GB1570990A - Derivatives of thienamycin and its isomers - Google Patents

Derivatives of thienamycin and its isomers Download PDF

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Publication number
GB1570990A
GB1570990A GB48240/76A GB4824076A GB1570990A GB 1570990 A GB1570990 A GB 1570990A GB 48240/76 A GB48240/76 A GB 48240/76A GB 4824076 A GB4824076 A GB 4824076A GB 1570990 A GB1570990 A GB 1570990A
Authority
GB
United Kingdom
Prior art keywords
compound
alkyl
formula
composition
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB48240/76A
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English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1570990A publication Critical patent/GB1570990A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GB48240/76A 1975-11-21 1976-11-19 Derivatives of thienamycin and its isomers Expired GB1570990A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63429675A 1975-11-21 1975-11-21
US67626176A 1976-04-12 1976-04-12
US73365476A 1976-10-18 1976-10-18

Publications (1)

Publication Number Publication Date
GB1570990A true GB1570990A (en) 1980-07-09

Family

ID=27417545

Family Applications (1)

Application Number Title Priority Date Filing Date
GB48240/76A Expired GB1570990A (en) 1975-11-21 1976-11-19 Derivatives of thienamycin and its isomers

Country Status (27)

Country Link
AT (1) AT358168B (enExample)
AU (1) AU512383B2 (enExample)
BG (1) BG34037A3 (enExample)
CA (1) CA1083577A (enExample)
CH (2) CH632510A5 (enExample)
DD (1) DD127742A5 (enExample)
DE (1) DE2652679A1 (enExample)
DK (1) DK157401C (enExample)
EG (1) EG12261A (enExample)
ES (1) ES453501A1 (enExample)
FI (1) FI62306C (enExample)
FR (1) FR2332012A1 (enExample)
GB (1) GB1570990A (enExample)
GR (1) GR62072B (enExample)
HK (1) HK29683A (enExample)
HU (1) HU180865B (enExample)
IE (1) IE44433B1 (enExample)
IL (1) IL50911A (enExample)
KE (1) KE3286A (enExample)
NL (1) NL189297C (enExample)
NO (1) NO153298C (enExample)
NZ (1) NZ182630A (enExample)
PH (1) PH16714A (enExample)
PL (1) PL110937B1 (enExample)
PT (1) PT65865B (enExample)
SE (1) SE427841B (enExample)
SG (1) SG10983G (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0044170A1 (en) * 1980-07-11 1982-01-20 Beecham Group Plc Beta-lactam antibiotics, their preparation and use

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
DK170778A (da) * 1977-05-05 1979-01-15 Merck & Co Inc Fremgangsmaade til fremstilling af n-alkyl-n-iminomethyl-derivater af thienamycin
US4232030A (en) * 1977-09-15 1980-11-04 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone
DK153486C (da) * 1978-07-03 1988-11-28 Merck & Co Inc Analogifremgangsmaade til fremstilling af krystallinsk n-formimidoyl-thienamycin-monohydrat
WO1992004054A1 (en) * 1990-08-30 1992-03-19 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITY, PORTLAND, OREGON, and THE UNIVERSITY OF OREGON, EUGENE, OREGON, Johnson Hall, University of Oregon Substituted amidines having high binding to the sigma receptor and the use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1004670A (en) * 1963-04-23 1965-09-15 Beecham Res Lab Penicillins
GB1348985A (en) * 1970-06-16 1974-03-27 Merck & Co Inc Esters of cephalosporin compounds
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0044170A1 (en) * 1980-07-11 1982-01-20 Beecham Group Plc Beta-lactam antibiotics, their preparation and use

Also Published As

Publication number Publication date
DK157401B (da) 1990-01-02
AT358168B (de) 1980-08-25
IL50911A0 (en) 1977-01-31
FI62306B (fi) 1982-08-31
CH632510A5 (en) 1982-10-15
NL189297B (nl) 1992-10-01
AU512383B2 (en) 1980-10-09
NO153298C (no) 1986-02-19
GR62072B (en) 1979-02-20
CA1083577A (en) 1980-08-12
IE44433B1 (en) 1981-12-02
PT65865A (en) 1976-12-01
NL7612939A (nl) 1977-05-24
ES453501A1 (es) 1978-03-01
EG12261A (en) 1978-12-31
SE7612963L (sv) 1977-05-22
AU1964776A (en) 1978-05-25
FR2332012B1 (enExample) 1978-11-17
FI62306C (fi) 1982-12-10
SG10983G (en) 1983-12-16
PT65865B (en) 1978-10-12
PL193809A1 (pl) 1978-01-16
NO153298B (no) 1985-11-11
IE44433L (en) 1977-05-21
NL189297C (nl) 1993-03-01
DE2652679C2 (enExample) 1990-03-01
FI763308A7 (enExample) 1977-05-22
PL110937B1 (en) 1980-08-30
DK157401C (da) 1990-05-21
DK523576A (da) 1977-05-22
ATA863476A (de) 1980-01-15
SE427841B (sv) 1983-05-09
DE2652679A1 (de) 1977-06-02
NO763958L (enExample) 1977-05-24
BG34037A3 (bg) 1983-06-15
IL50911A (en) 1981-01-30
FR2332012A1 (fr) 1977-06-17
PH16714A (en) 1984-01-25
CH633800A5 (en) 1982-12-31
DD127742A5 (de) 1977-10-12
HK29683A (en) 1983-08-26
NZ182630A (en) 1979-07-11
KE3286A (en) 1983-06-17
HU180865B (en) 1983-04-29

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years

Effective date: 19961118