GB1041279A - 13-alkyl steroid ketones - Google Patents
13-alkyl steroid ketonesInfo
- Publication number
- GB1041279A GB1041279A GB37618/61A GB3761861A GB1041279A GB 1041279 A GB1041279 A GB 1041279A GB 37618/61 A GB37618/61 A GB 37618/61A GB 3761861 A GB3761861 A GB 3761861A GB 1041279 A GB1041279 A GB 1041279A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- steroid
- formula
- ethylenic bond
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003431 steroids Chemical class 0.000 abstract 12
- -1 methoxy, ethoxy, methoxymethoxy Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000001590 oxidative effect Effects 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 150000001340 alkali metals Chemical class 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- 239000005977 Ethylene Substances 0.000 abstract 1
- 229910000564 Raney nickel Inorganic materials 0.000 abstract 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229940124325 anabolic agent Drugs 0.000 abstract 1
- 239000003263 anabolic agent Substances 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002524 organometallic group Chemical group 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A43—FOOTWEAR
- A43B—CHARACTERISTIC FEATURES OF FOOTWEAR; PARTS OF FOOTWEAR
- A43B3/00—Footwear characterised by the shape or the use
- A43B3/12—Sandals; Strap guides thereon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Woven Fabrics (AREA)
- Phenolic Resins Or Amino Resins (AREA)
- Manufacturing Of Printed Wiring (AREA)
Priority Applications (40)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB37618/61A GB1041279A (en) | 1961-10-19 | 1961-10-19 | 13-alkyl steroid ketones |
| GB37617/61A GB1041278A (en) | 1961-10-19 | 1961-10-19 | 13-alkyl steroid ketone derivatives |
| SE11023/62A SE312551B (enrdf_load_stackoverflow) | 1961-10-19 | 1962-10-15 | |
| SE11026/62A SE313809B (enrdf_load_stackoverflow) | 1961-10-19 | 1962-10-15 | |
| SE01423/67A SE335526B (enrdf_load_stackoverflow) | 1961-10-19 | 1962-10-15 | |
| SE11025/62A SE312553B (enrdf_load_stackoverflow) | 1961-10-19 | 1962-10-15 | |
| SE11024/62A SE312552B (enrdf_load_stackoverflow) | 1961-10-19 | 1962-10-15 | |
| CH1217162A CH450407A (de) | 1961-10-19 | 1962-10-17 | Verfahren zur Herstellung von 13-homologisierten Steroid-Ketonen |
| CH1275267A CH459195A (de) | 1961-10-19 | 1962-10-17 | Verfahren zur Herstellung von 13-Alkyl-steroid-diolen |
| CH1562666A CH450408A (de) | 1961-10-19 | 1962-10-17 | Verfahren zur Herstellung von Steroid-Ketonen |
| CH1562566A CH455763A (de) | 1961-10-19 | 1962-10-17 | Verfahren zur Herstellung von Steroid-Ketonen |
| DK448162AA DK113641B (da) | 1961-10-19 | 1962-10-17 | Fremgangsmåde til fremstilling af steroidketoner. |
| CH1562766A CH432509A (de) | 1961-10-19 | 1962-10-17 | Verfahren zur Herstellung von Steroid-Ketonen |
| DE1962S0082099 DE1468604C2 (de) | 1961-10-19 | 1962-10-18 | Verfahren zur Herstellung von 17alpha-Alkyl-,-Alkenyl- oder -Alkinyl-13beta-alkylgon-4-oder-5(10)-en-17beta-ol-3-onen |
| NO146140A NO122643B (enrdf_load_stackoverflow) | 1961-10-19 | 1962-10-18 | |
| DE19621618855 DE1618855B2 (de) | 1961-10-19 | 1962-10-18 | Gonanen-3,17-diole und verfahren zu ihrer herstellung |
| FI1878/62A FI41026B (enrdf_load_stackoverflow) | 1961-10-19 | 1962-10-18 | |
| DK449562AA DK121228B (da) | 1961-10-19 | 1962-10-18 | Analogifremgangsmåde til fremstilling af umættede steroidketoner. |
| ES281669A ES281669A1 (es) | 1961-10-19 | 1962-10-18 | Un procedimiento para preparar una cetona esteroide |
| NO146143A NO122646B (enrdf_load_stackoverflow) | 1961-10-19 | 1962-10-18 | |
| AT822762A AT264730B (de) | 1961-10-19 | 1962-10-18 | Verfahren zur Herstellung von neuen Steroidketonen |
| NO146141A NO122644B (enrdf_load_stackoverflow) | 1961-10-19 | 1962-10-18 | |
| DE19621793608 DE1793608B1 (de) | 1961-10-19 | 1962-10-18 | 17alpha-Alkyl-,-Alkenyl- oder -Alkinyl-13ss-alkylgon-4-oder-5(10)-en-17ss-ol-3-one |
| DE19621793595 DE1793595C3 (de) | 1961-10-19 | 1962-10-18 | Zwischenprodukte zur Herstellung von 17 alpha-Alkyl-, -Alkenyl- oder -Alkinyl-13 beta-alkylgon-4- oder -5(10)-en-17 beta-ol-3-onen |
| DK449662AA DK115549B (da) | 1961-10-19 | 1962-10-18 | Fremgangsmåde til fremstilling af umættede steroidketoner. |
| FI1879/62A FI41027B (enrdf_load_stackoverflow) | 1961-10-19 | 1962-10-18 | |
| DK449762AA DK115621B (da) | 1961-10-19 | 1962-10-18 | Fremgangsmåde til fremstilling af umættede steroidketoner. |
| FI1876/62A FI41024B (enrdf_load_stackoverflow) | 1961-10-19 | 1962-10-18 | |
| DE1962S0111837 DE1617818B2 (de) | 1961-10-19 | 1962-10-18 | Oral verabreichbare oder injizierbare antikonzeptionsmittel |
| NO146142A NO122645B (enrdf_load_stackoverflow) | 1961-10-19 | 1962-10-18 | |
| FI1877/62A FI41025B (enrdf_load_stackoverflow) | 1961-10-19 | 1962-10-18 | |
| AT825862A AT256356B (de) | 1961-10-19 | 1962-10-19 | Verfahren zur Herstellung von neuen 17-Alkyl-steroidketonen |
| AT825762A AT256355B (de) | 1961-10-19 | 1962-10-19 | Verfahren zur Herstellung von neuen ungesättigten 17-Alkylsteroidketonen |
| AT825662A AT256354B (de) | 1961-10-19 | 1962-10-19 | Verfahren zur Herstellung von neuen ungesättigten Steroidketonen |
| FR921556A FR2796M (fr) | 1961-10-19 | 1963-01-16 | Médicaments nouveaux constitués par des cétostéroides apparentés a la 19-nortestostérone. |
| SE05984/66A SE340619B (enrdf_load_stackoverflow) | 1961-10-19 | 1966-05-02 | |
| CY42968A CY429A (en) | 1961-10-19 | 1968-01-15 | 13-Alkyl steroid ketones |
| MY196875A MY6800075A (en) | 1961-10-19 | 1968-12-31 | 13-alkyl steroid ketones |
| DK227069AA DK129652B (da) | 1961-10-19 | 1969-04-24 | 17-Carbonhydrid-substituerede 3,17-dihydroxy-13-alkyl-gonener til anvendelse som mellemprodukter ved fremstilling af farmakologisk aktive, tilsvarende 17-carbonhydrid-substituerede 3-oxo-17-hydroxy-13-alkyl-gon-4- eller -5(10)-ener. |
| DK339670AA DK124753B (da) | 1961-10-19 | 1970-06-30 | Analogifremgangsmåde til fremstilling af 13-alkyl-gonen-3,17-dioler. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB37618/61A GB1041279A (en) | 1961-10-19 | 1961-10-19 | 13-alkyl steroid ketones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1041279A true GB1041279A (en) | 1966-09-01 |
Family
ID=10397775
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB37618/61A Expired GB1041279A (en) | 1961-10-19 | 1961-10-19 | 13-alkyl steroid ketones |
| GB37617/61A Expired GB1041278A (en) | 1961-10-19 | 1961-10-19 | 13-alkyl steroid ketone derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB37617/61A Expired GB1041278A (en) | 1961-10-19 | 1961-10-19 | 13-alkyl steroid ketone derivatives |
Country Status (12)
| Country | Link |
|---|---|
| AT (4) | AT264730B (enrdf_load_stackoverflow) |
| CH (5) | CH450408A (enrdf_load_stackoverflow) |
| CY (1) | CY429A (enrdf_load_stackoverflow) |
| DE (4) | DE1618855B2 (enrdf_load_stackoverflow) |
| DK (6) | DK113641B (enrdf_load_stackoverflow) |
| ES (1) | ES281669A1 (enrdf_load_stackoverflow) |
| FI (4) | FI41024B (enrdf_load_stackoverflow) |
| FR (1) | FR2796M (enrdf_load_stackoverflow) |
| GB (2) | GB1041279A (enrdf_load_stackoverflow) |
| MY (1) | MY6800075A (enrdf_load_stackoverflow) |
| NO (4) | NO122645B (enrdf_load_stackoverflow) |
| SE (6) | SE313809B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11617751B2 (en) | 2006-07-06 | 2023-04-04 | Bayer Pharma AG | Pharmaceutical composition containing a tetrahydrofolic acid |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2636404C2 (de) * | 1976-08-12 | 1983-12-08 | Schering AG, 1000 Berlin und 4709 Bergkamen | Δ↑1↑↑5↑-17α-Äthinylsteroide der Östranreihe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Präparate |
| CN104926906B (zh) * | 2015-06-04 | 2016-02-10 | 保定北瑞甾体生物有限公司 | 一种17α-羟基黄体酮的制备方法 |
-
1961
- 1961-10-19 GB GB37618/61A patent/GB1041279A/en not_active Expired
- 1961-10-19 GB GB37617/61A patent/GB1041278A/en not_active Expired
-
1962
- 1962-10-15 SE SE11026/62A patent/SE313809B/xx unknown
- 1962-10-15 SE SE11024/62A patent/SE312552B/xx unknown
- 1962-10-15 SE SE11023/62A patent/SE312551B/xx unknown
- 1962-10-15 SE SE01423/67A patent/SE335526B/xx unknown
- 1962-10-15 SE SE11025/62A patent/SE312553B/xx unknown
- 1962-10-17 CH CH1562666A patent/CH450408A/de unknown
- 1962-10-17 DK DK448162AA patent/DK113641B/da unknown
- 1962-10-17 CH CH1562566A patent/CH455763A/de unknown
- 1962-10-17 CH CH1275267A patent/CH459195A/de unknown
- 1962-10-17 CH CH1217162A patent/CH450407A/de unknown
- 1962-10-17 CH CH1562766A patent/CH432509A/de unknown
- 1962-10-18 AT AT822762A patent/AT264730B/de active
- 1962-10-18 NO NO146142A patent/NO122645B/no unknown
- 1962-10-18 DK DK449762AA patent/DK115621B/da unknown
- 1962-10-18 DE DE19621618855 patent/DE1618855B2/de active Granted
- 1962-10-18 DE DE1962S0111837 patent/DE1617818B2/de active Granted
- 1962-10-18 FI FI1876/62A patent/FI41024B/fi active
- 1962-10-18 FI FI1878/62A patent/FI41026B/fi active
- 1962-10-18 ES ES281669A patent/ES281669A1/es not_active Expired
- 1962-10-18 DE DE19621793608 patent/DE1793608B1/de active Pending
- 1962-10-18 DK DK449662AA patent/DK115549B/da unknown
- 1962-10-18 DK DK449562AA patent/DK121228B/da unknown
- 1962-10-18 NO NO146143A patent/NO122646B/no unknown
- 1962-10-18 NO NO146141A patent/NO122644B/no unknown
- 1962-10-18 DE DE1962S0082099 patent/DE1468604C2/de not_active Expired
- 1962-10-18 FI FI1877/62A patent/FI41025B/fi active
- 1962-10-18 NO NO146140A patent/NO122643B/no unknown
- 1962-10-18 FI FI1879/62A patent/FI41027B/fi active
- 1962-10-19 AT AT825762A patent/AT256355B/de active
- 1962-10-19 AT AT825662A patent/AT256354B/de active
- 1962-10-19 AT AT825862A patent/AT256356B/de active
-
1963
- 1963-01-16 FR FR921556A patent/FR2796M/fr not_active Expired
-
1966
- 1966-05-02 SE SE05984/66A patent/SE340619B/xx unknown
-
1968
- 1968-01-15 CY CY42968A patent/CY429A/xx unknown
- 1968-12-31 MY MY196875A patent/MY6800075A/xx unknown
-
1969
- 1969-04-24 DK DK227069AA patent/DK129652B/da unknown
-
1970
- 1970-06-30 DK DK339670AA patent/DK124753B/da unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11617751B2 (en) | 2006-07-06 | 2023-04-04 | Bayer Pharma AG | Pharmaceutical composition containing a tetrahydrofolic acid |
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