GB1373300A - Triazolobenzodiazepines and the manufacture thereof - Google Patents
Triazolobenzodiazepines and the manufacture thereofInfo
- Publication number
- GB1373300A GB1373300A GB3732172A GB3732172A GB1373300A GB 1373300 A GB1373300 A GB 1373300A GB 3732172 A GB3732172 A GB 3732172A GB 3732172 A GB3732172 A GB 3732172A GB 1373300 A GB1373300 A GB 1373300A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- triazolobenzodiazepines
- phch
- pyrryl
- pyrimidyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- -1 cyanomethyl Chemical group 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 239000003674 animal food additive Substances 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003326 hypnotic agent Substances 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 229940035363 muscle relaxants Drugs 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Fodder In General (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1373300 Triazolobenzodiazepines UPJOHN CO 10 Aug 1972 [8 Sept 1971] 37321/72 Heading C2C Triazolobenzodiazepines are prepared by the following routes (R 0 = C 1-3 alkyl, C 3-8 cycloalkyl, Ph, PhCH 2 , Py, pyrimidyl, pyrryl; R=H, C 1-3 alkyl, C 3-8 cycloalkyl, alkoxymethyl, alkylthiomethyl, dialkylaminomethyl, cyanomethyl, Ph, PhCH 2 , Py, pyrimidyl, pyrryl; R 1 =H, C 1-3 alkyl, OH, OOCH 3 , OOCC 2 H 5 ; R 2-5 =H, C 1-3 alkyl, CN, halogen, CF 3 , NO 2 , NH 2 , C 1-3 alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl or alkanoylamino, di(C 1-3 alkyl)amino; R 6 =C 1-3 alkyl), optionally followed by salt formation. Compounds IV and their salts are sedatives, tranquillizers, muscle relaxants, hypnotics and anticonvulsants and increase growth rate and feed efficiency of livestock. They may be administered in the form of pharmaceutical and veterinary preparations and feed additives containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17879171A | 1971-09-08 | 1971-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1373300A true GB1373300A (en) | 1974-11-06 |
Family
ID=22653964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3732172A Expired GB1373300A (en) | 1971-09-08 | 1972-08-10 | Triazolobenzodiazepines and the manufacture thereof |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS4834893A (en) |
| CH (1) | CH573940A5 (en) |
| DE (1) | DE2242059A1 (en) |
| FR (1) | FR2154475B1 (en) |
| GB (1) | GB1373300A (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5647911B2 (en) * | 1973-05-09 | 1981-11-12 | ||
| US4082761A (en) * | 1973-09-04 | 1978-04-04 | The Upjohn Company | Triazolo[4,3-a][1,4]benzodiazepinium quaternary salts |
| BR8004300A (en) * | 1979-12-03 | 1981-06-09 | American Can Co | CONTAINER |
| JPS5759754A (en) * | 1980-09-27 | 1982-04-10 | Matsushita Electric Works Ltd | Manufacture of composite veneer |
| JPS5839448A (en) * | 1981-09-02 | 1983-03-08 | 東洋鋼鈑株式会社 | Colored metallic plate coated with transparent thermoplastic resin film |
| JPS5886348U (en) * | 1981-12-07 | 1983-06-11 | 株式会社フジクラ | weather resistant colored composite |
| JPS59232852A (en) * | 1983-06-16 | 1984-12-27 | 東洋鋼鈑株式会社 | Metallic plate coated with printed polyester resin film |
| JPS61271066A (en) * | 1985-05-27 | 1986-12-01 | Hamada Mokuzai Kogyo Kk | Method for coating wooden plate |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987052A (en) * | 1969-03-17 | 1976-10-19 | The Upjohn Company | 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
| BE755139A (en) * | 1969-08-21 | 1971-02-22 | Upjohn Co | BENZODIAZEPINONES DERIVATIVES, THEIR INTERMEDIARIES, AND THEIR PREPARATION |
-
1972
- 1972-08-10 GB GB3732172A patent/GB1373300A/en not_active Expired
- 1972-08-26 DE DE2242059A patent/DE2242059A1/en active Pending
- 1972-09-05 CH CH1304372A patent/CH573940A5/xx not_active IP Right Cessation
- 1972-09-05 JP JP47088412A patent/JPS4834893A/ja active Pending
- 1972-09-07 FR FR7231733A patent/FR2154475B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH573940A5 (en) | 1976-03-31 |
| FR2154475B1 (en) | 1976-04-23 |
| JPS4834893A (en) | 1973-05-22 |
| DE2242059A1 (en) | 1973-03-15 |
| FR2154475A1 (en) | 1973-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |