GB1545094A - Piperazine derivatives - Google Patents

Piperazine derivatives

Info

Publication number
GB1545094A
GB1545094A GB52223/76A GB5222376A GB1545094A GB 1545094 A GB1545094 A GB 1545094A GB 52223/76 A GB52223/76 A GB 52223/76A GB 5222376 A GB5222376 A GB 5222376A GB 1545094 A GB1545094 A GB 1545094A
Authority
GB
United Kingdom
Prior art keywords
piperazine derivatives
piperazine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB52223/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Priority to GB52223/76A priority Critical patent/GB1545094A/en
Priority to IL53597A priority patent/IL53597A0/xx
Priority to IE2541/77A priority patent/IE46278B1/en
Priority to AT0891177A priority patent/AT363090B/de
Priority to ZA00777452A priority patent/ZA777452B/xx
Priority to US05/860,460 priority patent/US4202896A/en
Priority to YU02958/77A priority patent/YU295877A/xx
Priority to NO774307A priority patent/NO148150C/no
Priority to BE183456A priority patent/BE861853A/xx
Priority to AU31573/77A priority patent/AU516920B2/en
Priority to FI773786A priority patent/FI69839C/fi
Priority to ES465047A priority patent/ES465047A1/es
Priority to HU77GI266A priority patent/HU177999B/hu
Priority to LU78686A priority patent/LU78686A1/xx
Priority to PT67400A priority patent/PT67400B/pt
Priority to NL7713817A priority patent/NL7713817A/xx
Priority to IT69793/77A priority patent/IT1093045B/it
Priority to JP15038477A priority patent/JPS5382789A/ja
Priority to FR7737708A priority patent/FR2374318A1/fr
Priority to DK557277A priority patent/DK147421C/da
Priority to DE19772755752 priority patent/DE2755752A1/de
Priority to NZ185981A priority patent/NZ185981A/xx
Priority to SE7714184A priority patent/SE435378B/sv
Priority to ES473814A priority patent/ES473814A1/es
Priority to ES473817A priority patent/ES473817A1/es
Priority to ES473818A priority patent/ES473818A1/es
Priority to ES473815A priority patent/ES473815A1/es
Priority to ES473816A priority patent/ES473816A1/es
Publication of GB1545094A publication Critical patent/GB1545094A/en
Priority to US06/090,257 priority patent/US4265894A/en
Priority to AT712479A priority patent/AT363094B/de
Priority to AT712279A priority patent/AT363092B/de
Priority to AT712379A priority patent/AT363093B/de
Priority to AT712579A priority patent/AT363095B/de
Priority to YU189182A priority patent/YU189182A/xx
Priority to YU189282A priority patent/YU189282A/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB52223/76A 1976-12-14 1976-12-14 Piperazine derivatives Expired GB1545094A (en)

Priority Applications (35)

Application Number Priority Date Filing Date Title
GB52223/76A GB1545094A (en) 1976-12-14 1976-12-14 Piperazine derivatives
IL53597A IL53597A0 (en) 1976-12-14 1977-12-13 Novel piperazine derivatives their preparation and pharmaceutical compositions containing them
JP15038477A JPS5382789A (en) 1976-12-14 1977-12-14 Novel piperadine derivative and method for its production
DK557277A DK147421C (da) 1976-12-14 1977-12-14 Analogifremgangsmaade til fremstilling af piperazinderivater eller syreadditionssalte eller kvaternaere ammoniumsalte deraf
ZA00777452A ZA777452B (en) 1976-12-14 1977-12-14 Piperazine derivatives
AT0891177A AT363090B (de) 1976-12-14 1977-12-14 Verfahren zur herstellung von neuen piperazinderivaten und deren salzen
YU02958/77A YU295877A (en) 1976-12-14 1977-12-14 Process for obtaining therepeutically active piperazine derivatives
DE19772755752 DE2755752A1 (de) 1976-12-14 1977-12-14 Piperazinderivate, verfahren zu ihrer herstellung und ihre verwendung
BE183456A BE861853A (fr) 1976-12-14 1977-12-14 Nouvelles piperazines
AU31573/77A AU516920B2 (en) 1976-12-14 1977-12-14 Piperazine derivatives
FI773786A FI69839C (fi) 1976-12-14 1977-12-14 Foerfarande foer framstaellning av terapeutiskt aktiva difenylmetoxialkylpiperazinderivat
ES465047A ES465047A1 (es) 1976-12-14 1977-12-14 Procedimiento para preparar derivados de piperazina
HU77GI266A HU177999B (en) 1976-12-14 1977-12-14 Process for producing new piperazine derivatives
LU78686A LU78686A1 (US07094801-20060822-C00212.png) 1976-12-14 1977-12-14
PT67400A PT67400B (en) 1976-12-14 1977-12-14 New chemical compounds
NL7713817A NL7713817A (nl) 1976-12-14 1977-12-14 Nieuwe, therapeutisch werkzame piperazinederiva- ten, werkwijzen ter bereiding hiervan en farma- ceutische preparaten die deze verbindingen be- vatten.
IT69793/77A IT1093045B (it) 1976-12-14 1977-12-14 Derivati piperazinici terapeuticamente attivi procedimento per la loro preparazione e composizioni farmaceutiche contenenti tali derivati
IE2541/77A IE46278B1 (en) 1976-12-14 1977-12-14 Piperazine derivatives
FR7737708A FR2374318A1 (en) 1976-12-14 1977-12-14 1-Benzhydryl:oxy-alkyl-4-phenylalkyl- or cinnamyl-piperazine derivs. - with dopaminergic, anticholinergic and antiparkinson activity (BE 14.6.78)
US05/860,460 US4202896A (en) 1976-12-14 1977-12-14 N-Benzhydryloxyethyl-N-phenylpropyl-piperazines
NO774307A NO148150C (no) 1976-12-14 1977-12-14 Analogifremstilling av terapeutisk aktive piperazinderivater
NZ185981A NZ185981A (en) 1976-12-14 1977-12-14 Piperazine derivatives and pharmaceutical compositions
SE7714184A SE435378B (sv) 1976-12-14 1977-12-14 1,4 disubstituerade piperazinderivat
ES473816A ES473816A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.
ES473814A ES473814A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.
ES473817A ES473817A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.
ES473818A ES473818A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.
ES473815A ES473815A1 (es) 1976-12-14 1978-09-29 Procedimiento para preparar derivados de piperazina.
US06/090,257 US4265894A (en) 1976-12-14 1979-11-01 Piperazine derivatives
AT712579A AT363095B (de) 1976-12-14 1979-11-06 Verfahren zur herstellung von neuen piperazinderivaten und deren salzen
AT712479A AT363094B (de) 1976-12-14 1979-11-06 Verfahren zur herstellung von neuen piperazinderivaten und deren salzen
AT712279A AT363092B (de) 1976-12-14 1979-11-06 Verfahren zur herstellung von neuen piperazinderivaten und deren salzen
AT712379A AT363093B (de) 1976-12-14 1979-11-06 Verfahren zur herstellung von neuen piperazinderivaten und deren salzen
YU189182A YU189182A (en) 1976-12-14 1982-08-23 Process for obtaining therapeutically active piperazine derivatives
YU189282A YU189282A (en) 1976-12-14 1982-08-23 Process for obtaining new therapeutically active piperazine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52223/76A GB1545094A (en) 1976-12-14 1976-12-14 Piperazine derivatives

Publications (1)

Publication Number Publication Date
GB1545094A true GB1545094A (en) 1979-05-02

Family

ID=10463103

Family Applications (1)

Application Number Title Priority Date Filing Date
GB52223/76A Expired GB1545094A (en) 1976-12-14 1976-12-14 Piperazine derivatives

Country Status (22)

Country Link
US (2) US4202896A (US07094801-20060822-C00212.png)
JP (1) JPS5382789A (US07094801-20060822-C00212.png)
AT (1) AT363090B (US07094801-20060822-C00212.png)
AU (1) AU516920B2 (US07094801-20060822-C00212.png)
BE (1) BE861853A (US07094801-20060822-C00212.png)
DE (1) DE2755752A1 (US07094801-20060822-C00212.png)
DK (1) DK147421C (US07094801-20060822-C00212.png)
ES (6) ES465047A1 (US07094801-20060822-C00212.png)
FI (1) FI69839C (US07094801-20060822-C00212.png)
GB (1) GB1545094A (US07094801-20060822-C00212.png)
HU (1) HU177999B (US07094801-20060822-C00212.png)
IE (1) IE46278B1 (US07094801-20060822-C00212.png)
IL (1) IL53597A0 (US07094801-20060822-C00212.png)
IT (1) IT1093045B (US07094801-20060822-C00212.png)
LU (1) LU78686A1 (US07094801-20060822-C00212.png)
NL (1) NL7713817A (US07094801-20060822-C00212.png)
NO (1) NO148150C (US07094801-20060822-C00212.png)
NZ (1) NZ185981A (US07094801-20060822-C00212.png)
PT (1) PT67400B (US07094801-20060822-C00212.png)
SE (1) SE435378B (US07094801-20060822-C00212.png)
YU (1) YU295877A (US07094801-20060822-C00212.png)
ZA (1) ZA777452B (US07094801-20060822-C00212.png)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001686A1 (en) * 1990-07-26 1992-02-06 Novo Nordisk A/S 1,4-disubstituted piperazines
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4492698A (en) * 1980-06-16 1985-01-08 Bjoerk Anders K Diphenylbutyl-1-acylpiperazines
NL8202636A (nl) * 1982-06-29 1984-01-16 Gist Brocades Nv Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten.
DE3600390A1 (de) * 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
US5162537A (en) * 1986-04-17 1992-11-10 Monsanto Company Benzhydryl compounds as herbicide antidotes
HU196194B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds
HU196196B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds
HU196195B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
FR2636946B1 (fr) * 1988-09-23 1990-11-02 Lipha ((diarylmethoxy)alcoyl)-1 pyrrolidines et piperidines, procedes de preparation et medicaments les contenant
US5153198A (en) * 1989-03-15 1992-10-06 Santen Pharmaceutical Co., Ltd. Agent for treatment of disorders of the cerebro-neural transmission system
US5087627A (en) * 1989-03-15 1992-02-11 Santen Pharmaceutical Co., Ltd. Agent for treatment of disorders of the cerebro-neural transmission system
FR2661176B1 (fr) * 1990-04-20 1992-06-12 Adir Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive.
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
JP3062249B2 (ja) * 1993-06-25 2000-07-10 ポーラ化成工業株式会社 ドーパミン再取込み阻害剤
DK1257541T3 (da) * 2000-01-11 2009-01-19 Molecular Insight Pharm Inc Farmakoforiske stoffer
US6743797B2 (en) * 2002-02-22 2004-06-01 Chantest, Inc. Methods for treating cardiac arrhythmia
US20050054010A1 (en) * 2003-07-15 2005-03-10 Brown Arthur M. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US7211407B2 (en) * 2003-07-15 2007-05-01 Chan Test, Inc. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US20050208595A1 (en) * 2004-03-19 2005-09-22 Brown Arthur M High throughput assay systems and methods for identifying agents that alter expression of cellular proteins
FR2884712B1 (fr) * 2005-04-21 2007-06-15 Oreal Compositions cosmetiques comprenant des derives de piperazine
EP2386554A1 (en) 2005-07-04 2011-11-16 High Point Pharmaceuticals, LLC Compounds active at the histamine H3 receptor
WO2007135111A1 (en) * 2006-05-23 2007-11-29 High Point Pharmaceuticals, Llc 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ' ] -bipyridine and its use as a medicament
EP2079732B9 (en) * 2006-05-29 2012-03-21 High Point Pharmaceuticals, LLC 3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
EP2014656A3 (en) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
US20120028992A1 (en) * 2010-08-02 2012-02-02 Brown Arthur M Pharmaceutical compositions for terminating acute episodes of cardiac arrhythmia, restoring sinus rhythm, preventing recurrence of cardiac arrhythmia and/or maintaining normal sinus rhythm in mammals
CN104529942B (zh) * 2014-12-10 2018-05-15 天津孚音生物科技发展有限公司 一种伐诺司林的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB837986A (en) 1956-07-10 1960-06-22 Henri Morren New piperazine derivatives and process for the preparation thereof
US2953568A (en) * 1958-03-03 1960-09-20 Ciba Pharm Prod Inc Derivatives of piperazine
CH410961A (de) * 1961-02-22 1966-04-15 Yoshitomi Pharmaceutical Verfahren zur Herstellung N-substituierter Piperazinderivate
DE1445692A1 (de) 1963-03-25 1969-03-20 Egyt Gyogyszervegyeszeti Gyar Verfahren zur Herstellung von Piperazinderivaten
DE1795375A1 (de) * 1968-09-21 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
JPS504086A (US07094801-20060822-C00212.png) * 1973-01-18 1975-01-16

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001686A1 (en) * 1990-07-26 1992-02-06 Novo Nordisk A/S 1,4-disubstituted piperazines
US5177077A (en) * 1990-07-26 1993-01-05 Novo Nordisk A/S 1,4-disubstituted piperazines
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines

Also Published As

Publication number Publication date
JPS5382789A (en) 1978-07-21
IL53597A0 (en) 1978-03-10
ES473817A1 (es) 1979-04-16
ES465047A1 (es) 1979-01-01
YU295877A (en) 1983-01-21
AT363090B (de) 1981-07-10
FI69839B (fi) 1985-12-31
DK147421C (da) 1985-02-11
DK147421B (da) 1984-07-30
HU177999B (en) 1982-02-27
PT67400B (en) 1979-05-21
ES473818A1 (es) 1979-04-16
DE2755752A1 (de) 1978-06-15
NO148150C (no) 1983-08-24
NZ185981A (en) 1980-02-21
NO774307L (no) 1978-06-15
AU516920B2 (en) 1981-07-02
IE46278B1 (en) 1983-04-20
NO148150B (no) 1983-05-09
US4265894A (en) 1981-05-05
AU3157377A (en) 1979-06-21
FI773786A (fi) 1978-06-15
ES473814A1 (es) 1979-04-16
SE7714184L (sv) 1978-06-15
ES473816A1 (es) 1979-04-16
JPS6215546B2 (US07094801-20060822-C00212.png) 1987-04-08
ZA777452B (en) 1978-10-25
BE861853A (fr) 1978-06-14
IE46278L (en) 1978-06-14
NL7713817A (nl) 1978-06-16
ATA891177A (de) 1980-12-15
US4202896A (en) 1980-05-13
PT67400A (en) 1978-01-01
IT1093045B (it) 1985-07-19
ES473815A1 (es) 1979-05-01
LU78686A1 (US07094801-20060822-C00212.png) 1978-04-17
DK557277A (da) 1978-06-15
FI69839C (fi) 1986-05-26
SE435378B (sv) 1984-09-24
DE2755752C2 (US07094801-20060822-C00212.png) 1991-12-05

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19931214