GB1592053A - Oxytetracycline compositions - Google Patents
Oxytetracycline compositions Download PDFInfo
- Publication number
- GB1592053A GB1592053A GB5249676A GB5249676A GB1592053A GB 1592053 A GB1592053 A GB 1592053A GB 5249676 A GB5249676 A GB 5249676A GB 5249676 A GB5249676 A GB 5249676A GB 1592053 A GB1592053 A GB 1592053A
- Authority
- GB
- United Kingdom
- Prior art keywords
- oxytetracycline
- acid
- amide
- solution
- polyvinylpyrrolidone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title claims 7
- 239000004100 Oxytetracycline Substances 0.000 title claims 5
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 title claims 5
- 229960000625 oxytetracycline Drugs 0.000 title claims 5
- 235000019366 oxytetracycline Nutrition 0.000 title claims 5
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 title claims 5
- 238000000034 method Methods 0.000 claims 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 2
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 2
- 150000008431 aliphatic amides Chemical class 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical group CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims 1
- SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical compound NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000001361 adipic acid Substances 0.000 claims 1
- 235000011037 adipic acid Nutrition 0.000 claims 1
- 229910001420 alkaline earth metal ion Inorganic materials 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000000174 gluconic acid Substances 0.000 claims 1
- 235000012208 gluconic acid Nutrition 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 229910001425 magnesium ion Inorganic materials 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 150000007530 organic bases Chemical class 0.000 claims 1
- 238000010979 pH adjustment Methods 0.000 claims 1
- 229960000581 salicylamide Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5249676A GB1592053A (en) | 1976-12-16 | 1976-12-16 | Oxytetracycline compositions |
| DE19772754882 DE2754882A1 (de) | 1976-12-16 | 1977-12-09 | Pharmazeutische zusammensetzungen |
| NL7713761A NL7713761A (nl) | 1976-12-16 | 1977-12-13 | Oxytetracycline bevattende farmaceutische pre- paraten en werkwijze ter bereiding daarvan. |
| AU31486/77A AU514852B2 (en) | 1976-12-16 | 1977-12-13 | Stable solutions of oxytetracycline |
| JP14893377A JPS5394028A (en) | 1976-12-16 | 1977-12-13 | Pharmaceutical composition and production thereof |
| BE183458A BE861855A (fr) | 1976-12-16 | 1977-12-14 | Solutions stables d'oxytetracycline |
| PT6740277A PT67402B (en) | 1976-12-16 | 1977-12-14 | Process for the preparation of pharmaceutical compositionscomprising stable solutions of oxytetracycline |
| ES465065A ES465065A1 (es) | 1976-12-16 | 1977-12-14 | Un metodo de preparar una composicion farmaceutica que con- tiene oxitetraciclina |
| FR7737829A FR2374041A1 (fr) | 1976-12-16 | 1977-12-15 | Solutions stables d'oxytetracycline |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5249676A GB1592053A (en) | 1976-12-16 | 1976-12-16 | Oxytetracycline compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1592053A true GB1592053A (en) | 1981-07-01 |
Family
ID=10464140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5249676A Expired GB1592053A (en) | 1976-12-16 | 1976-12-16 | Oxytetracycline compositions |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5394028A (enExample) |
| AU (1) | AU514852B2 (enExample) |
| BE (1) | BE861855A (enExample) |
| DE (1) | DE2754882A1 (enExample) |
| ES (1) | ES465065A1 (enExample) |
| FR (1) | FR2374041A1 (enExample) |
| GB (1) | GB1592053A (enExample) |
| NL (1) | NL7713761A (enExample) |
| PT (1) | PT67402B (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0096942A3 (en) * | 1982-06-15 | 1984-02-15 | Aesculaap B.V. | Process for preparing an oxytetracycline composition |
| EP0649655A1 (en) * | 1993-10-15 | 1995-04-26 | Takeda Chemical Industries, Ltd. | Injectable solutions containing anti-ulcer benzimidazoles and amides |
| US11421207B2 (en) | 2017-11-28 | 2022-08-23 | C-Lecta Gmbh | Method for producing trehalose employing a trehalose phosphorylase variant |
| US11426351B2 (en) | 2019-12-26 | 2022-08-30 | Sunstar Inc. | Process for producing a pharmaceutical composition containing micro particles |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7872059B2 (en) * | 2007-02-14 | 2011-01-18 | Fujifilm Corporation | Composition for use in laser decomposition and pattern-forming material using the same |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2990331A (en) * | 1956-11-23 | 1961-06-27 | Pfizer & Co C | Stable solutions of salts of tetracyclines for parenteral administration |
| NL6607516A (enExample) * | 1966-05-31 | 1967-12-01 | ||
| DE1767891C3 (de) * | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
| BE786427A (fr) * | 1971-07-19 | 1973-01-18 | Pfizer | Compositions aqueuses de doxycycline |
| DK129969B (da) * | 1973-01-11 | 1974-12-09 | Rosco Ak | Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin. |
| GB1508601A (en) * | 1974-01-19 | 1978-04-26 | Norbrook Labor Ltd | Oxytetracycline solution |
-
1976
- 1976-12-16 GB GB5249676A patent/GB1592053A/en not_active Expired
-
1977
- 1977-12-09 DE DE19772754882 patent/DE2754882A1/de not_active Ceased
- 1977-12-13 JP JP14893377A patent/JPS5394028A/ja active Pending
- 1977-12-13 AU AU31486/77A patent/AU514852B2/en not_active Expired
- 1977-12-13 NL NL7713761A patent/NL7713761A/xx not_active Application Discontinuation
- 1977-12-14 BE BE183458A patent/BE861855A/xx not_active IP Right Cessation
- 1977-12-14 ES ES465065A patent/ES465065A1/es not_active Expired
- 1977-12-14 PT PT6740277A patent/PT67402B/pt unknown
- 1977-12-15 FR FR7737829A patent/FR2374041A1/fr active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0096942A3 (en) * | 1982-06-15 | 1984-02-15 | Aesculaap B.V. | Process for preparing an oxytetracycline composition |
| EP0649655A1 (en) * | 1993-10-15 | 1995-04-26 | Takeda Chemical Industries, Ltd. | Injectable solutions containing anti-ulcer benzimidazoles and amides |
| US11421207B2 (en) | 2017-11-28 | 2022-08-23 | C-Lecta Gmbh | Method for producing trehalose employing a trehalose phosphorylase variant |
| US11426351B2 (en) | 2019-12-26 | 2022-08-30 | Sunstar Inc. | Process for producing a pharmaceutical composition containing micro particles |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5394028A (en) | 1978-08-17 |
| AU514852B2 (en) | 1981-03-05 |
| PT67402A (en) | 1978-01-01 |
| NL7713761A (nl) | 1978-06-20 |
| DE2754882A1 (de) | 1978-07-06 |
| PT67402B (en) | 1979-05-21 |
| ES465065A1 (es) | 1979-01-16 |
| FR2374041A1 (fr) | 1978-07-13 |
| BE861855A (fr) | 1978-06-14 |
| AU3148677A (en) | 1979-06-21 |
| FR2374041B1 (enExample) | 1981-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee | ||
| 728C | Application made for restoration (sect. 28/1977) | ||
| 728W | Application withdrawn (sect. 28/1977) |