GB201514875D0 - Receptor - Google Patents

Receptor

Info

Publication number
GB201514875D0
GB201514875D0 GBGB1514875.2A GB201514875A GB201514875D0 GB 201514875 D0 GB201514875 D0 GB 201514875D0 GB 201514875 A GB201514875 A GB 201514875A GB 201514875 D0 GB201514875 D0 GB 201514875D0
Authority
GB
United Kingdom
Prior art keywords
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1514875.2A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Autolus Ltd
Original Assignee
Autolus Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Autolus Ltd filed Critical Autolus Ltd
Priority to GBGB1514875.2A priority Critical patent/GB201514875D0/en
Publication of GB201514875D0 publication Critical patent/GB201514875D0/en
Priority to IL270207A priority patent/IL270207B2/en
Priority to SG10201909759U priority patent/SG10201909759UA/en
Priority to CN201911010436.8A priority patent/CN110724200B/zh
Priority to PCT/GB2016/052564 priority patent/WO2017029512A1/en
Priority to EP23216609.0A priority patent/EP4338756A3/en
Priority to KR1020247017118A priority patent/KR20240093884A/ko
Priority to CN201680046834.3A priority patent/CN108350047A/zh
Priority to MX2019013204A priority patent/MX421045B/es
Priority to JP2018509549A priority patent/JP2018523485A/ja
Priority to EP18189793.5A priority patent/EP3438123B1/en
Priority to US15/753,486 priority patent/US10800854B2/en
Priority to CA2995785A priority patent/CA2995785A1/en
Priority to EP16756758.5A priority patent/EP3337814A1/en
Priority to HK18111554.5A priority patent/HK1252161A1/zh
Priority to AU2016308618A priority patent/AU2016308618B2/en
Priority to ES18189793T priority patent/ES3076016T3/es
Priority to BR112018003308-1A priority patent/BR112018003308A2/pt
Priority to RU2018109350A priority patent/RU2018109350A/ru
Priority to CA3091907A priority patent/CA3091907C/en
Priority to MX2018002042A priority patent/MX2018002042A/es
Priority to KR1020187007751A priority patent/KR102669749B1/ko
Priority to NZ739942A priority patent/NZ739942B2/en
Priority to IL257234A priority patent/IL257234A/en
Priority to CL2018000415A priority patent/CL2018000415A1/es
Priority to US16/113,224 priority patent/US10800855B2/en
Priority to CL2019001107A priority patent/CL2019001107A1/es
Priority to JP2019113625A priority patent/JP6979423B2/ja
Priority to ZA2019/04156A priority patent/ZA201904156B/en
Priority to US16/999,012 priority patent/US11479614B2/en
Priority to US16/998,756 priority patent/US11479613B2/en
Priority to JP2020199336A priority patent/JP7603426B2/ja
Priority to US17/815,110 priority patent/US12234295B2/en
Priority to JP2022178045A priority patent/JP2022190153A/ja
Priority to US19/033,252 priority patent/US20250333538A1/en
Priority to JP2025047074A priority patent/JP2025089403A/ja
Priority to JP2025047075A priority patent/JP2025089404A/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001116—Receptors for cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00113—Growth factors
    • A61K39/001135—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00118—Cancer antigens from embryonic or fetal origin
    • A61K39/001182—Carcinoembryonic antigen [CEA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A61K39/001194—Prostate specific antigen [PSA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4274—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
    • A61K40/4275—Prostate specific antigen [PSA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4274—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; Prostatic acid phosphatase [PAP]; Prostate-specific G-protein-coupled receptor [PSGR]
    • A61K40/4276—Prostate specific membrane antigen [PSMA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
GBGB1514875.2A 2015-08-20 2015-08-20 Receptor Ceased GB201514875D0 (en)

Priority Applications (37)

Application Number Priority Date Filing Date Title
GBGB1514875.2A GB201514875D0 (en) 2015-08-20 2015-08-20 Receptor
NZ739942A NZ739942B2 (en) 2015-08-20 2016-08-19 Chimeric cytokine receptor
RU2018109350A RU2018109350A (ru) 2015-08-20 2016-08-19 Химерный цитокиновый рецептор
CA3091907A CA3091907C (en) 2015-08-20 2016-08-19 Cell comprising a chimeric antigen receptor (car) and a constitutively active cytokine-signalling chimeric transmembrane protein
CN201911010436.8A CN110724200B (zh) 2015-08-20 2016-08-19 嵌合细胞因子受体
PCT/GB2016/052564 WO2017029512A1 (en) 2015-08-20 2016-08-19 Chimeric cytokine receptor
EP23216609.0A EP4338756A3 (en) 2015-08-20 2016-08-19 Chimeric cytokine receptor
KR1020187007751A KR102669749B1 (ko) 2015-08-20 2016-08-19 키메라 사이토카인 수용체
CN201680046834.3A CN108350047A (zh) 2015-08-20 2016-08-19 嵌合细胞因子受体
MX2019013204A MX421045B (es) 2015-08-20 2016-08-19 Proteína transmembrana quimérica de señalización de citoquinas constitutivamente activa
JP2018509549A JP2018523485A (ja) 2015-08-20 2016-08-19 キメラサイトカイン受容体
EP18189793.5A EP3438123B1 (en) 2015-08-20 2016-08-19 Chimeric cytokine receptor
US15/753,486 US10800854B2 (en) 2015-08-20 2016-08-19 Chimeric cytokine receptors and encoding nucleic acids
CA2995785A CA2995785A1 (en) 2015-08-20 2016-08-19 Chimeric cytokine receptor
EP16756758.5A EP3337814A1 (en) 2015-08-20 2016-08-19 Chimeric cytokine receptor
HK18111554.5A HK1252161A1 (zh) 2015-08-20 2016-08-19 嵌合细胞因子受体
AU2016308618A AU2016308618B2 (en) 2015-08-20 2016-08-19 Chimeric cytokine receptor
ES18189793T ES3076016T3 (en) 2015-08-20 2016-08-19 Chimeric cytokine receptor
BR112018003308-1A BR112018003308A2 (pt) 2015-08-20 2016-08-19 receptor quimérico de citocina
IL270207A IL270207B2 (en) 2015-08-20 2016-08-19 Chimeric cytokine receptor
MX2018002042A MX2018002042A (es) 2015-08-20 2016-08-19 Receptor.
SG10201909759U SG10201909759UA (en) 2015-08-20 2016-08-19 Chimeric Cytokine Receptor
KR1020247017118A KR20240093884A (ko) 2015-08-20 2016-08-19 키메라 사이토카인 수용체
IL257234A IL257234A (en) 2015-08-20 2018-01-30 Chimeric cytokine receptor
CL2018000415A CL2018000415A1 (es) 2015-08-20 2018-02-15 Receptor quimerica de citocinas.
US16/113,224 US10800855B2 (en) 2015-08-20 2018-08-27 Chimeric cytokine receptors and encoding nucleic acids
CL2019001107A CL2019001107A1 (es) 2015-08-20 2019-04-23 Receptor quimérico de citocinas. (divisional solicitud 201800415).
JP2019113625A JP6979423B2 (ja) 2015-08-20 2019-06-19 キメラサイトカイン受容体
ZA2019/04156A ZA201904156B (en) 2015-08-20 2019-06-26 Chimeric cytokine receptor
US16/999,012 US11479614B2 (en) 2015-08-20 2020-08-20 Methods for treating cancer or modulating T cells or NK cells in a subject with cancer by administering cells comprising chimeric cytokine receptors
US16/998,756 US11479613B2 (en) 2015-08-20 2020-08-20 Methods for treating cancer or modulating T cells or NK cells in a subject by administering cells comprising chimeric transmembrane proteins
JP2020199336A JP7603426B2 (ja) 2015-08-20 2020-12-01 キメラサイトカイン受容体
US17/815,110 US12234295B2 (en) 2015-08-20 2022-07-26 Chimeric transmembrane protein comprising antibody dimerization domains and a type I cytokine receptor endodomain, encoding nucleic acids thereof and methods of use thereof
JP2022178045A JP2022190153A (ja) 2015-08-20 2022-11-07 キメラサイトカイン受容体
US19/033,252 US20250333538A1 (en) 2015-08-20 2025-01-21 Chimeric cytokine receptor
JP2025047074A JP2025089403A (ja) 2015-08-20 2025-03-21 キメラサイトカイン受容体
JP2025047075A JP2025089404A (ja) 2015-08-20 2025-03-21 キメラサイトカイン受容体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1514875.2A GB201514875D0 (en) 2015-08-20 2015-08-20 Receptor

Publications (1)

Publication Number Publication Date
GB201514875D0 true GB201514875D0 (en) 2015-10-07

Family

ID=54292003

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1514875.2A Ceased GB201514875D0 (en) 2015-08-20 2015-08-20 Receptor

Country Status (18)

Country Link
US (6) US10800854B2 (enExample)
EP (3) EP3337814A1 (enExample)
JP (6) JP2018523485A (enExample)
KR (2) KR102669749B1 (enExample)
CN (2) CN110724200B (enExample)
AU (1) AU2016308618B2 (enExample)
BR (1) BR112018003308A2 (enExample)
CA (2) CA2995785A1 (enExample)
CL (2) CL2018000415A1 (enExample)
ES (1) ES3076016T3 (enExample)
GB (1) GB201514875D0 (enExample)
HK (1) HK1252161A1 (enExample)
IL (2) IL270207B2 (enExample)
MX (2) MX2018002042A (enExample)
RU (1) RU2018109350A (enExample)
SG (1) SG10201909759UA (enExample)
WO (1) WO2017029512A1 (enExample)
ZA (1) ZA201904156B (enExample)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
EP3805371A1 (en) 2014-05-15 2021-04-14 National University of Singapore Modified natural killer cells and uses thereof
GB201514875D0 (en) 2015-08-20 2015-10-07 Autolus Ltd Receptor
GB201518816D0 (en) 2015-10-23 2015-12-09 Autolus Ltd Receptor
CA3019835A1 (en) 2016-04-08 2017-10-12 Purdue Research Foundation Methods and compositions for car t cell therapy
US11654158B2 (en) 2016-11-17 2023-05-23 2Seventy Bio, Inc. TGFBeta signal convertor
CA3045667A1 (en) * 2016-12-13 2018-06-21 Seattle Children's Hospital (dba Seattle Children's Research Institute) Methods of exogenous drug activation of chemical-induced signaling complexes expressed in engineered cells in vitro and in vivo
AU2018219226B2 (en) 2017-02-07 2024-12-19 Seattle Children's Hospital (dba Seattle Children's Research Institute) Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
CN110582288B (zh) 2017-02-28 2024-09-20 恩多塞特公司 用于car t细胞疗法的组合物和方法
CN117363636A (zh) 2017-03-27 2024-01-09 新加坡国立大学 一种编码嵌合受体的多核苷酸
JP2020532987A (ja) * 2017-09-08 2020-11-19 ポセイダ セラピューティクス，インコーポレイティド キメラリガンド受容体（ｃｌｒ）介在性の条件遺伝子発現のための組成物および方法
GB201714718D0 (en) * 2017-09-13 2017-10-25 Autolus Ltd Cell
GB201716728D0 (en) 2017-10-12 2017-11-29 Autolus Ltd Cell
GB201717524D0 (en) 2017-10-25 2017-12-06 Autolus Ltd Vectors
GB201719557D0 (en) 2017-11-24 2018-01-10 Autolus Ltd Polypeptide
CA3084551A1 (en) * 2017-12-14 2019-06-20 Bluebird Bio, Inc. Daric interleukin receptors
WO2019144095A1 (en) 2018-01-22 2019-07-25 Seattle Children's Hospital (dba Seattle Children's Research Institute) Methods of use for car t cells
GB201801831D0 (en) * 2018-02-05 2018-03-21 Autolus Ltd Chimeric receptor
AU2019218729B2 (en) 2018-02-06 2025-12-04 Seattle Children's Hospital (dba Seattle Children's Research Institute) Fluorescein-specific CARs exhibiting optimal T cell function against FL-PLE labelled tumors
JP7568224B2 (ja) 2018-02-23 2024-10-16 エンドサイト・インコーポレイテッド Ｃａｒ ｔ細胞療法のための配列決定法
AU2019227979B2 (en) * 2018-03-02 2024-09-05 Allogene Therapeutics, Inc. Inducible chimeric cytokine receptors
US12441787B2 (en) 2018-04-02 2025-10-14 National University Of Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
SG11202009975TA (en) 2018-04-12 2020-11-27 Umoja Biopharma Inc Viral vectors and packaging cell lines
CA3091490A1 (en) 2018-04-27 2019-10-31 Seattle Children's Hospital (dba Seattle Children's Research Institute) Rapamycin resistant cells
CN112469440B (zh) 2018-06-18 2024-09-06 优瑞科生物技术公司 靶向前列腺特异性膜抗原(psma)的构建体和其用途
CN110615843B (zh) * 2018-06-20 2023-05-09 上海隆耀生物科技有限公司 一种包含第三信号受体的嵌合抗原受体及其应用
GB201812474D0 (en) 2018-07-31 2018-09-12 Autolus Ltd Nucleic acid construct
WO2020044239A1 (en) * 2018-08-29 2020-03-05 National University Of Singapore A method to specifically stimulate survival and expansion of genetically-modified immune cells
SG11202102781UA (en) 2018-09-27 2021-04-29 Autolus Ltd Chimeric antigen receptor
US20200147137A1 (en) * 2018-11-08 2020-05-14 WUGEN, Inc. Compositions and methods for treatment of cancer
CN111378046B (zh) * 2018-12-27 2024-03-15 上海细胞治疗集团有限公司 一种免疫效应细胞转换受体
IL285941B1 (en) * 2019-03-01 2026-08-01 Allogene Therapeutics Inc Cytokine chemoreceptors bearing the PD-1 ECTODOMAIN
IL328846A (en) 2019-03-01 2026-08-01 Allogene Therapeutics Inc Constitutively active chimeric cytokine receptors and compounds comprising them for the treatment of cancer and autoimmune diseases
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
EP3934666A1 (en) * 2019-03-08 2022-01-12 Autolus Limited Compositions and methods comprising engineered chimeric antigen receptor and modulator of car
GB201903237D0 (en) 2019-03-08 2019-04-24 Autolus Ltd Method
EP3714941A1 (en) 2019-03-27 2020-09-30 Medigene Immunotherapies GmbH Mage-a4 tcrs
MA55911A (fr) 2019-05-08 2022-03-16 2Seventy Bio Inc Lymphocytes t génétiquement modifiés
GB201911187D0 (en) 2019-08-05 2019-09-18 Autolus Ltd Receptor
BR112022003553A2 (pt) 2019-08-30 2022-05-24 Allogene Therapeutics Inc Receptores de citocina quiméricos compreendendo domínios de ligação a tgf beta
WO2021050752A1 (en) * 2019-09-11 2021-03-18 The Board Of Trustees Of The Leland Stanford Junior University Chimeric orthogonal receptor proteins and methods of use
KR102275668B1 (ko) * 2019-09-26 2021-07-12 충북대학교 산학협력단 면역신호의 변환이 가능한 키메릭 사이토카인 수용체, 이를 발현하는 면역세포 및 이의 항암 용도
EP4041299A4 (en) * 2019-10-10 2024-07-31 Bryologyx Inc. Method of induction of tumor associated antigens with bryostatin
IL295063A (en) 2020-02-04 2022-09-01 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Chimeric antigen receptors (car) against dinitrophenol
PE20221757A1 (es) 2020-02-24 2022-11-11 Allogene Therapeutics Inc Celulas t con car de bcma con actividades mejoradas
US20230138428A1 (en) * 2020-02-25 2023-05-04 Quell Therapeutics Limited Chimeric receptors for use in engineered cells
JP7840865B2 (ja) 2020-03-31 2026-04-06 フレッド ハッチンソン キャンサー センター キメラ抗原受容体ターゲティングｃｄ３３
EP4126925A4 (en) * 2020-03-31 2024-07-24 Fred Hutchinson Cancer Center CHIMERIC ANTIGEN RECEPTORS TARGETED AGAINST CD33
EP4132962A1 (en) 2020-04-09 2023-02-15 Autolus Limited Molecule
GB202101491D0 (en) 2021-02-03 2021-03-17 Autolus Ltd Molecule
GB202007044D0 (en) 2020-05-13 2020-06-24 Autolus Ltd Method
CN113201063B (zh) * 2020-07-31 2022-04-19 北京市神经外科研究所 IL7Rα的截短体及其在制备治疗肿瘤的药物中的用途
WO2022037562A1 (en) * 2020-08-17 2022-02-24 Nanjing Legend Biotech Co., Ltd. Engineered immunoresponsive cells and uses thereof
JP7557042B2 (ja) * 2020-08-19 2024-09-26 山東博安生物技術股▲ふん▼有限公司 ステルスキメラ抗原受容体及び正常細胞への細胞毒性の低減におけるその用途
CN112961248B (zh) * 2021-02-22 2022-03-18 广州百暨基因科技有限公司 共表达IL-7和CCR2b的嵌合抗原受体融合蛋白及其应用
CA3217252A1 (en) * 2021-04-19 2022-10-27 Nanjing Legend Biotech Co., Ltd. Chimeric cytokine receptors and uses thereof in cellular therapies
CN113072648B (zh) * 2021-06-04 2021-08-24 诺未科技（北京）有限公司 一种靶向afp的肝癌疫苗
CN113416708A (zh) * 2021-06-10 2021-09-21 深圳市先康达生命科学有限公司 一种表达细胞因子受体融合型嵌合抗原受体的免疫细胞及其应用
KR102827437B1 (ko) * 2021-08-30 2025-07-02 연세대학교 산학협력단 림프종의 예방 또는 치료를 위한 림프종 세포 특이적 약물 전달체 및 이의 제조방법
EP4402161A1 (en) * 2021-09-17 2024-07-24 Parker Institute For Cancer Immunotherapy Switch receptors using il-9 signaling domains
GB202115329D0 (en) 2021-10-25 2021-12-08 Autolus Ltd Chimeric cytokine receptor
EP4519294A1 (en) * 2022-05-04 2025-03-12 Earli Inc. Methods using surface-expressable activatable epitopes to localize and/or treat diseased cells
CA3259305A1 (en) * 2022-07-11 2024-01-18 Sonoma Biotherapeutics, Inc. RECOMBINANT CYTOKINE RECEPTORS AND METHODS OF USE
JP2025529913A (ja) * 2022-08-26 2025-09-09 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー キメラサイトカイン受容体及び使用方法
CN117402262A (zh) * 2022-10-19 2024-01-16 上海君赛生物科技有限公司 基于lag3的嵌合免疫细胞辅助受体及其用途
EP4630446A1 (en) * 2022-12-06 2025-10-15 Dynamic Cell Therapies, Inc. Engineered switches for immune cell activity and methods of use thereof
EP4403580A1 (en) 2023-01-23 2024-07-24 Medizinische Hochschule Hannover Anti-entpd3 chimeric antigen receptor
JP2026507781A (ja) 2023-01-23 2026-03-06 メディツィニシェ ホゥーシュル ハノーファー キメラ抗原受容体
CN120787258A (zh) 2023-02-07 2025-10-14 圭尔医疗有限公司 Treg细胞培养方法
EP4420676A1 (en) 2023-02-24 2024-08-28 Medizinische Hochschule Hannover Chimeric antigen receptor
WO2024175805A1 (en) 2023-02-24 2024-08-29 Medizinische Hochschule Hannover Chimeric antigen receptor
TW202442689A (zh) 2023-03-03 2024-11-01 美商亞森諾生物科學公司 靶向ｐｓｍａ及ｃａ９之系統
EP4680748A1 (en) 2023-03-13 2026-01-21 Arsenal Biosciences, Inc. Synthetic pathway activators
WO2024194605A1 (en) 2023-03-17 2024-09-26 Quell Therapeutics Limited Treg therapy
WO2024194355A1 (en) 2023-03-20 2024-09-26 Medizinische Hochschule Hannover Chimeric antigen receptor
EP4434539A1 (en) 2023-03-20 2024-09-25 Medizinische Hochschule Hannover Chimeric antigen receptor
AU2024240076A1 (en) 2023-03-20 2025-08-28 Autolus Limited A chimeric cytokine receptor, which comprises a truncated il2rbeta and il2rgamma
WO2024238287A1 (en) * 2023-05-12 2024-11-21 Chimeris Uk Ltd. Dual blocking and chimeric cytokine receptor
GB202309704D0 (en) 2023-06-27 2023-08-09 Autolus Ltd Chimeric transmembrane protein
GB202312009D0 (en) 2023-08-04 2023-09-20 Autolus Ltd Methods and cell compositions
WO2025189046A2 (en) * 2024-03-06 2025-09-12 The Johns Hopkins University Pantigen specific cytokine receptor stimulation of immune cell function
WO2025221843A1 (en) * 2024-04-17 2025-10-23 Baylor College Of Medicine Methods and compositions for suppressing immune cell activation
US20260176598A1 (en) 2024-07-04 2026-06-25 Quell Therapeutics Limited Expression construct
GB202411558D0 (en) 2024-08-06 2024-09-18 Quell Therapeutics Ltd Culture method
WO2026149447A1 (zh) * 2025-01-07 2026-07-16 深圳市济因生物科技有限公司 一种颗粒及其应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08508889A (ja) 1993-06-07 1996-09-24 アムジエン・インコーポレーテツド ハイブリッドレセプター分子
GB9526131D0 (en) 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Recombinant chimeric receptors
NZ507886A (en) * 1998-05-19 2003-05-30 Avidex Ltd Multivalent T cell receptor complexes
JP4009535B2 (ja) * 2001-03-09 2007-11-14 ザイモジェネティクス，インコーポレイティド 可溶性ヘテロダイマーサイトカイン受容体
CN1659274A (zh) * 2002-04-19 2005-08-24 津莫吉尼蒂克斯公司 细胞因子受体
JP2004113062A (ja) * 2002-09-25 2004-04-15 Teruyuki Nagamune キメラ受容体を有する動物細胞とその利用
CN101027079B (zh) * 2004-10-12 2011-08-17 美国蛋白质公司 嵌合蛋白
WO2007115230A2 (en) * 2006-03-30 2007-10-11 University Of Medicine And Dentistry Of New Jersey A strategy for homo- or hetero-dimerization of various proteins in solutions and in cells
US20100105136A1 (en) 2006-10-09 2010-04-29 The General Hospital Corporation Chimeric t-cell receptors and t-cells targeting egfrviii on tumors
WO2009003145A1 (en) 2007-06-26 2008-12-31 University Of Miami Antibody-endostatin fusion protein and its variants
EP2389443B1 (en) * 2009-01-23 2018-11-14 Roger Williams Hospital Retroviral vectors encoding multiple highly homologous non-viral polypeptides and the use of same
WO2011034660A1 (en) 2009-09-16 2011-03-24 Immunomedics, Inc. Class i anti-cea antibodies and uses thereof
EP2694640B1 (en) 2011-04-08 2017-10-18 Baylor College Of Medicine Reversing the effects of the tumor microenvironment using chimeric cytokine receptors
EP2814846B1 (en) 2012-02-13 2020-01-08 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
RU2522004C2 (ru) 2012-04-10 2014-07-10 Владимир Константинович Боженко Одноцепочечное антитело к раково-эмбриональному антигену, химерный мономолекулярный т-клеточный рецептор, вектор и клетка-хозяин для обеспечения экспрессии такого рецептора и способ диагностики или лечения.
US20130280220A1 (en) 2012-04-20 2013-10-24 Nabil Ahmed Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes
GB201405845D0 (en) 2014-04-01 2014-05-14 Ucl Business Plc Signalling system
MA41538A (fr) 2014-10-17 2017-12-26 Baylor College Medicine Cellules immunitaires bipartites et tripartites de signalisation
GB201514875D0 (en) 2015-08-20 2015-10-07 Autolus Ltd Receptor
GB201518816D0 (en) 2015-10-23 2015-12-09 Autolus Ltd Receptor
GB201518817D0 (en) 2015-10-23 2015-12-09 Autolus Ltd Cell
GB201719557D0 (en) 2017-11-24 2018-01-10 Autolus Ltd Polypeptide
SG11202102781UA (en) 2018-09-27 2021-04-29 Autolus Ltd Chimeric antigen receptor

Also Published As

Publication number Publication date
WO2017029512A1 (en) 2017-02-23
ZA201904156B (en) 2025-09-25
SG10201909759UA (en) 2019-11-28
US10800854B2 (en) 2020-10-13
US20230133682A1 (en) 2023-05-04
CN110724200A (zh) 2020-01-24
JP2018523485A (ja) 2018-08-23
HK1252161A1 (zh) 2019-05-17
CL2018000415A1 (es) 2018-07-20
IL257234A (en) 2018-03-29
IL270207A (enExample) 2019-12-31
EP4338756A2 (en) 2024-03-20
CN110724200B (zh) 2024-01-26
CA2995785A1 (en) 2017-02-23
CN108350047A (zh) 2018-07-31
JP6979423B2 (ja) 2021-12-15
IL270207B2 (en) 2024-06-01
MX421045B (es) 2025-02-10
JP7603426B2 (ja) 2024-12-20
CA3091907A1 (en) 2017-02-23
US20250333538A1 (en) 2025-10-30
US20190016820A1 (en) 2019-01-17
JP2025089403A (ja) 2025-06-12
EP4338756A3 (en) 2024-06-05
CL2019001107A1 (es) 2019-07-05
KR20180054625A (ko) 2018-05-24
MX2019013204A (es) 2020-01-21
EP3438123A1 (en) 2019-02-06
AU2016308618B2 (en) 2021-05-13
MX2018002042A (es) 2018-06-19
CA3091907C (en) 2023-10-31
US10800855B2 (en) 2020-10-13
BR112018003308A2 (pt) 2018-09-18
US11479614B2 (en) 2022-10-25
NZ739942A (en) 2022-03-25
JP2019150066A (ja) 2019-09-12
AU2016308618A1 (en) 2018-03-08
US20210040228A1 (en) 2021-02-11
KR20240093884A (ko) 2024-06-24
EP3438123B1 (en) 2026-06-03
KR102669749B1 (ko) 2024-05-28
US20180244797A1 (en) 2018-08-30
IL270207B1 (en) 2024-02-01
JP2022190153A (ja) 2022-12-22
ES3076016T3 (en) 2026-08-11
RU2018109350A3 (enExample) 2019-12-09
US20210040227A1 (en) 2021-02-11
US12234295B2 (en) 2025-02-25
US11479613B2 (en) 2022-10-25
JP2021035395A (ja) 2021-03-04
RU2018109350A (ru) 2019-09-23
EP3337814A1 (en) 2018-06-27
JP2025089404A (ja) 2025-06-12

Similar Documents

Publication Publication Date Title
GB201518816D0 (en) Receptor
DK3389557T3 (en) Transseptalt leveringssystem
DK3320033T3 (en) Polyethylenterephthalat-depolymerisering
DK3256579T3 (en) Cysteinprotease
DK3256580T3 (en) Cysteinprotease
DK3250592T3 (en) Anti-transthyretin-antistoffer
DK3298030T3 (en) Anti-cancerfusionspolypeptid
DK3373882T3 (en) Patientisolator
GB201500806D0 (en) Aerosol-gnerating aticle
DK3284069T3 (en) Pos-terminal
GB201702617D0 (en) Receptor
DK3336185T3 (en) Antistof
DK3272750T3 (en) Morphinan-derivat
DK3390996T3 (en) Trykbart tids-temperaturindikatorsystem
DK3380145T3 (en) Injektionsapparat
DK3324768T3 (en) Tørdragt
PL3245344T3 (pl) Konstrukcja słupowo-ryglowa
AU361999S (en) Ballustrade
DK3133099T3 (en) Polymermodificeret polyoldispersion
DK3250312T3 (en) Urea-metalnitrat-scr-system
DK3242882T3 (en) Cgrp-antagonistpeptider
DK3294653T3 (en) Justerbar inline-port
DK3282866T3 (en) Proteinfibre
GB2535510B (en) Fixing means
GB201701887D0 (en) Receptor

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)