GB1324318A - Triazolobenzodiazepines - Google Patents
TriazolobenzodiazepinesInfo
- Publication number
- GB1324318A GB1324318A GB1691472A GB1691472A GB1324318A GB 1324318 A GB1324318 A GB 1324318A GB 1691472 A GB1691472 A GB 1691472A GB 1691472 A GB1691472 A GB 1691472A GB 1324318 A GB1324318 A GB 1324318A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- triazolobenzodiazepines
- compounds
- formula
- rconhnh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1324318 Triazolobenzodiazepines UPJOHN CO 12 April 1972 [11 May 1971] 16914/72 Heading C2C Compounds of the general formula (R = H, C 1-3 alkyl, Ph, PhCH 2 , nitromethyl, cyanomethyl, C 2-4 alkoxymethyl, di(C 1-3 alkyl)- aminomethyl, C 2-4 alkylthiomethyl, pyrrolidinomethyl, C 2-4 alkoxycarbonyl; R 1 = H, C 1-3 alkyl; R 2 = pyridyl, 2-pyrimidyl, furyl, pyrryl, thienyl, C 1-3 alkyl, C 2-3 alkenyl, C 5-7 cycloalkyl or cycloalkenyl; R 3,4 = H, halogen, NO 2 , CF 3 , C 1-3 alkyl, alkoxy or alkylthio, di- (C 1-3 alkyl)amino) and their acid addition salts are prepared by reacting a compound of the formula with RCONHNH 2 , optionally followed by salt formation. The preparation of the thiones is described. The above compounds are sedatives, hypnotics, anticonvulsants, tranquillizers and muscle relaxants, and increase growth rate and feed efficiency of livestock. They may be administered in the form of pharmaceutical or veterinary preparations or food premixes containing them in association with a carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14241971A | 1971-05-11 | 1971-05-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1324318A true GB1324318A (en) | 1973-07-25 |
Family
ID=22499772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1691472A Expired GB1324318A (en) | 1971-05-11 | 1972-04-12 | Triazolobenzodiazepines |
Country Status (9)
Country | Link |
---|---|
US (1) | US3734922A (en) |
JP (1) | JPS554110B1 (en) |
BE (1) | BE783272A (en) |
CH (1) | CH582179A5 (en) |
DE (1) | DE2220623C2 (en) |
FR (1) | FR2137714B1 (en) |
GB (1) | GB1324318A (en) |
NL (1) | NL7206301A (en) |
ZA (1) | ZA722627B (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3904641A (en) * | 1971-06-18 | 1975-09-09 | Yoshitomi Pharmaceutical | Triazolothienodiazepine compounds |
US3886174A (en) * | 1971-11-22 | 1975-05-27 | Upjohn Co | 1-Substituted-6-phenyl-4H-s-triazolo{8 4,3-a{9 {8 1,4{9 benzodiazepines |
US3879406A (en) * | 1972-07-13 | 1975-04-22 | Hoffmann La Roche | Preparation of triazolobenzodiazepines |
US4155913A (en) * | 1973-02-08 | 1979-05-22 | Hoffmann-La Roche Inc. | Thienotriazolodiazepine derivatives |
FR2220257A1 (en) * | 1973-03-09 | 1974-10-04 | Lipha | 5,6-Dihydro-(4H)-s-triazolo-(4,3-a) (1,5)benzodiazepines - as antiinflam-matory and analgesic agents without tranquillising effects |
IE41197B1 (en) * | 1973-05-29 | 1979-11-07 | Squibb & Sons Inc | 4h-s-triazolo (4,3-a)(1,5)benzodiazepin-5-ones |
US3995043A (en) * | 1974-05-13 | 1976-11-30 | The Upjohn Company | Composition and process |
US4455307A (en) * | 1982-01-04 | 1984-06-19 | The Upjohn Company | Antihypertensive use of triazolobenzodiazepines |
JPS591395U (en) * | 1982-06-25 | 1984-01-06 | 株式会社東芝 | Vertical iron storage case |
FR2591596B1 (en) * | 1985-12-13 | 1988-09-09 | Roussel Uclaf | NOVEL 4H-TRIAZOLO (4,3-A) (1,4) BENZODIAZEPINES, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM |
AU2021246833A1 (en) | 2020-03-31 | 2022-07-21 | F. Hoffmann-La Roche Ag | Benzodiazepine derivatives as GABA A gamma1 PAMS |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3987052A (en) * | 1969-03-17 | 1976-10-19 | The Upjohn Company | 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
DE1955349C2 (en) * | 1969-11-04 | 1982-01-28 | Takeda Chemical Industries, Ltd., Osaka | s-Triazolo [4,3-a] [1,4] benzodiazepines |
-
1971
- 1971-05-11 US US00142419A patent/US3734922A/en not_active Expired - Lifetime
-
1972
- 1972-04-12 GB GB1691472A patent/GB1324318A/en not_active Expired
- 1972-04-18 ZA ZA722627A patent/ZA722627B/en unknown
- 1972-04-27 DE DE2220623A patent/DE2220623C2/en not_active Expired
- 1972-05-08 JP JP4469072A patent/JPS554110B1/ja active Pending
- 1972-05-09 CH CH688772A patent/CH582179A5/xx not_active IP Right Cessation
- 1972-05-10 BE BE783272A patent/BE783272A/en not_active IP Right Cessation
- 1972-05-10 FR FR7216687A patent/FR2137714B1/fr not_active Expired
- 1972-05-10 NL NL7206301A patent/NL7206301A/xx active Search and Examination
Also Published As
Publication number | Publication date |
---|---|
DE2220623A1 (en) | 1972-11-16 |
NL7206301A (en) | 1972-11-14 |
CH582179A5 (en) | 1976-11-30 |
FR2137714B1 (en) | 1975-12-26 |
BE783272A (en) | 1972-11-10 |
US3734922A (en) | 1973-05-22 |
ZA722627B (en) | 1973-02-28 |
DE2220623C2 (en) | 1985-04-25 |
JPS554110B1 (en) | 1980-01-29 |
FR2137714A1 (en) | 1972-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |