SMT201500191B - Derivati di benzopirazina sostituiti come inibitori delle chinasi fgfr per il trattamento di malattie tumorali - Google Patents

Derivati di benzopirazina sostituiti come inibitori delle chinasi fgfr per il trattamento di malattie tumorali

Info

Publication number
SMT201500191B
SMT201500191B SM201500191T SM201500191T SMT201500191B SM T201500191 B SMT201500191 B SM T201500191B SM 201500191 T SM201500191 T SM 201500191T SM 201500191 T SM201500191 T SM 201500191T SM T201500191 B SMT201500191 B SM T201500191B
Authority
SM
San Marino
Prior art keywords
benzopyrazine
treatment
kinase inhibitors
tumor diseases
derivatives substituted
Prior art date
Application number
SM201500191T
Other languages
English (en)
Inventor
Valerio Berdini
Gordon Saxty
Christopher William Murray
Gilbert Ebai Besong
Christopher Charles Frederick Hamlett
Steven John Woodhead
Yannick Aime Eddy Ligny
Patrick Rene Angibaud
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of SMT201500191B publication Critical patent/SMT201500191B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SM201500191T 2010-11-29 2015-08-06 Derivati di benzopirazina sostituiti come inibitori delle chinasi fgfr per il trattamento di malattie tumorali SMT201500191B (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41774410P 2010-11-29 2010-11-29
GBGB1020179.6A GB201020179D0 (en) 2010-11-29 2010-11-29 New compounds
PCT/GB2011/052356 WO2012073017A1 (en) 2010-11-29 2011-11-29 Substituted benzopyrazin derivatives as fgfr kinase inhibitors for the treatment of cancer diseases

Publications (1)

Publication Number Publication Date
SMT201500191B true SMT201500191B (it) 2015-09-07

Family

ID=43500774

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201500191T SMT201500191B (it) 2010-11-29 2015-08-06 Derivati di benzopirazina sostituiti come inibitori delle chinasi fgfr per il trattamento di malattie tumorali

Country Status (19)

Country Link
US (2) US9290478B2 (it)
EP (1) EP2646432B1 (it)
JP (1) JP5868992B2 (it)
KR (1) KR101914720B1 (it)
CN (1) CN103370314B (it)
AU (1) AU2011334624B2 (it)
BR (1) BR112013013435B1 (it)
CA (1) CA2819009C (it)
DK (1) DK2646432T3 (it)
ES (1) ES2541493T3 (it)
GB (1) GB201020179D0 (it)
HK (1) HK1187916A1 (it)
HR (1) HRP20150692T8 (it)
HU (1) HUE025091T2 (it)
MX (1) MX2013005897A (it)
RU (1) RU2602233C2 (it)
SI (1) SI2646432T1 (it)
SM (1) SMT201500191B (it)
WO (1) WO2012073017A1 (it)

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