GB201710838D0 - Bispecific antibodies - Google Patents

Bispecific antibodies

Info

Publication number
GB201710838D0
GB201710838D0 GBGB1710838.2A GB201710838A GB201710838D0 GB 201710838 D0 GB201710838 D0 GB 201710838D0 GB 201710838 A GB201710838 A GB 201710838A GB 201710838 D0 GB201710838 D0 GB 201710838D0
Authority
GB
United Kingdom
Prior art keywords
bispecific antibodies
bispecific
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1710838.2A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCL Business Ltd
Original Assignee
UCL Business Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCL Business Ltd filed Critical UCL Business Ltd
Priority to GBGB1710838.2A priority Critical patent/GB201710838D0/en
Publication of GB201710838D0 publication Critical patent/GB201710838D0/en
Priority to JP2019572470A priority patent/JP2020529839A/ja
Priority to MX2019015349A priority patent/MX2019015349A/es
Priority to CA3068200A priority patent/CA3068200A1/en
Priority to AU2018295479A priority patent/AU2018295479A1/en
Priority to ES18742577T priority patent/ES2906361T3/es
Priority to CN201880045360.XA priority patent/CN110891972B/zh
Priority to DK18742577.2T priority patent/DK3645565T3/da
Priority to EP21206411.7A priority patent/EP3985026A1/en
Priority to PCT/GB2018/051916 priority patent/WO2019008379A1/en
Priority to US16/628,404 priority patent/US11306142B2/en
Priority to EP18742577.2A priority patent/EP3645565B1/en
Priority to US17/698,657 priority patent/US20220204621A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
GBGB1710838.2A 2017-07-05 2017-07-05 Bispecific antibodies Ceased GB201710838D0 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GBGB1710838.2A GB201710838D0 (en) 2017-07-05 2017-07-05 Bispecific antibodies
EP18742577.2A EP3645565B1 (en) 2017-07-05 2018-07-05 Bispecific antibodies to ror1 and cd3
CN201880045360.XA CN110891972B (zh) 2017-07-05 2018-07-05 对ror1和cd3的双特异性抗体
MX2019015349A MX2019015349A (es) 2017-07-05 2018-07-05 Anticuerpos biespecificos para receptor 1 huerfano tipo receptor de tirosina cinasa (ror1) y grupo de diferenciacion 3 (cd3).
CA3068200A CA3068200A1 (en) 2017-07-05 2018-07-05 Bispecific antibodies to ror1 and cd3
AU2018295479A AU2018295479A1 (en) 2017-07-05 2018-07-05 Bispecific antibodies to ROR1 and CD3
ES18742577T ES2906361T3 (es) 2017-07-05 2018-07-05 Anticuerpos biespecíficos para ROR1 y CD3
JP2019572470A JP2020529839A (ja) 2017-07-05 2018-07-05 Ｒｏｒ１及びｃｄ３に対する二重特異性抗体
DK18742577.2T DK3645565T3 (da) 2017-07-05 2018-07-05 Bispecifikke antistoffer mod ROR1 og CD3
EP21206411.7A EP3985026A1 (en) 2017-07-05 2018-07-05 Bispecific antibodies to ror1 and cd3
PCT/GB2018/051916 WO2019008379A1 (en) 2017-07-05 2018-07-05 BISPECIFIC ANTIBODIES DIRECTED AGAINST ROR1 AND CD3
US16/628,404 US11306142B2 (en) 2017-07-05 2018-07-05 Bispecific antibodies to ROR1 and CD3
US17/698,657 US20220204621A1 (en) 2017-07-05 2022-03-18 Bispecific antibodies to ror1 and cd3

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1710838.2A GB201710838D0 (en) 2017-07-05 2017-07-05 Bispecific antibodies

Publications (1)

Publication Number Publication Date
GB201710838D0 true GB201710838D0 (en) 2017-08-16

Family

ID=59592717

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1710838.2A Ceased GB201710838D0 (en) 2017-07-05 2017-07-05 Bispecific antibodies

Country Status (11)

Country Link
US (2) US11306142B2 (https=)
EP (2) EP3985026A1 (https=)
JP (1) JP2020529839A (https=)
CN (1) CN110891972B (https=)
AU (1) AU2018295479A1 (https=)
CA (1) CA3068200A1 (https=)
DK (1) DK3645565T3 (https=)
ES (1) ES2906361T3 (https=)
GB (1) GB201710838D0 (https=)
MX (1) MX2019015349A (https=)
WO (1) WO2019008379A1 (https=)

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GB201710835D0 (en) * 2017-07-05 2017-08-16 Ucl Business Plc ROR1 Antibodies
CN111662382A (zh) * 2019-03-06 2020-09-15 瑞阳(苏州)生物科技有限公司 特异结合cd3的抗体、抗原结合片段和单链抗体可变区片段及其应用
IL322315A (en) 2019-05-14 2025-09-01 Provention Bio Inc Methods and preparations for preventing type 1 diabetes
CN113874399B (zh) * 2019-05-23 2025-07-11 维洛斯生物股份有限公司 抗ror1/抗cd3双特异性结合分子
CN114127110B (zh) * 2019-05-30 2022-07-01 山东博安生物技术股份有限公司 抗cgrp抗体及其应用
KR20220071263A (ko) * 2019-09-30 2022-05-31 하버 바이오메드 (쑤저우) 컴퍼니 리미티드 Cd3을 표적으로 하는 항체, 이중 특이성 항체 및 이의 용도
AU2021287998B2 (en) 2020-06-11 2026-03-12 Benaroya Research Institute At Virginia Mason Methods and compositions for preventing type 1 diabetes
KR20230053602A (ko) * 2020-08-24 2023-04-21 에피맙 바이오테라퓨틱스 (에이치케이) 리미티드 항-ror1 항체 및 관련된 이중특이적 결합 단백질
MX2023009022A (es) * 2021-02-02 2023-10-23 Numab Therapeutics AG Anticuerpos multiespecificos con especificidad para ror1 y cd3.
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
EP4320243A4 (en) * 2021-04-09 2025-03-12 Vivasor, Inc. Oncolytic viruses expressing anti-ror1/anti-cd3 bispecific antibodies
US12565529B2 (en) 2021-05-24 2026-03-03 Provention Bio, Inc. Methods for treating type 1 diabetes
CN118302448A (zh) * 2021-12-28 2024-07-05 江苏恒瑞医药股份有限公司 抗ror1抗体和抗ror1抗体药物偶联物及其医药用途
GB202216284D0 (en) 2022-11-02 2022-12-14 Ucl Business Ltd Self-regulation
TW202434635A (zh) * 2022-11-03 2024-09-01 美商翰森生物有限責任公司 多特異性抗體及其醫藥用途
CN120712345A (zh) * 2022-12-30 2025-09-26 上药生物治疗（香港）有限公司 表达趋化因子受体的细胞及其用途
CN116731178A (zh) * 2023-06-14 2023-09-12 北京大学深圳研究生院 抗人ror1抗体、基因及其应用
WO2025061032A1 (zh) * 2023-09-18 2025-03-27 南京蓬勃生物科技有限公司 靶向人源ror1和cd3的双特异性抗体

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Also Published As

Publication number Publication date
CN110891972B (zh) 2023-05-30
EP3645565B1 (en) 2021-12-15
US11306142B2 (en) 2022-04-19
US20200157218A1 (en) 2020-05-21
WO2019008379A1 (en) 2019-01-10
US20220204621A1 (en) 2022-06-30
JP2020529839A (ja) 2020-10-15
AU2018295479A1 (en) 2020-01-16
ES2906361T3 (es) 2022-04-18
MX2019015349A (es) 2020-07-20
CN110891972A (zh) 2020-03-17
EP3985026A1 (en) 2022-04-20
DK3645565T3 (da) 2022-02-14
CA3068200A1 (en) 2019-01-10
EP3645565A1 (en) 2020-05-06

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