GB2356348B - Potentiation of the analgesic effect of Buprenorphine - Google Patents

Potentiation of the analgesic effect of Buprenorphine

Info

Publication number
GB2356348B
GB2356348B GB0028088A GB0028088A GB2356348B GB 2356348 B GB2356348 B GB 2356348B GB 0028088 A GB0028088 A GB 0028088A GB 0028088 A GB0028088 A GB 0028088A GB 2356348 B GB2356348 B GB 2356348B
Authority
GB
United Kingdom
Prior art keywords
buprenorphine
potentiation
analgesic effect
analgesic
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0028088A
Other languages
English (en)
Other versions
GB2356348A (en
GB0028088D0 (en
Inventor
Christopher Bourne Chapleo
Keith Mccormack
Nicolas Calvert Varey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reckitt Benckiser Healthcare UK Ltd
Original Assignee
Reckitt and Colman Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9927359.1A external-priority patent/GB9927359D0/en
Application filed by Reckitt and Colman Products Ltd filed Critical Reckitt and Colman Products Ltd
Publication of GB0028088D0 publication Critical patent/GB0028088D0/en
Publication of GB2356348A publication Critical patent/GB2356348A/en
Application granted granted Critical
Publication of GB2356348B publication Critical patent/GB2356348B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
GB0028088A 1999-11-19 2000-11-17 Potentiation of the analgesic effect of Buprenorphine Expired - Fee Related GB2356348B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9927359.1A GB9927359D0 (en) 1999-11-19 1999-11-19 Improvements in or relating to organic compositions
US17620800P 2000-01-14 2000-01-14

Publications (3)

Publication Number Publication Date
GB0028088D0 GB0028088D0 (en) 2001-01-03
GB2356348A GB2356348A (en) 2001-05-23
GB2356348B true GB2356348B (en) 2002-02-06

Family

ID=26316086

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0028088A Expired - Fee Related GB2356348B (en) 1999-11-19 2000-11-17 Potentiation of the analgesic effect of Buprenorphine

Country Status (30)

Country Link
US (4) US6995169B2 (OSRAM)
EP (1) EP1242087B1 (OSRAM)
JP (1) JP4745576B2 (OSRAM)
KR (1) KR100726699B1 (OSRAM)
CN (1) CN100431543C (OSRAM)
AR (1) AR031682A1 (OSRAM)
AT (1) ATE262335T1 (OSRAM)
AU (1) AU777259B2 (OSRAM)
BR (1) BR0015580A (OSRAM)
CA (1) CA2392013C (OSRAM)
CO (1) CO5261517A1 (OSRAM)
CZ (1) CZ303160B6 (OSRAM)
DE (1) DE60009346T2 (OSRAM)
DK (1) DK1242087T3 (OSRAM)
ES (1) ES2214334T3 (OSRAM)
GB (1) GB2356348B (OSRAM)
HU (1) HU229565B1 (OSRAM)
IL (2) IL149580A0 (OSRAM)
MX (1) MXPA02004978A (OSRAM)
NO (1) NO321965B1 (OSRAM)
NZ (1) NZ519023A (OSRAM)
PL (1) PL199727B1 (OSRAM)
PT (1) PT1242087E (OSRAM)
RO (1) RO121174B1 (OSRAM)
RU (1) RU2255737C2 (OSRAM)
SI (1) SI21025B (OSRAM)
SK (1) SK286888B6 (OSRAM)
TR (1) TR200400653T4 (OSRAM)
TW (1) TW550070B (OSRAM)
WO (1) WO2001035942A2 (OSRAM)

Families Citing this family (37)

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AR031682A1 (es) * 1999-11-19 2003-10-01 Reckitt Benckiser Helthcare Uk Composiciones farmaceuticas
US20150031718A1 (en) * 2001-08-06 2015-01-29 Purdue Pharma L.P. Pharmaceutical Formulation Containing Opioid Agonist, Opioid Antagonist and Gelling Agent
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
US7666876B2 (en) * 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
MXPA05011557A (es) 2003-04-29 2006-03-09 Orexigen Therapeutics Inc Composiciones para afectar perdida de peso.
CA2569958C (en) 2004-06-12 2016-03-22 Jane C. Hirsh Abuse-deterrent drug formulations
JP5180092B2 (ja) 2005-11-22 2013-04-10 オレキシジェン・セラピューティクス・インコーポレーテッド インスリン感受性を増すための組成物および方法
WO2007089318A2 (en) * 2005-11-23 2007-08-09 Orexigen Therapeutics, Inc. Compositions and methods for reducing food cravings
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
EP1897543A1 (en) 2006-08-30 2008-03-12 Euro-Celtique S.A. Buprenorphine- wafer for drug substitution therapy
CA2674915C (en) * 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
US8093261B2 (en) 2006-10-24 2012-01-10 The Johns Hopkins University Rapid release mini-tablets provide analgesia in laboratory animals
MX343867B (es) * 2006-11-09 2016-11-25 Orexigen Therapeutics Inc Paquete de dosificacion unitaria y metodos para administrar medicaciones de perdida de peso.
US20080199407A1 (en) 2007-02-15 2008-08-21 Slater Kenneth C Drug Detoxification Protocol Using Microdosing
GB2447016A (en) * 2007-03-01 2008-09-03 Reckitt Benckiser Healthcare Buprenorphine/naloxone compositions
GB2447013A (en) * 2007-03-01 2008-09-03 Reckitt Benckiser Healthcare Analgesic composition containing buprenorphone and nalmefene
GB2447015A (en) * 2007-03-01 2008-09-03 Reckitt Benckiser Healthcare Analgesic composition comprising a specific ratio of buprenorphine and naltrexone
GB2447014A (en) * 2007-03-01 2008-09-03 Reckitt Benckiser Healthcare Analgesic composition comprising a specific ratio of buprenorphine and naltrexone
MX2010002409A (es) * 2007-09-03 2010-05-19 Nanotherapeutics Inc Composiciones y metodos para la distribucion de farmacos escasamente solubles.
US20090082383A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched buprenorphine
MX2010012909A (es) 2008-05-30 2011-02-25 Orexigen Therapeutics Inc Metodos para tratamiento de condiciones de grasa visceral.
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
EP2523557B1 (en) 2010-01-11 2019-09-25 Nalpropion Pharmaceuticals, Inc. Methods of providing weight loss therapy in patients with major depression
CN104873455B (zh) 2010-12-22 2023-09-12 普渡制药公司 包覆的抗篡改控制释放剂型
PH12013501345A1 (en) 2010-12-23 2022-10-24 Purdue Pharma Lp Tamper resistant solid oral dosage forms
EP2915525B1 (en) 2011-09-19 2021-08-11 Orexo AB Sublingual abuse-resistant tablets comprising buprenorphine and naloxone
PL4104824T3 (pl) 2012-06-06 2025-11-12 Nalpropion Pharmaceuticals Llc Kompozycja do zastosowania w sposobie leczenia nadwagi i otyłości u pacjentów z wysokim ryzykiem sercowo-naczyniowym
CN104955483A (zh) 2013-01-30 2015-09-30 法莫斯医疗公司 用低剂量药剂治疗抑郁症和其它疾病
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
DK3043777T3 (da) 2013-09-10 2020-07-20 Fresh Cut Dev Llc Sublingual buprenorphinspray
US8969371B1 (en) 2013-12-06 2015-03-03 Orexigen Therapeutics, Inc. Compositions and methods for weight loss in at risk patient populations
SG10201809280PA (en) * 2014-04-22 2018-11-29 Otsuka Pharma Co Ltd Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders
WO2017222575A1 (en) 2016-06-23 2017-12-28 Collegium Pharmaceutical, Inc. Process of making more stable abuse-deterrent oral formulations
WO2021158957A1 (en) * 2020-02-05 2021-08-12 Summit Biosciences Inc. Drug products for intranasal administration and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2150832A (en) * 1983-12-06 1985-07-10 Reckitt & Colmann Prod Ltd Analgesic compositions containing buprenorphine
GB2167663A (en) * 1984-11-30 1986-06-04 Reckitt & Colmann Prod Ltd Analgesics containing buprenorphine and naltrexone
GB2213058A (en) * 1987-12-03 1989-08-09 Reckitt & Colmann Prod Ltd Opiate addiction composition containing buprenorphine and naltrexone

Family Cites Families (9)

* Cited by examiner, † Cited by third party
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GB8430109D0 (en) 1984-11-29 1985-01-09 Gkn Technology Ltd Securing components
GB8728294D0 (en) * 1987-12-03 1988-01-06 Reckitt & Colmann Prod Ltd Treatment compositions
US5512578A (en) * 1992-09-21 1996-04-30 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists
US20010006967A1 (en) * 1992-09-21 2001-07-05 Stanley M. Crain Method of simultaneously enhancing analgesic potency and attenuating adverse side effects caused by tramadol and other bimodally-acting opioid agonists
US5472943A (en) * 1992-09-21 1995-12-05 Albert Einstein College Of Medicine Of Yeshiva University, Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists
US5580876A (en) * 1992-09-21 1996-12-03 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
RU2077326C1 (ru) * 1992-12-29 1997-04-20 Ярыгин Владимир Никитич Препарат для анальгезии
AR031682A1 (es) * 1999-11-19 2003-10-01 Reckitt Benckiser Helthcare Uk Composiciones farmaceuticas
JP2004501094A (ja) * 2000-05-05 2004-01-15 ペイン・セラピューティクス・インコーポレイテッド オピオイドアゴニストの効力を増強するか、またはオピオイドアゴニストの有害な副作用を減弱するための新規な組成物および方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2150832A (en) * 1983-12-06 1985-07-10 Reckitt & Colmann Prod Ltd Analgesic compositions containing buprenorphine
GB2167663A (en) * 1984-11-30 1986-06-04 Reckitt & Colmann Prod Ltd Analgesics containing buprenorphine and naltrexone
GB2213058A (en) * 1987-12-03 1989-08-09 Reckitt & Colmann Prod Ltd Opiate addiction composition containing buprenorphine and naltrexone

Also Published As

Publication number Publication date
CN100431543C (zh) 2008-11-12
PL199727B1 (pl) 2008-10-31
EP1242087B1 (en) 2004-03-24
RU2255737C2 (ru) 2005-07-10
ATE262335T1 (de) 2004-04-15
WO2001035942A9 (en) 2002-11-28
WO2001035942A2 (en) 2001-05-25
JP2003514013A (ja) 2003-04-15
US20060069113A1 (en) 2006-03-30
KR20020058022A (ko) 2002-07-12
BR0015580A (pt) 2002-07-09
IL149580A (en) 2007-05-15
GB2356348A (en) 2001-05-23
ES2214334T3 (es) 2004-09-16
US20030004178A1 (en) 2003-01-02
SI21025A (sl) 2003-04-30
SI21025B (sl) 2008-04-30
CN1413110A (zh) 2003-04-23
RU2002116361A (ru) 2004-01-27
NZ519023A (en) 2004-11-26
DK1242087T3 (da) 2004-07-19
NO20022330L (no) 2002-07-04
JP4745576B2 (ja) 2011-08-10
RO121174B1 (ro) 2007-01-30
US6995169B2 (en) 2006-02-07
SK8762002A3 (en) 2002-12-03
EP1242087A2 (en) 2002-09-25
US20060058333A1 (en) 2006-03-16
HU229565B1 (hu) 2014-02-28
DE60009346T2 (de) 2005-02-10
HUP0203588A2 (hu) 2003-03-28
MXPA02004978A (es) 2003-01-28
HUP0203588A3 (en) 2005-01-28
US20060058332A1 (en) 2006-03-16
NO20022330D0 (no) 2002-05-15
CZ303160B6 (cs) 2012-05-09
AR031682A1 (es) 2003-10-01
DE60009346D1 (de) 2004-04-29
WO2001035942A3 (en) 2002-06-13
AU777259B2 (en) 2004-10-07
PT1242087E (pt) 2004-06-30
CA2392013A1 (en) 2001-05-25
NO321965B1 (no) 2006-07-31
SK286888B6 (sk) 2009-07-06
HK1055389A1 (zh) 2004-01-09
IL149580A0 (en) 2002-11-10
PL355330A1 (en) 2004-04-19
TW550070B (en) 2003-09-01
CA2392013C (en) 2009-08-11
CO5261517A1 (es) 2003-03-31
TR200400653T4 (tr) 2004-04-21
AU1529701A (en) 2001-05-30
US7402591B2 (en) 2008-07-22
GB0028088D0 (en) 2001-01-03
KR100726699B1 (ko) 2007-06-13

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)

Free format text: REGISTERED BETWEEN 20120927 AND 20121003

PCNP Patent ceased through non-payment of renewal fee

Effective date: 20151117