GB1271302A - New pyridyl-oxadiazole derivatives and process for the preparation thereof and pharmaceutical compositions containing same - Google Patents
New pyridyl-oxadiazole derivatives and process for the preparation thereof and pharmaceutical compositions containing sameInfo
- Publication number
- GB1271302A GB1271302A GB09047/69A GB1904769A GB1271302A GB 1271302 A GB1271302 A GB 1271302A GB 09047/69 A GB09047/69 A GB 09047/69A GB 1904769 A GB1904769 A GB 1904769A GB 1271302 A GB1271302 A GB 1271302A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compositions
- spasmolytic
- agents
- pharmaceutical compositions
- april
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- OLBJUDUHXGRSBY-UHFFFAOYSA-N 4-pyridin-2-yloxadiazole Chemical class O1N=NC(C=2N=CC=CC=2)=C1 OLBJUDUHXGRSBY-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 239000000812 cholinergic antagonist Substances 0.000 abstract 3
- 230000002048 spasmolytic effect Effects 0.000 abstract 3
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 abstract 1
- -1 2-ethyl-4-pyridyl group Chemical group 0.000 abstract 1
- GNEIDVZJZCQSNX-UHFFFAOYSA-N 5-pyridin-2-yloxadiazole Chemical compound N1=NOC(C=2N=CC=CC=2)=C1 GNEIDVZJZCQSNX-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 239000003326 hypnotic agent Substances 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUCI000796 | 1968-04-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1271302A true GB1271302A (en) | 1972-04-19 |
Family
ID=10994349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB09047/69A Expired GB1271302A (en) | 1968-04-26 | 1969-04-14 | New pyridyl-oxadiazole derivatives and process for the preparation thereof and pharmaceutical compositions containing same |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3647809A (https=) |
| JP (1) | JPS4824394B1 (https=) |
| AT (2) | AT292727B (https=) |
| BE (1) | BE732131A (https=) |
| BR (1) | BR6908381D0 (https=) |
| CA (1) | CA954858A (https=) |
| CH (2) | CH540925A (https=) |
| DE (1) | DE1920037A1 (https=) |
| FR (1) | FR2007529B1 (https=) |
| GB (1) | GB1271302A (https=) |
| IL (1) | IL31990A (https=) |
| NL (1) | NL6906401A (https=) |
| NO (1) | NO124253B (https=) |
| PL (1) | PL79435B1 (https=) |
| SE (1) | SE368576B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0116708A1 (de) * | 1982-12-20 | 1984-08-29 | CASSELLA Aktiengesellschaft | Neue substituierte 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP0091726A3 (en) * | 1982-03-03 | 1985-05-15 | Sumitomo Chemical Company, Limited | 5-substituted 1,2,4-oxadiazole derivatives, their preparation and pharmaceutical compositions containing them |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3853893A (en) * | 1973-04-02 | 1974-12-10 | Squibb & Sons Inc | Anthelmintic 5-(pyridyl)-3-(isothiocyanophenyl) oxadiazoles |
| HU177086B (en) * | 1975-06-09 | 1981-07-28 | Eszakmagyar Vegyimuevek | Herbicide and fungicide preparation containing substituted 1,2,4-oxadiazolidin-3-one derivatives |
| US6660753B2 (en) * | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| EP1582519A3 (en) * | 1999-08-19 | 2005-12-21 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| NZ517221A (en) * | 1999-08-19 | 2004-01-30 | Nps Pharma Inc | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| CN1853630A (zh) * | 2001-02-21 | 2006-11-01 | Nps制药公司 | 杂多环化合物及其在亲代谢的谷氨酸受体拮抗剂中的应用 |
| AU2003264018A1 (en) | 2002-08-09 | 2004-02-25 | Astrazeneca Ab | Compounds having an activity at metabotropic glutamate receptors |
| WO2004091480A2 (en) * | 2003-04-09 | 2004-10-28 | Exelixis, Inc. | Tie-2 modulators and methods of use |
| US20060252741A1 (en) * | 2003-05-15 | 2006-11-09 | Colandrea Vincent J | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists |
| US20060189661A1 (en) * | 2003-11-03 | 2006-08-24 | Wagenen Bradford V | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| WO2005060961A2 (en) * | 2003-12-18 | 2005-07-07 | Astrazeneca Ab | Treatment of transient lower esophageal sphincter relaxations (tlesrs) and gastro-esophageal reflux disease (gerd) |
| JP4958560B2 (ja) * | 2003-12-24 | 2012-06-20 | プロシディオン・リミテッド | Ｇｐｃｒ受容体作動薬としてのヘテロ環誘導体 |
| WO2005077368A2 (en) * | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Treatment of gastro-esophageal reflux disease (gerd) |
| KR20080000622A (ko) * | 2005-04-26 | 2008-01-02 | 뉴로서치 에이/에스 | 신규한 옥사디아졸 유도체 및 이의 의학적 용도 |
| IL169855A (en) * | 2005-07-25 | 2014-05-28 | Elta Systems Ltd | A system and method for locating a receiver location |
| AR058439A1 (es) | 2005-07-26 | 2008-02-06 | Portela & Ca Sa | Derivados de nitrocatecol como inhibidores de comt. procesos de obtencion y composiciones farmaceuticas. |
| EP1845097A1 (en) * | 2006-04-10 | 2007-10-17 | Portela & Ca., S.A. | Oxadiazole derivatives as COMT inhibitors |
| TWI392671B (zh) * | 2006-09-07 | 2013-04-11 | Actelion Pharmaceuticals Ltd | 吡啶-４-基衍生物 |
| ES2400163T3 (es) * | 2006-09-08 | 2013-04-08 | Actelion Pharmaceuticals Ltd. | Derivados de piridil-3-ilo como agentes de inmunomodulación |
| EP2481410B1 (en) | 2007-01-31 | 2016-07-13 | BIAL - Portela & Ca., S.A. | Nitrocatechol derivates as COMT inhibitors administered with a specific dosage regime |
| PT2125797E (pt) * | 2007-03-16 | 2014-03-11 | Actelion Pharmaceuticals Ltd | Derivados aminopiridina como agonistas do receptor s1p1/edg1 |
| US8598208B2 (en) * | 2007-08-17 | 2013-12-03 | Actelion Pharmaceuticals Ltd. | Pyridine derivatives as S1P1/EDG1 receptor modulators |
| WO2009108077A2 (en) * | 2008-02-28 | 2009-09-03 | Bial - Portela & Ca., S.A. | Pharmaceutical composition for poorly soluble drugs |
| JP5411877B2 (ja) * | 2008-03-06 | 2014-02-12 | アクテリオン ファーマシューティカルズ リミテッド | ピリジン化合物 |
| HRP20130641T1 (en) * | 2008-03-07 | 2013-08-31 | Actelion Pharmaceuticals Ltd. | Pyridin-2-yl derivatives as immunomodulating agents |
| KR20110002462A (ko) | 2008-03-17 | 2011-01-07 | 바이알 - 포르텔라 앤드 씨에이 에스에이 | 5-[3-(2,5-디클로로-4,6-디메틸-1-옥시-피리딘-3-일)-[1,2,4]옥사디아졸-5-일]-3-나이트로벤젠-1,2-디올의 결정형 |
| SI2291080T1 (sl) | 2008-05-14 | 2015-11-30 | The Scripps Research Institute | Novi modulatorji sfingosinskih fosfatnih receptorjev |
| WO2010093650A2 (en) | 2009-02-10 | 2010-08-19 | Divergence, Inc. | Compositions and methods for controlling nematodes |
| AU2010231961B2 (en) * | 2009-04-01 | 2015-05-21 | Bial - Portela & Ca., S.A. | Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof |
| RU2550133C2 (ru) * | 2009-04-01 | 2015-05-10 | БИАЛ-ПОРТЕЛА энд КА., С.А. | Фармацевтические составы, включающие производные нитрокатехола, и способы их получения |
| CN102471328B (zh) | 2009-07-16 | 2015-04-01 | 埃科特莱茵药品有限公司 | 吡啶-4-基衍生物 |
| HRP20150919T1 (hr) | 2011-01-19 | 2015-09-25 | Actelion Pharmaceuticals Ltd. | Derivati 2-metoksi-piridin-4-ila |
| US20140045900A1 (en) | 2011-02-11 | 2014-02-13 | Bial-Portela & Ca, S.A. | Administration regime for nitrocatechols |
| WO2013089573A1 (en) | 2011-12-13 | 2013-06-20 | BIAL - PORTELA & Cª., S.A. | Chemical compound useful as intermediate for preparing a catechol-o-methyltransferase inhibitor |
| CA2901006A1 (en) * | 2013-02-15 | 2014-08-21 | Monsanto Technology Llc | 3,5-disubstituted-4,5-dihydro-1,2,4-oxadiazoles for controlling nematode pests |
| JP2018500300A (ja) | 2014-11-28 | 2018-01-11 | ノヴィファーマ，エス．アー． | パーキンソン病を遅延させるための医薬 |
| BR112017024785B1 (pt) | 2015-05-20 | 2022-05-17 | Idorsia Pharmaceuticals Ltd | Forma cristalina do composto (s)-3-{4-[5-(2-ciclopentil-6-metoxi-piridin-4-il)-[1,2,4] oxadiazol-3- il]-2-etil-6-metilfenoxi}-propano-1,2-diol, composição farmacêutica, e, uso |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL256329A (https=) * | 1959-09-29 | |||
| US3227725A (en) * | 1962-04-17 | 1966-01-04 | Union Carbide Corp | Certain 3,5-disubstituted 1,2,4-oxadiazole compounds |
-
1969
- 1969-04-08 IL IL31990A patent/IL31990A/xx unknown
- 1969-04-08 US US815520A patent/US3647809A/en not_active Expired - Lifetime
- 1969-04-14 GB GB09047/69A patent/GB1271302A/en not_active Expired
- 1969-04-18 AT AT375469A patent/AT292727B/de not_active IP Right Cessation
- 1969-04-18 AT AT815670A patent/AT292728B/de not_active IP Right Cessation
- 1969-04-19 DE DE19691920037 patent/DE1920037A1/de active Pending
- 1969-04-24 CH CH627569A patent/CH540925A/de not_active IP Right Cessation
- 1969-04-24 FR FR696912994A patent/FR2007529B1/fr not_active Expired
- 1969-04-24 CH CH1476972A patent/CH542232A/de not_active IP Right Cessation
- 1969-04-25 JP JP44032259A patent/JPS4824394B1/ja active Pending
- 1969-04-25 CA CA049,755A patent/CA954858A/en not_active Expired
- 1969-04-25 NL NL6906401A patent/NL6906401A/xx unknown
- 1969-04-25 SE SE05909/69A patent/SE368576B/xx unknown
- 1969-04-25 PL PL1969133199A patent/PL79435B1/pl unknown
- 1969-04-25 BE BE732131D patent/BE732131A/xx unknown
- 1969-04-25 NO NO1733/69A patent/NO124253B/no unknown
- 1969-04-25 BR BR208381/69A patent/BR6908381D0/pt unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0091726A3 (en) * | 1982-03-03 | 1985-05-15 | Sumitomo Chemical Company, Limited | 5-substituted 1,2,4-oxadiazole derivatives, their preparation and pharmaceutical compositions containing them |
| US4618617A (en) * | 1982-03-03 | 1986-10-21 | Sumitomo Chemical Company, Limited | Novel 5-substituted 1,2,4,-oxadiazole derivatives and preparation thereof |
| EP0116708A1 (de) * | 1982-12-20 | 1984-08-29 | CASSELLA Aktiengesellschaft | Neue substituierte 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US4558058A (en) * | 1982-12-20 | 1985-12-10 | Cassella Aktiengesellschaft | Substituted 1,4-dihydropyridines and their use as medicaments |
Also Published As
| Publication number | Publication date |
|---|---|
| CA954858A (en) | 1974-09-17 |
| FR2007529A1 (https=) | 1970-01-09 |
| BE732131A (https=) | 1969-10-01 |
| DE1920037A1 (de) | 1970-11-12 |
| BR6908381D0 (pt) | 1973-02-08 |
| NO124253B (https=) | 1972-03-27 |
| PL79435B1 (en) | 1975-06-30 |
| AT292728B (de) | 1971-09-10 |
| CH540925A (de) | 1973-08-31 |
| CH542232A (de) | 1973-11-15 |
| US3647809A (en) | 1972-03-07 |
| NL6906401A (https=) | 1969-10-28 |
| JPS4824394B1 (https=) | 1973-07-20 |
| IL31990A0 (en) | 1969-06-25 |
| FR2007529B1 (https=) | 1973-03-16 |
| SE368576B (https=) | 1974-07-08 |
| AT292727B (de) | 1971-09-10 |
| IL31990A (en) | 1974-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1271302A (en) | New pyridyl-oxadiazole derivatives and process for the preparation thereof and pharmaceutical compositions containing same | |
| GB1298771A (en) | Carboxylic esters of hydroxyphenylalkanolamines | |
| GB1034939A (en) | Isoxazole derivative and processes for its production | |
| GB1174411A (en) | Novel Benzothiophen Compounds, Compositions containing them and processes for their manufacture | |
| GB1456627A (en) | Pyridobenzodiazepinones | |
| ES484718A1 (es) | Un procedimiento para la preparacion de benzopiranos. | |
| GB1290881A (https=) | ||
| GB1141936A (en) | Improvements in or relating to benzimidazole derivatives | |
| GB1084150A (https=) | ||
| GB1291442A (en) | Adamantylamino-5,8-dihydronaphthyloxy-propanols and related compounds | |
| GB1351505A (en) | Terpene derivatives method for their preparation and applications thereof | |
| GB1252286A (https=) | ||
| GB1181967A (en) | Novel Picoline Derivatives and a Method for the Production Thereof | |
| GB1352392A (en) | Phenylisopropylamine derivatives | |
| GB1353486A (en) | Benzodiazepine derivatives | |
| ES363591A1 (es) | Un procedimiento para la produccion de derivados de fenile-tilamina. | |
| GB1138315A (en) | 2-amino-benzylamines | |
| GB1036420A (en) | Medicinally useful isoquinoline derivatives and pharmaceutical preparations containing same | |
| IE39042L (en) | Ergoline derivatives | |
| GB1181295A (en) | Improvements in or relating to Naphthalene Derivatives and the Manufacture Thereof | |
| GB1377610A (en) | 5-piperidine-4-spiro- oxazolidinones method for their preparation and applications thereof | |
| GB1484470A (en) | Pharmaceutical compositions | |
| IE34313L (en) | 2-hydroxy-5-aminobenzamides | |
| GB1171859A (en) | 00,11-Epoxy-10,11-Dihydro-5H-Dibenzo[a,d] Cycloheptene-5-Carboxamides | |
| GB1159430A (en) | New Derivatives of 11 H-Dibenzo[1,2,5] Triazepine and their Salts and process for the preparation thereof |