GB2239241B - Novel process for the preparation of n-(2-amino-3,5-dibromobenzyl)-trans-4-amino-cyclohexanol - Google Patents

Novel process for the preparation of n-(2-amino-3,5-dibromobenzyl)-trans-4-amino-cyclohexanol

Info

Publication number
GB2239241B
GB2239241B GB9027815A GB9027815A GB2239241B GB 2239241 B GB2239241 B GB 2239241B GB 9027815 A GB9027815 A GB 9027815A GB 9027815 A GB9027815 A GB 9027815A GB 2239241 B GB2239241 B GB 2239241B
Authority
GB
United Kingdom
Prior art keywords
amino
dibromobenzyl
cyclohexanol
trans
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9027815A
Other languages
English (en)
Other versions
GB9027815D0 (en
GB2239241A (en
Inventor
Ildiko Ratz
Pal Benko
Daniel Bozsing
Antal Tungler
Tibor Mathe
Gyoergy Kovanyi
Jozsef Petro
Ilona Sztruhar
Gyoergyi Vereczkey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of GB9027815D0 publication Critical patent/GB9027815D0/en
Publication of GB2239241A publication Critical patent/GB2239241A/en
Application granted granted Critical
Publication of GB2239241B publication Critical patent/GB2239241B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
GB9027815A 1989-12-22 1990-12-21 Novel process for the preparation of n-(2-amino-3,5-dibromobenzyl)-trans-4-amino-cyclohexanol Expired - Fee Related GB2239241B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU896745A HU207834B (en) 1989-12-22 1989-12-22 Process for producing n-/2-amino-3,5-dibromo-benzyl/-trans-4-amino-cyclohexanol

Publications (3)

Publication Number Publication Date
GB9027815D0 GB9027815D0 (en) 1991-02-13
GB2239241A GB2239241A (en) 1991-06-26
GB2239241B true GB2239241B (en) 1993-07-14

Family

ID=10971988

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9027815A Expired - Fee Related GB2239241B (en) 1989-12-22 1990-12-21 Novel process for the preparation of n-(2-amino-3,5-dibromobenzyl)-trans-4-amino-cyclohexanol

Country Status (5)

Country Link
JP (1) JPH04217943A (de)
AT (1) AT400435B (de)
GB (1) GB2239241B (de)
HU (1) HU207834B (de)
IT (1) IT1246049B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102351720B (zh) * 2011-10-21 2013-11-06 南京理工大学 一种简易高效的氨溴素合成方法
CN102964257B (zh) * 2012-11-24 2014-08-06 沈阳新马药业有限公司 一种盐酸氨溴索化合物及其药物组合物
CN109970579A (zh) * 2019-04-22 2019-07-05 浙江海洲制药有限公司 一种制备盐酸氨溴索的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2218647A1 (de) * 1972-04-18 1973-10-25 Thomae Gmbh Dr K Neues verfahren zur herstellung von n-(trans-4-hydroxy-cyclohexyl)-(2-amino3,5-dibrom-benzyl)-amin
EP0130224A1 (de) * 1983-06-29 1985-01-09 LUDWIG HEUMANN & CO GMBH Verfahren zur Herstellung von 2-Amino-3,5-dibrombenzylaminen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2218647A1 (de) * 1972-04-18 1973-10-25 Thomae Gmbh Dr K Neues verfahren zur herstellung von n-(trans-4-hydroxy-cyclohexyl)-(2-amino3,5-dibrom-benzyl)-amin
EP0130224A1 (de) * 1983-06-29 1985-01-09 LUDWIG HEUMANN & CO GMBH Verfahren zur Herstellung von 2-Amino-3,5-dibrombenzylaminen

Also Published As

Publication number Publication date
HU207834B (en) 1993-06-28
ATA261990A (de) 1995-05-15
HU896745D0 (en) 1990-03-28
GB9027815D0 (en) 1991-02-13
IT1246049B (it) 1994-11-07
IT9022507A1 (it) 1992-06-21
JPH04217943A (ja) 1992-08-07
HUT58274A (en) 1992-02-28
IT9022507A0 (it) 1990-12-21
GB2239241A (en) 1991-06-26
AT400435B (de) 1995-12-27

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19961221