GB201020179D0 - New compounds - Google Patents
New compoundsInfo
- Publication number
- GB201020179D0 GB201020179D0 GBGB1020179.6A GB201020179A GB201020179D0 GB 201020179 D0 GB201020179 D0 GB 201020179D0 GB 201020179 A GB201020179 A GB 201020179A GB 201020179 D0 GB201020179 D0 GB 201020179D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- new compounds
- compounds
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1020179.6A GB201020179D0 (en) | 2010-11-29 | 2010-11-29 | New compounds |
| KR1020137016924A KR101914720B1 (ko) | 2010-11-29 | 2011-11-29 | 암 질환의 치료를 위한 fgfr 키나제 억제제로서의 치환된 벤조피라진 유도체 |
| EP11805567.2A EP2646432B1 (en) | 2010-11-29 | 2011-11-29 | Substituted benzopyrazin derivatives as fgfr kinase inhibitors for the treatment of cancer diseases |
| CN201180066231.7A CN103370314B (zh) | 2010-11-29 | 2011-11-29 | 作为用于治疗癌症疾病的fgfr激酶抑制剂的取代苯并吡嗪衍生物 |
| HUE11805567A HUE025091T2 (en) | 2010-11-29 | 2011-11-29 | Substituted benzopyrazine derivatives as FGFR kinase inhibitors for the treatment of cancer diseases |
| ES11805567.2T ES2541493T3 (es) | 2010-11-29 | 2011-11-29 | Derivados de benzopirazina sustituida como inhibidores de FGFR quinasa para el tratamiento de enfermedades cancerígenas |
| AU2011334624A AU2011334624B2 (en) | 2010-11-29 | 2011-11-29 | Substituted benzopyrazin derivatives as FGFR kinase inhibitors for the treatment of cancer diseases |
| MX2013005897A MX2013005897A (es) | 2010-11-29 | 2011-11-29 | Derivados de benzopirazina sustituidos como inhibidores de cinasa del receptor del factor de crecimiento de fibroblasto (fgfr) para el tratamiento de enfermedades cancerigenas. |
| HK14101032.2A HK1187916B (en) | 2010-11-29 | 2011-11-29 | Substituted benzopyrazin derivatives as fgfr kinase inhibitors for the treatment of cancer diseases |
| CA2819009A CA2819009C (en) | 2010-11-29 | 2011-11-29 | Substituted benzopyrazin derivatives as fgfr kinase inhibitors for the treatment of cancer diseases |
| HRP20150692TT HRP20150692T8 (en) | 2010-11-29 | 2011-11-29 | Substituted benzopyrazin derivatives as fgfr kinase inhibitors for the treatment of cancer diseases |
| BR112013013435-6A BR112013013435B1 (pt) | 2010-11-29 | 2011-11-29 | composto, composição farmacêutica, uso de um composto,e, processo para a preparação de um composto |
| PCT/GB2011/052356 WO2012073017A1 (en) | 2010-11-29 | 2011-11-29 | Substituted benzopyrazin derivatives as fgfr kinase inhibitors for the treatment of cancer diseases |
| US13/990,193 US9290478B2 (en) | 2010-11-29 | 2011-11-29 | Substituted quinoxalines as FGFR kinase inhibitors |
| JP2013540440A JP5868992B2 (ja) | 2010-11-29 | 2011-11-29 | 癌疾患の治療のためのｆｇｆｒキナーゼ阻害剤としての置換ベンゾピラジン誘導体 |
| DK11805567.2T DK2646432T3 (en) | 2010-11-29 | 2011-11-29 | Substituted benzopyrazine derivatives as FGFR kinase inhibitors for the treatment of cancer |
| RU2013129820/04A RU2602233C2 (ru) | 2010-11-29 | 2011-11-29 | Замещенные бензопиразиновые производные в качестве ингибиторов fgfr-киназ для лечения раковых заболеваний |
| SI201130534T SI2646432T1 (sl) | 2010-11-29 | 2011-11-29 | Substituirani derivati benzopirazina kot inhibitorji FGFR kinaz za zdravljenje rakavih bolezni |
| US14/816,565 US9856236B2 (en) | 2010-11-29 | 2015-08-03 | Substituted quinoxalines as FGFR kinase inhibitors |
| SM201500191T SMT201500191B (it) | 2010-11-29 | 2015-08-06 | Derivati di benzopirazina sostituiti come inibitori delle chinasi fgfr per il trattamento di malattie tumorali |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1020179.6A GB201020179D0 (en) | 2010-11-29 | 2010-11-29 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB201020179D0 true GB201020179D0 (en) | 2011-01-12 |
Family
ID=43500774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB1020179.6A Ceased GB201020179D0 (en) | 2010-11-29 | 2010-11-29 | New compounds |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9290478B2 (enExample) |
| EP (1) | EP2646432B1 (enExample) |
| JP (1) | JP5868992B2 (enExample) |
| KR (1) | KR101914720B1 (enExample) |
| CN (1) | CN103370314B (enExample) |
| AU (1) | AU2011334624B2 (enExample) |
| BR (1) | BR112013013435B1 (enExample) |
| CA (1) | CA2819009C (enExample) |
| DK (1) | DK2646432T3 (enExample) |
| ES (1) | ES2541493T3 (enExample) |
| GB (1) | GB201020179D0 (enExample) |
| HR (1) | HRP20150692T8 (enExample) |
| HU (1) | HUE025091T2 (enExample) |
| MX (1) | MX2013005897A (enExample) |
| RU (1) | RU2602233C2 (enExample) |
| SI (1) | SI2646432T1 (enExample) |
| SM (1) | SMT201500191B (enExample) |
| WO (1) | WO2012073017A1 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
| GB201020179D0 (en) * | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| EP2747767B8 (en) | 2011-08-26 | 2019-07-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| EP2755657B1 (en) | 2011-09-14 | 2017-11-29 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| WO2013043935A1 (en) | 2011-09-21 | 2013-03-28 | Neupharma, Inc. | Certain chemical entites, compositions, and methods |
| WO2013049701A1 (en) | 2011-09-30 | 2013-04-04 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
| GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118652D0 (en) * | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| US9670180B2 (en) | 2012-01-25 | 2017-06-06 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201209609D0 (en) * | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| EP3495367B1 (en) | 2012-06-13 | 2020-09-30 | Incyte Holdings Corporation | Substituted tricyclic compounds as fgfr inhibitors |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| EP2897618B1 (en) | 2012-09-24 | 2021-11-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| WO2014044846A1 (en) | 2012-09-24 | 2014-03-27 | Evotec (Uk) Ltd. | 3-(aryl- or heteroaryl-amino)-7-(3,5-dimethoxyphenyl)isoquinoline derivatives as fgfr inhibitors useful for the treatment of proliferative disorders or dysplasia |
| EP2916838B1 (en) | 2012-11-12 | 2019-03-13 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| DK2986610T5 (en) | 2013-04-19 | 2018-12-10 | Incyte Holdings Corp | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS |
| GB201307577D0 (en) * | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
| EP2924038A1 (en) | 2014-03-24 | 2015-09-30 | Evotec (UK) Ltd. | Preparation of pyrrolo[2,3-b]pyrazine and pyrrolo[2,3-b]pyridine derivatives as FGFR inhibitors |
| RU2715236C2 (ru) | 2014-03-26 | 2020-02-26 | Астекс Терапьютикс Лтд | Комбинации |
| JO3512B1 (ar) * | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
| HUE053653T2 (hu) | 2014-03-26 | 2021-07-28 | Astex Therapeutics Ltd | FGFR inhibitor és IGF1R inhibitor kombinációi |
| RU2658821C1 (ru) | 2014-08-18 | 2018-06-25 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Соль моноциклического производного пиридина и ее кристалл |
| HUE058219T2 (hu) | 2014-09-26 | 2022-07-28 | Janssen Pharmaceutica Nv | FGFR-mutánsgénpanel alkalmazása olyan rákbetegek azonosításában, akik FGFR-inhibitorral történõ kezelésre reszponzívak lesznek |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
| CR20170390A (es) | 2015-02-20 | 2017-10-23 | Incyte Holdings Corp | Heterociclos biciclicos como inhibidores de fgfr |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| CA2974937C (en) | 2015-03-25 | 2023-09-05 | National Cancer Center | Therapeutic agent for bile duct cancer |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| RU2728674C2 (ru) * | 2015-07-24 | 2020-07-30 | Дебиофарм Интернэшнл Са | Экспрессия fgfr и чувствительность к ингибитору fgfr |
| JP6898919B2 (ja) | 2015-09-23 | 2021-07-07 | ヤンセン ファーマシューティカ エヌ．ベー． | 新規化合物 |
| US11542247B2 (en) * | 2015-09-23 | 2023-01-03 | Janssen Pharmaceutica Nv | Bi-heteroaryl substitute 1,4-benzodiazepines and uses thereof for the treatment of cancer |
| CA3002560A1 (en) | 2015-10-23 | 2017-04-27 | Array Biopharma, Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases |
| CN115177619A (zh) | 2015-12-17 | 2022-10-14 | 卫材R&D管理有限公司 | 用于乳腺癌的治疗剂 |
| CN110325515B (zh) * | 2016-10-10 | 2023-06-20 | 财团法人生物技术开发中心 | 作为ⅲ型受体酪氨酸激酶抑制剂的喹喔啉化合物 |
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| KR20200135945A (ko) | 2018-03-28 | 2020-12-04 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 간세포 암종 치료제 |
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| CN112566912A (zh) | 2018-05-04 | 2021-03-26 | 因赛特公司 | Fgfr抑制剂的盐 |
| MX2020013757A (es) * | 2018-09-14 | 2021-03-02 | Abbisko Therapeutics Co Ltd | Inhibidor del fgfr, metodo de preparacion y aplicacion del mismo. |
| JP2022515198A (ja) | 2018-12-19 | 2022-02-17 | アレイ バイオファーマ インコーポレイテッド | ＦＧＦＲチロシンキナーゼの阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物 |
| WO2020131674A1 (en) | 2018-12-19 | 2020-06-25 | Array Biopharma Inc. | 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| ES2960702T3 (es) * | 2019-08-08 | 2024-03-06 | Zhangzhou Pien Tze Huang Pharm | Formas cristalinas C y E del compuesto de pirazin-2(1H)-ona y método de preparación de las mismas |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| GEAP202415945A (en) | 2019-10-14 | 2024-04-25 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CR20230325A (es) | 2020-12-30 | 2023-12-11 | Tyra Biosciences Inc | Compuestos de indazol como inhibidores de cinasas |
| BR112023016986A2 (pt) | 2021-02-26 | 2023-11-07 | Tyra Biosciences Inc | Compostos de aminopirimidina e métodos de seu uso |
| TW202304459A (zh) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法 |
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Also Published As
| Publication number | Publication date |
|---|---|
| RU2602233C2 (ru) | 2016-11-10 |
| US20160031856A1 (en) | 2016-02-04 |
| US20130267525A1 (en) | 2013-10-10 |
| BR112013013435A2 (pt) | 2016-10-11 |
| AU2011334624A1 (en) | 2013-06-13 |
| WO2012073017A1 (en) | 2012-06-07 |
| CA2819009C (en) | 2020-02-25 |
| AU2011334624B2 (en) | 2016-09-15 |
| JP5868992B2 (ja) | 2016-02-24 |
| BR112013013435B1 (pt) | 2020-10-20 |
| HK1187916A1 (en) | 2014-04-17 |
| SI2646432T1 (sl) | 2015-08-31 |
| ES2541493T3 (es) | 2015-07-21 |
| JP2013543883A (ja) | 2013-12-09 |
| CN103370314A (zh) | 2013-10-23 |
| CA2819009A1 (en) | 2012-06-07 |
| RU2013129820A (ru) | 2015-01-10 |
| KR101914720B1 (ko) | 2018-11-05 |
| SMT201500191B (it) | 2015-09-07 |
| HRP20150692T8 (en) | 2015-09-25 |
| HUE025091T2 (en) | 2016-01-28 |
| US9290478B2 (en) | 2016-03-22 |
| EP2646432B1 (en) | 2015-04-08 |
| CN103370314B (zh) | 2015-10-21 |
| HRP20150692T1 (hr) | 2015-08-14 |
| MX2013005897A (es) | 2013-10-25 |
| EP2646432A1 (en) | 2013-10-09 |
| KR20130132509A (ko) | 2013-12-04 |
| US9856236B2 (en) | 2018-01-02 |
| DK2646432T3 (en) | 2015-07-13 |
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