FI46163C - Menetelmä uusien, vasodilaattoreina ja tulehdusta estävinä aineina ter apeuttisesti tehokkaiden pyrimidiinijohdannaisten ja niiden additiosuo lojen valmistamiseksi. - Google Patents

Menetelmä uusien, vasodilaattoreina ja tulehdusta estävinä aineina ter apeuttisesti tehokkaiden pyrimidiinijohdannaisten ja niiden additiosuo lojen valmistamiseksi.

Info

Publication number
FI46163C
FI46163C FI642416A FI241664A FI46163C FI 46163 C FI46163 C FI 46163C FI 642416 A FI642416 A FI 642416A FI 241664 A FI241664 A FI 241664A FI 46163 C FI46163 C FI 46163C
Authority
FI
Finland
Prior art keywords
vasodilators
preparation
therapeutically effective
addition salts
inflammatory agents
Prior art date
Application number
FI642416A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI46163B (en:Method
Inventor
Regnier
Canevari
Laubie
Original Assignee
Science Union & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union & Cie filed Critical Science Union & Cie
Publication of FI46163B publication Critical patent/FI46163B/fi
Application granted granted Critical
Publication of FI46163C publication Critical patent/FI46163C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI642416A 1963-11-19 1964-11-18 Menetelmä uusien, vasodilaattoreina ja tulehdusta estävinä aineina ter apeuttisesti tehokkaiden pyrimidiinijohdannaisten ja niiden additiosuo lojen valmistamiseksi. FI46163C (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB45685/63A GB1101425A (en) 1963-11-19 1963-11-19 New pyrimidine derivatives

Publications (2)

Publication Number Publication Date
FI46163B FI46163B (en:Method) 1972-10-02
FI46163C true FI46163C (fi) 1973-01-10

Family

ID=10438157

Family Applications (1)

Application Number Title Priority Date Filing Date
FI642416A FI46163C (fi) 1963-11-19 1964-11-18 Menetelmä uusien, vasodilaattoreina ja tulehdusta estävinä aineina ter apeuttisesti tehokkaiden pyrimidiinijohdannaisten ja niiden additiosuo lojen valmistamiseksi.

Country Status (14)

Country Link
US (1) US3299067A (en:Method)
AT (1) AT255421B (en:Method)
BE (1) BE655431A (en:Method)
BR (1) BR6464358D0 (en:Method)
CH (1) CH437310A (en:Method)
DE (1) DE1297610B (en:Method)
DK (1) DK115995B (en:Method)
ES (1) ES306226A1 (en:Method)
FI (1) FI46163C (en:Method)
FR (1) FR4770M (en:Method)
GB (1) GB1101425A (en:Method)
NL (2) NL6413349A (en:Method)
NO (1) NO115800B (en:Method)
SE (1) SE322521B (en:Method)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980781A (en) * 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
GB1143167A (en) * 1967-01-25 1969-02-19 Ucb Sa Derivatives of pyrimidine
GB1369379A (en) * 1972-04-07 1974-10-09 Science Union & Cie Benzodioxole derivatives and processes for preparing them
US3919230A (en) * 1974-02-07 1975-11-11 Smithkline Corp {62 -Naphthylmethyl piperazinyl derivatives
US3988457A (en) * 1974-02-07 1976-10-26 Smithkline Corporation Novel compounds and compositions for treating Parkinson's disease
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
US4166852A (en) * 1974-08-09 1979-09-04 Produits Chimiques Ugine Kuhlmann Piperazino-pyrimidines and their use as spasmolytic agents
OA06083A (fr) * 1977-11-09 1981-06-30 Science Union & Cie Ste Franca Nouvelles pipérazines disubstituées, leurs procédés de préparation et les compositions pharmaceutiques les renfermant.
FR2519986A1 (fr) * 1982-01-21 1983-07-22 Adir Nouveaux derives de benzodioxine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
FR2539990A1 (fr) * 1983-01-28 1984-08-03 Sanofi Sa Composition pharmaceutique a action psychotrope dopaminergique contenant une 2-piperazinopyrimidine
US4605655A (en) * 1984-03-06 1986-08-12 Bristol-Myers Company Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
US4980350A (en) * 1988-02-25 1990-12-25 Merck & Co., Inc. Piperazinylalkylpyrimidines as hypoglycemic agents
EP0330263A1 (en) * 1988-02-25 1989-08-30 Merck & Co. Inc. Piperazinylalkylpyrimidines as hypoglycemic agents
US4994460A (en) * 1989-06-01 1991-02-19 Bristol-Myers Squibb Co. Agents for treatment of brain ischemia
US5859246A (en) * 1997-01-30 1999-01-12 Neurogen Corporation 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands
AU752008B2 (en) * 1997-09-29 2002-09-05 Aventis Pharmaceuticals Inc. Aminoalkylphenol derivatives and related compounds
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
EP1545519B1 (en) 2002-08-19 2011-03-23 Pfizer Inc. Combination therapy for hyperproliferative diseases
US20050209231A1 (en) * 2004-01-16 2005-09-22 Xu Wu Compositions and methods for inducing cardiomyogenesis
US7241891B2 (en) * 2004-03-29 2007-07-10 Chung-Shan Institute Of Science & Technology Method for the purification of Piribedil
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
EP2094643B1 (en) 2006-12-01 2012-02-29 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
CN101735201B (zh) * 2009-12-17 2012-05-30 宁夏康亚药业有限公司 一种吡贝地尔的制备方法
CN101830891A (zh) * 2010-05-18 2010-09-15 沈阳药科大学 一种吡贝地尔的制备方法
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
SG11201701315VA (en) 2014-08-28 2017-03-30 Asceneuron Sa Glycosidase inhibitors
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN108884078A (zh) 2016-02-25 2018-11-23 阿森纽荣股份公司 糖苷酶抑制剂
SG11201807012QA (en) 2016-02-25 2018-09-27 Asceneuron S A Acid addition salts of piperazine derivatives
US11612599B2 (en) 2016-02-25 2023-03-28 Asceneuron Sa Glycosidase inhibitors
EP3585783A2 (en) 2016-02-25 2020-01-01 Asceneuron SA Sulfoximine glycosidase inhibitors
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
CN106432212B (zh) * 2016-09-21 2019-01-11 苏州弘森药业股份有限公司 一种合成吡贝地尔的方法
CN107163032A (zh) * 2017-06-19 2017-09-15 太仓卡斯特姆新材料有限公司 一种高收率的吡贝地尔制备方法
CN107266429A (zh) * 2017-06-19 2017-10-20 太仓大唐化纤厂 一种高品质的吡贝地尔制备方法
CN107216318A (zh) * 2017-06-19 2017-09-29 太仓弘杉环保科技有限公司 一种吡贝地尔制备方法
CN107417674B (zh) * 2017-06-26 2020-12-29 苏州弘森药业股份有限公司 一种吡贝地尔的提纯方法
US11213525B2 (en) 2017-08-24 2022-01-04 Asceneuron Sa Linear glycosidase inhibitors
WO2019037861A1 (en) 2017-08-24 2019-02-28 Asceneuron S.A. ANNOTATED GLYCOSIDASE INHIBITORS
RU2737721C2 (ru) * 2017-12-15 2020-12-02 Алексей Георгиевич Александров Способ получения фармацевтической субстанции на основе пирибедила
WO2020039028A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Tetrahydro-benzoazepine glycosidase inhibitors
WO2020039029A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Spiro compounds as glycosidase inhibitors
MA53429A (fr) 2018-08-22 2022-03-30 Asceneuron Sa Sels d'addition d'acide succinate et fumarate de dérivés de pipérazine utiles en tant qu'inhibiteurs de glycosidase
US12016852B2 (en) 2018-08-22 2024-06-25 Asceneuron Sa Pyrrolidine glycosidase inhibitors
ES3007652T3 (en) 2019-01-18 2025-03-20 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluoromethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-one as pcsk9 inhibitor and methods of use thereof
US20220143042A1 (en) 2019-02-22 2022-05-12 Asceneuron Sa Fused glycosidase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL72956C (en:Method) * 1947-11-12
DE942029C (de) * 1951-06-22 1956-04-26 American Cyanamid Co Verfahren zur Herstellung von neuen, in 1-Stellung substituierten 4-Aminopiperazinderivaten
US3078214A (en) * 1958-09-12 1963-02-19 Sandoz Ag Treatment of mental disturbances with esters of indoles
US2979508A (en) * 1959-10-12 1961-04-11 Paul A J Janssen Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines
US3141820A (en) * 1960-10-31 1964-07-21 Merck & Co Inc Coccidiosis control composition
BE618035A (en:Method) * 1961-05-26
US3144387A (en) * 1961-06-30 1964-08-11 Parke Davis & Co Anti-inflammatory compositions

Also Published As

Publication number Publication date
FR4770M (en:Method) 1967-01-23
SE322521B (en:Method) 1970-04-13
NL127996C (en:Method)
BR6464358D0 (pt) 1973-07-26
NL6413349A (en:Method) 1965-05-20
NO115800B (en:Method) 1968-12-09
FI46163B (en:Method) 1972-10-02
ES306226A1 (es) 1965-03-01
DE1297610B (de) 1969-06-19
US3299067A (en) 1967-01-17
BE655431A (en:Method) 1965-05-06
DK115995B (da) 1969-12-01
CH437310A (fr) 1967-06-15
GB1101425A (en) 1968-01-31
AT255421B (de) 1967-07-10

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