-07-18
NO132537B (en) 1975-08-18
SE377112B (en) 1975-06-23
AR193707A1 (en) 1973-05-22
DK128530B (en) 1974-05-20
FR2100937B1 (en) 1975-08-01
SU403157A3 (en) 1973-10-19
CH560177A5 (en) 1975-03-27
NO132537C (en) 1975-11-26
GB1362955A (en) 1974-08-07
FR2100937A1 (en) 1972-03-24
DE2136136A1 (en) 1972-01-27
HU162630B (en) 1973-03-28
BE770187A (en) 1971-12-01

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