GB1389437A - 1,4-benzodiazepine derivatives and their preparation - Google Patents
1,4-benzodiazepine derivatives and their preparationInfo
- Publication number
- GB1389437A GB1389437A GB3413874A GB3413874A GB1389437A GB 1389437 A GB1389437 A GB 1389437A GB 3413874 A GB3413874 A GB 3413874A GB 3413874 A GB3413874 A GB 3413874A GB 1389437 A GB1389437 A GB 1389437A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- compounds
- preparation
- formula
- benzodiazepine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical class N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 2-pyrimidyl Chemical group 0.000 abstract 2
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 235000011054 acetic acid Nutrition 0.000 abstract 1
- 150000001243 acetic acids Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 239000003674 animal food additive Substances 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 150000004674 formic acids Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003326 hypnotic agent Substances 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- KLNFAMGHSZQYHR-UHFFFAOYSA-N imidazo[4,5-i][1,2]benzodiazepine Chemical class C1=CC=NN=C2C3=NC=NC3=CC=C21 KLNFAMGHSZQYHR-UHFFFAOYSA-N 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- BRMYZIKAHFEUFJ-UHFFFAOYSA-L mercury diacetate Chemical compound CC(=O)O[Hg]OC(C)=O BRMYZIKAHFEUFJ-UHFFFAOYSA-L 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940035363 muscle relaxants Drugs 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Animal Husbandry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16909171A | 1971-08-04 | 1971-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1389437A true GB1389437A (en) | 1975-04-03 |
Family
ID=22614230
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3413874A Expired GB1389437A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3412574A Expired GB1389436A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3288572A Expired GB1389434A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3412474A Expired GB1389435A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3412574A Expired GB1389436A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3288572A Expired GB1389434A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3412474A Expired GB1389435A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
Country Status (8)
| Country | Link |
|---|---|
| JP (3) | JPS5714351B1 (enrdf_load_stackoverflow) |
| AU (1) | AU461139B2 (enrdf_load_stackoverflow) |
| BE (1) | BE787251A (enrdf_load_stackoverflow) |
| CH (3) | CH591488A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2237592C2 (enrdf_load_stackoverflow) |
| FR (1) | FR2150732B1 (enrdf_load_stackoverflow) |
| GB (4) | GB1389437A (enrdf_load_stackoverflow) |
| ZA (1) | ZA724880B (enrdf_load_stackoverflow) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3917627A (en) * | 1971-08-04 | 1975-11-04 | Upjohn Co | 6-Substituted 4H-imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines and process for their production |
| FR2183716A1 (en) * | 1972-05-05 | 1973-12-21 | Centre Etd Ind Pharma | Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants |
| ZA755418B (en) * | 1974-09-11 | 1977-06-29 | Hoffmann La Roche | Diazepine derivatives |
| US3910946A (en) * | 1974-09-12 | 1975-10-07 | Upjohn Co | 4H-Imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines |
| CA1060892A (en) * | 1974-11-06 | 1979-08-21 | Parke, Davis And Company | Diazepine compounds and method for their production |
| AT361486B (de) * | 1975-08-07 | 1981-03-10 | Hoffmann La Roche | Verfahren zur herstellung von neuen imidazo(1,5 -a) (1,4)diazepinverbindungen, ihren salzen und optisch aktiven formen |
| US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
| AU6909194A (en) * | 1993-05-14 | 1994-12-12 | Board Of Regents, The University Of Texas System | Preparation of n-cyanodithioimino-carbonates and 3-mercapto-5-amino-1h-1,2,4-triazole |
| WO1996023790A1 (de) * | 1995-02-02 | 1996-08-08 | F. Hoffmann-La Roche Ag | Acetylimidazobenzodiazepine |
| JP6715830B2 (ja) | 2014-06-26 | 2020-07-01 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 過敏性腸症候群および末梢神経系の他の病気の治療のための末梢限局性ｇａｂａポジティブアロステリックモジュレーター |
| WO2018083051A1 (en) * | 2016-11-01 | 2018-05-11 | F. Hoffmann-La Roche Ag | 1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of cns related diseases |
| CN113717176B (zh) * | 2021-10-09 | 2022-07-05 | 上海再启生物技术有限公司 | 一种制备瑞马唑仑的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987052A (en) * | 1969-03-17 | 1976-10-19 | The Upjohn Company | 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
-
0
- BE BE787251D patent/BE787251A/xx not_active IP Right Cessation
-
1972
- 1972-07-13 GB GB3413874A patent/GB1389437A/en not_active Expired
- 1972-07-13 GB GB3412574A patent/GB1389436A/en not_active Expired
- 1972-07-13 GB GB3288572A patent/GB1389434A/en not_active Expired
- 1972-07-13 GB GB3412474A patent/GB1389435A/en not_active Expired
- 1972-07-14 ZA ZA724880A patent/ZA724880B/xx unknown
- 1972-07-18 AU AU44673/72A patent/AU461139B2/en not_active Expired
- 1972-07-28 CH CH1435675A patent/CH591488A5/xx not_active IP Right Cessation
- 1972-07-28 CH CH1435775A patent/CH584206A5/xx not_active IP Right Cessation
- 1972-07-28 CH CH1130272A patent/CH574444A5/xx not_active IP Right Cessation
- 1972-07-31 DE DE2237592A patent/DE2237592C2/de not_active Expired
- 1972-08-03 FR FR7228090A patent/FR2150732B1/fr not_active Expired
- 1972-08-04 JP JP7775772A patent/JPS5714351B1/ja active Pending
-
1979
- 1979-08-02 JP JP9817279A patent/JPS5547686A/ja active Granted
-
1980
- 1980-06-16 JP JP8030780A patent/JPS5726667A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| AU461139B2 (en) | 1975-05-15 |
| GB1389434A (en) | 1975-04-03 |
| GB1389436A (en) | 1975-04-03 |
| FR2150732A1 (enrdf_load_stackoverflow) | 1973-04-13 |
| JPS5547686A (en) | 1980-04-04 |
| CH591488A5 (enrdf_load_stackoverflow) | 1977-09-30 |
| BE787251A (fr) | 1973-02-05 |
| ZA724880B (en) | 1973-06-27 |
| CH584206A5 (enrdf_load_stackoverflow) | 1977-01-31 |
| FR2150732B1 (enrdf_load_stackoverflow) | 1976-04-16 |
| GB1389435A (en) | 1975-04-03 |
| DE2237592A1 (de) | 1973-02-15 |
| DE2237592C2 (de) | 1985-08-14 |
| AU4467372A (en) | 1974-01-24 |
| JPS5734277B2 (enrdf_load_stackoverflow) | 1982-07-22 |
| JPS5714351B1 (enrdf_load_stackoverflow) | 1982-03-24 |
| JPS5726667A (en) | 1982-02-12 |
| CH574444A5 (enrdf_load_stackoverflow) | 1976-04-15 |
| JPS5732066B2 (enrdf_load_stackoverflow) | 1982-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |