GB1101425A - New pyrimidine derivatives - Google Patents

New pyrimidine derivatives

Info

Publication number
GB1101425A
GB1101425A GB45685/63A GB4568563A GB1101425A GB 1101425 A GB1101425 A GB 1101425A GB 45685/63 A GB45685/63 A GB 45685/63A GB 4568563 A GB4568563 A GB 4568563A GB 1101425 A GB1101425 A GB 1101425A
Authority
GB
United Kingdom
Prior art keywords
formula
group
compounds
pyrimidine
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB45685/63A
Other languages
English (en)
Inventor
Gilbert Regnier
Roger Canevari
Michel Laubie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL127996D priority Critical patent/NL127996C/xx
Application filed by Science Union et Cie filed Critical Science Union et Cie
Priority to GB45685/63A priority patent/GB1101425A/en
Priority to DK548264AA priority patent/DK115995B/da
Priority to BE655431D priority patent/BE655431A/xx
Priority to CH1449364A priority patent/CH437310A/fr
Priority to DES94142A priority patent/DE1297610B/de
Priority to US410771A priority patent/US3299067A/en
Priority to NO155542A priority patent/NO115800B/no
Priority to SE13664/64A priority patent/SE322521B/xx
Priority to BR164358/64A priority patent/BR6464358D0/pt
Priority to NL6413349A priority patent/NL6413349A/xx
Priority to FI642416A priority patent/FI46163C/fi
Priority to FR995390A priority patent/FR1451232A/fr
Priority to AT979464A priority patent/AT255421B/de
Priority to ES0306226A priority patent/ES306226A1/es
Priority to FR5760A priority patent/FR4770M/fr
Publication of GB1101425A publication Critical patent/GB1101425A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB45685/63A 1963-11-19 1963-11-19 New pyrimidine derivatives Expired GB1101425A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
NL127996D NL127996C (en:Method) 1963-11-19
GB45685/63A GB1101425A (en) 1963-11-19 1963-11-19 New pyrimidine derivatives
DK548264AA DK115995B (da) 1963-11-19 1964-11-06 Fremgangsmåde til fremstilling af derivater af piperazinyl-pyrimidin såvel som disses syreadditionssalte.
BE655431D BE655431A (en:Method) 1963-11-19 1964-11-06
CH1449364A CH437310A (fr) 1963-11-19 1964-11-10 Procédé de préparation de nouveaux dérivés de la pyrimidine
DES94142A DE1297610B (de) 1963-11-19 1964-11-11 2-(4-Benzylpiperazino)-pyrimidinderivate
NO155542A NO115800B (en:Method) 1963-11-19 1964-11-12
US410771A US3299067A (en) 1963-11-19 1964-11-12 2-[1'-(benzyl and phenyl)-4'-piperazinyl]-pyrimidine derivatives
SE13664/64A SE322521B (en:Method) 1963-11-19 1964-11-12
BR164358/64A BR6464358D0 (pt) 1963-11-19 1964-11-16 Processo para o preparo de novos derivados da pirimidina
NL6413349A NL6413349A (en:Method) 1963-11-19 1964-11-17
FI642416A FI46163C (fi) 1963-11-19 1964-11-18 Menetelmä uusien, vasodilaattoreina ja tulehdusta estävinä aineina ter apeuttisesti tehokkaiden pyrimidiinijohdannaisten ja niiden additiosuo lojen valmistamiseksi.
FR995390A FR1451232A (fr) 1963-11-19 1964-11-18 Nouveaux dérivés de la pyrimidine et leur procédé de préparation
AT979464A AT255421B (de) 1963-11-19 1964-11-19 Verfahren zur Herstellung von neuen Pyrimidinderivaten
ES0306226A ES306226A1 (es) 1963-11-19 1964-11-19 Procedimiento de preparaciën de nuevos derivados de la pirimidina
FR5760A FR4770M (en:Method) 1963-11-19 1965-02-16

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB45685/63A GB1101425A (en) 1963-11-19 1963-11-19 New pyrimidine derivatives

Publications (1)

Publication Number Publication Date
GB1101425A true GB1101425A (en) 1968-01-31

Family

ID=10438157

Family Applications (1)

Application Number Title Priority Date Filing Date
GB45685/63A Expired GB1101425A (en) 1963-11-19 1963-11-19 New pyrimidine derivatives

Country Status (14)

Country Link
US (1) US3299067A (en:Method)
AT (1) AT255421B (en:Method)
BE (1) BE655431A (en:Method)
BR (1) BR6464358D0 (en:Method)
CH (1) CH437310A (en:Method)
DE (1) DE1297610B (en:Method)
DK (1) DK115995B (en:Method)
ES (1) ES306226A1 (en:Method)
FI (1) FI46163C (en:Method)
FR (1) FR4770M (en:Method)
GB (1) GB1101425A (en:Method)
NL (2) NL6413349A (en:Method)
NO (1) NO115800B (en:Method)
SE (1) SE322521B (en:Method)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005068437A1 (en) * 2004-01-16 2005-07-28 Novartis Ag 2, 4 - diaminopyrimidines and their use for inducing cardiomyogenesis

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US3980781A (en) * 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
GB1143167A (en) * 1967-01-25 1969-02-19 Ucb Sa Derivatives of pyrimidine
GB1369379A (en) * 1972-04-07 1974-10-09 Science Union & Cie Benzodioxole derivatives and processes for preparing them
US3919230A (en) * 1974-02-07 1975-11-11 Smithkline Corp {62 -Naphthylmethyl piperazinyl derivatives
US3988457A (en) * 1974-02-07 1976-10-26 Smithkline Corporation Novel compounds and compositions for treating Parkinson's disease
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
US4166852A (en) * 1974-08-09 1979-09-04 Produits Chimiques Ugine Kuhlmann Piperazino-pyrimidines and their use as spasmolytic agents
OA06083A (fr) * 1977-11-09 1981-06-30 Science Union & Cie Ste Franca Nouvelles pipérazines disubstituées, leurs procédés de préparation et les compositions pharmaceutiques les renfermant.
FR2519986A1 (fr) * 1982-01-21 1983-07-22 Adir Nouveaux derives de benzodioxine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
FR2539990A1 (fr) * 1983-01-28 1984-08-03 Sanofi Sa Composition pharmaceutique a action psychotrope dopaminergique contenant une 2-piperazinopyrimidine
US4605655A (en) * 1984-03-06 1986-08-12 Bristol-Myers Company Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
US4980350A (en) * 1988-02-25 1990-12-25 Merck & Co., Inc. Piperazinylalkylpyrimidines as hypoglycemic agents
EP0330263A1 (en) * 1988-02-25 1989-08-30 Merck & Co. Inc. Piperazinylalkylpyrimidines as hypoglycemic agents
US4994460A (en) * 1989-06-01 1991-02-19 Bristol-Myers Squibb Co. Agents for treatment of brain ischemia
US5859246A (en) * 1997-01-30 1999-01-12 Neurogen Corporation 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands
AU752008B2 (en) * 1997-09-29 2002-09-05 Aventis Pharmaceuticals Inc. Aminoalkylphenol derivatives and related compounds
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
EP1545519B1 (en) 2002-08-19 2011-03-23 Pfizer Inc. Combination therapy for hyperproliferative diseases
US7241891B2 (en) * 2004-03-29 2007-07-10 Chung-Shan Institute Of Science & Technology Method for the purification of Piribedil
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
EP2094643B1 (en) 2006-12-01 2012-02-29 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
CN101735201B (zh) * 2009-12-17 2012-05-30 宁夏康亚药业有限公司 一种吡贝地尔的制备方法
CN101830891A (zh) * 2010-05-18 2010-09-15 沈阳药科大学 一种吡贝地尔的制备方法
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
SG11201701315VA (en) 2014-08-28 2017-03-30 Asceneuron Sa Glycosidase inhibitors
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN108884078A (zh) 2016-02-25 2018-11-23 阿森纽荣股份公司 糖苷酶抑制剂
SG11201807012QA (en) 2016-02-25 2018-09-27 Asceneuron S A Acid addition salts of piperazine derivatives
US11612599B2 (en) 2016-02-25 2023-03-28 Asceneuron Sa Glycosidase inhibitors
EP3585783A2 (en) 2016-02-25 2020-01-01 Asceneuron SA Sulfoximine glycosidase inhibitors
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
CN106432212B (zh) * 2016-09-21 2019-01-11 苏州弘森药业股份有限公司 一种合成吡贝地尔的方法
CN107163032A (zh) * 2017-06-19 2017-09-15 太仓卡斯特姆新材料有限公司 一种高收率的吡贝地尔制备方法
CN107266429A (zh) * 2017-06-19 2017-10-20 太仓大唐化纤厂 一种高品质的吡贝地尔制备方法
CN107216318A (zh) * 2017-06-19 2017-09-29 太仓弘杉环保科技有限公司 一种吡贝地尔制备方法
CN107417674B (zh) * 2017-06-26 2020-12-29 苏州弘森药业股份有限公司 一种吡贝地尔的提纯方法
US11213525B2 (en) 2017-08-24 2022-01-04 Asceneuron Sa Linear glycosidase inhibitors
WO2019037861A1 (en) 2017-08-24 2019-02-28 Asceneuron S.A. ANNOTATED GLYCOSIDASE INHIBITORS
RU2737721C2 (ru) * 2017-12-15 2020-12-02 Алексей Георгиевич Александров Способ получения фармацевтической субстанции на основе пирибедила
WO2020039028A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Tetrahydro-benzoazepine glycosidase inhibitors
WO2020039029A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Spiro compounds as glycosidase inhibitors
MA53429A (fr) 2018-08-22 2022-03-30 Asceneuron Sa Sels d'addition d'acide succinate et fumarate de dérivés de pipérazine utiles en tant qu'inhibiteurs de glycosidase
US12016852B2 (en) 2018-08-22 2024-06-25 Asceneuron Sa Pyrrolidine glycosidase inhibitors
ES3007652T3 (en) 2019-01-18 2025-03-20 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluoromethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-one as pcsk9 inhibitor and methods of use thereof
US20220143042A1 (en) 2019-02-22 2022-05-12 Asceneuron Sa Fused glycosidase inhibitors

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NL72956C (en:Method) * 1947-11-12
DE942029C (de) * 1951-06-22 1956-04-26 American Cyanamid Co Verfahren zur Herstellung von neuen, in 1-Stellung substituierten 4-Aminopiperazinderivaten
US3078214A (en) * 1958-09-12 1963-02-19 Sandoz Ag Treatment of mental disturbances with esters of indoles
US2979508A (en) * 1959-10-12 1961-04-11 Paul A J Janssen Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines
US3141820A (en) * 1960-10-31 1964-07-21 Merck & Co Inc Coccidiosis control composition
BE618035A (en:Method) * 1961-05-26
US3144387A (en) * 1961-06-30 1964-08-11 Parke Davis & Co Anti-inflammatory compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005068437A1 (en) * 2004-01-16 2005-07-28 Novartis Ag 2, 4 - diaminopyrimidines and their use for inducing cardiomyogenesis

Also Published As

Publication number Publication date
FR4770M (en:Method) 1967-01-23
SE322521B (en:Method) 1970-04-13
NL127996C (en:Method)
BR6464358D0 (pt) 1973-07-26
NL6413349A (en:Method) 1965-05-20
NO115800B (en:Method) 1968-12-09
FI46163B (en:Method) 1972-10-02
ES306226A1 (es) 1965-03-01
DE1297610B (de) 1969-06-19
US3299067A (en) 1967-01-17
BE655431A (en:Method) 1965-05-06
DK115995B (da) 1969-12-01
CH437310A (fr) 1967-06-15
FI46163C (fi) 1973-01-10
AT255421B (de) 1967-07-10

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