GB277774A - Manufacture of solutions of bismuth salts of aryl-arsinic acids - Google Patents
Manufacture of solutions of bismuth salts of aryl-arsinic acidsInfo
- Publication number
- GB277774A GB277774A GB1790326A GB1790326A GB277774A GB 277774 A GB277774 A GB 277774A GB 1790326 A GB1790326 A GB 1790326A GB 1790326 A GB1790326 A GB 1790326A GB 277774 A GB277774 A GB 277774A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bismuth
- piperazine
- solution
- acid
- acetylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
277,774. Haythornthwaite, A., and May & Baker, Ltd. July 16, 1926. Medicines for internal use.-Stable solutions of bismuth salts of arylarsinic acids are prepared by the addition of a base to a suspension of the salt to render it soluble and of a salt of an aliphatic hydroxypolybasic acid with a base to stabilize the solution. The two bases, which may be the same or different, comprise ammonia or a strongly-basic substituted ammonia, another strong base such as piperazine, or a caustic alkali; organic acids specified are citric and tartaric acids. The bismuth salt may be prepared in situ in the solution in which it is dissolved. Neutrality of the final solution may be effected by adding a weak acid such as acetic acid. According to the examples, (1) bismuth 3-acetylamino-4-oxyphenylarsinate is mixed with sodium potassium tartrate and either piperazine, sodium hydroxide or ammonia in water, and the solution neutralized with acetic acid; (2) piperazine is added to a suspension of 3-acetylamino-4-oxyphenylarsinic acid, sodium potassium tartrate and sodium bismuthyl tartrate added, and the solution neutralized with acetic acid; (3) a solution of piperazine and sodium potassium tartrate is added to bismuth N-phenylglycinamide-p-arsinate or bismuth p-aminophenylarsinate; (4) a mixture of bismuth 3-acetylamino- 4-oxyphenylarsinate, piperazine and tartaric acid is taken up with water. Specifications 258,641, and 266,820, [Class 1 (iii), Oxides &c., Metallic], are referred to. According to the Provisional Specification, stabilization may be effected by the addition of a polyhydroxyalcohol such as glucose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1790326A GB277774A (en) | 1926-07-16 | 1926-07-16 | Manufacture of solutions of bismuth salts of aryl-arsinic acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1790326A GB277774A (en) | 1926-07-16 | 1926-07-16 | Manufacture of solutions of bismuth salts of aryl-arsinic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB277774A true GB277774A (en) | 1927-09-29 |
Family
ID=10103262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1790326A Expired GB277774A (en) | 1926-07-16 | 1926-07-16 | Manufacture of solutions of bismuth salts of aryl-arsinic acids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB277774A (en) |
-
1926
- 1926-07-16 GB GB1790326A patent/GB277774A/en not_active Expired
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