GB277774A - Manufacture of solutions of bismuth salts of aryl-arsinic acids - Google Patents

Manufacture of solutions of bismuth salts of aryl-arsinic acids

Info

Publication number
GB277774A
GB277774A GB1790326A GB1790326A GB277774A GB 277774 A GB277774 A GB 277774A GB 1790326 A GB1790326 A GB 1790326A GB 1790326 A GB1790326 A GB 1790326A GB 277774 A GB277774 A GB 277774A
Authority
GB
United Kingdom
Prior art keywords
bismuth
piperazine
solution
acid
acetylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1790326A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALAN HAYTHORNTHWAITE
May and Baker Ltd
Original Assignee
ALAN HAYTHORNTHWAITE
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALAN HAYTHORNTHWAITE, May and Baker Ltd filed Critical ALAN HAYTHORNTHWAITE
Priority to GB1790326A priority Critical patent/GB277774A/en
Publication of GB277774A publication Critical patent/GB277774A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

277,774. Haythornthwaite, A., and May & Baker, Ltd. July 16, 1926. Medicines for internal use.-Stable solutions of bismuth salts of arylarsinic acids are prepared by the addition of a base to a suspension of the salt to render it soluble and of a salt of an aliphatic hydroxypolybasic acid with a base to stabilize the solution. The two bases, which may be the same or different, comprise ammonia or a strongly-basic substituted ammonia, another strong base such as piperazine, or a caustic alkali; organic acids specified are citric and tartaric acids. The bismuth salt may be prepared in situ in the solution in which it is dissolved. Neutrality of the final solution may be effected by adding a weak acid such as acetic acid. According to the examples, (1) bismuth 3-acetylamino-4-oxyphenylarsinate is mixed with sodium potassium tartrate and either piperazine, sodium hydroxide or ammonia in water, and the solution neutralized with acetic acid; (2) piperazine is added to a suspension of 3-acetylamino-4-oxyphenylarsinic acid, sodium potassium tartrate and sodium bismuthyl tartrate added, and the solution neutralized with acetic acid; (3) a solution of piperazine and sodium potassium tartrate is added to bismuth N-phenylglycinamide-p-arsinate or bismuth p-aminophenylarsinate; (4) a mixture of bismuth 3-acetylamino- 4-oxyphenylarsinate, piperazine and tartaric acid is taken up with water. Specifications 258,641, and 266,820, [Class 1 (iii), Oxides &c., Metallic], are referred to. According to the Provisional Specification, stabilization may be effected by the addition of a polyhydroxyalcohol such as glucose.
GB1790326A 1926-07-16 1926-07-16 Manufacture of solutions of bismuth salts of aryl-arsinic acids Expired GB277774A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1790326A GB277774A (en) 1926-07-16 1926-07-16 Manufacture of solutions of bismuth salts of aryl-arsinic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1790326A GB277774A (en) 1926-07-16 1926-07-16 Manufacture of solutions of bismuth salts of aryl-arsinic acids

Publications (1)

Publication Number Publication Date
GB277774A true GB277774A (en) 1927-09-29

Family

ID=10103262

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1790326A Expired GB277774A (en) 1926-07-16 1926-07-16 Manufacture of solutions of bismuth salts of aryl-arsinic acids

Country Status (1)

Country Link
GB (1) GB277774A (en)

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