GB1014053A - 7-hydroxy-coumarin derivatives and process for their production - Google Patents
7-hydroxy-coumarin derivatives and process for their productionInfo
- Publication number
- GB1014053A GB1014053A GB30845/62A GB3084562A GB1014053A GB 1014053 A GB1014053 A GB 1014053A GB 30845/62 A GB30845/62 A GB 30845/62A GB 3084562 A GB3084562 A GB 3084562A GB 1014053 A GB1014053 A GB 1014053A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- radical
- alkyl
- compound
- aminoalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical class C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- -1 alkoxyalkyl radical Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- CJIJXIFQYOPWTF-UHFFFAOYSA-N 7-hydroxycoumarin Natural products O1C(=O)C=CC2=CC(O)=CC=C21 CJIJXIFQYOPWTF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005741 alkyl alkenyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical group 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEC24871A DE1186078B (de) | 1961-08-12 | 1961-08-12 | Verfahren zur Herstellung von Derivaten des 7-Oxy-cumarins |
| DEC25468A DE1210883B (de) | 1961-11-09 | 1961-11-09 | Verfahren zur Herstellung von Derivaten des 7-Oxycumarins |
| DEC0026091 | 1962-01-26 | ||
| DEC0026092 | 1962-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1014053A true GB1014053A (en) | 1965-12-22 |
Family
ID=27436691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB30845/62A Expired GB1014053A (en) | 1961-08-12 | 1962-08-10 | 7-hydroxy-coumarin derivatives and process for their production |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3282938A (enExample) |
| AT (1) | AT238716B (enExample) |
| CH (1) | CH415676A (enExample) |
| DK (1) | DK105069C (enExample) |
| FR (1) | FR1332328A (enExample) |
| GB (1) | GB1014053A (enExample) |
| NL (2) | NL6514403A (enExample) |
| SE (1) | SE303508B (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992022545A1 (en) * | 1991-06-14 | 1992-12-23 | Fidia S.P.A. | New coumarin derivatives |
| US5247099A (en) * | 1989-08-17 | 1993-09-21 | Abbott Laboratories | Process for synthesis of 7-hydroxy coumarins having substitutions in the 4-position |
| KR100638399B1 (ko) | 2005-06-09 | 2006-10-25 | 한국화학연구원 | 4-히드록시쿠마린 유사체의 제조방법 |
| WO2014018826A1 (en) | 2012-07-27 | 2014-01-30 | Sun Chemical Corporation | Ketocoumarins as photoinitiators and photosensitizers in inks |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1259349B (de) * | 1964-10-17 | 1968-01-25 | Cassella Farbwerke Mainkur Ag | Verfahren zur Herstellung von Derivaten des 7-Oxycumarins |
| US3515721A (en) * | 1967-06-26 | 1970-06-02 | Cassella Farbwerke Mainkur Ag | 3-tertiary-aminoethyl-4-methyl or phenyl-7-ethoxycarbonylmethoxy - halo or mononitro coumarins and congeners |
| US3625976A (en) * | 1969-12-09 | 1971-12-07 | Int Flavors & Fragrances Inc | Coumarin ether sun-screening compounds |
| US3859311A (en) * | 1972-02-25 | 1975-01-07 | Universal Oil Prod Co | Preparation of coumarins |
| IT1160365B (it) * | 1978-12-19 | 1987-03-11 | F I D I A Spa | Applicazioni in campo farmacologico e terapeutico dell'8-cloro-3-(beta-dietilamincetil)-4-metil-7-etossi-carbonilmetossicumarina cloridrato preparato allo stato puro mediante procedimento selettivo, con particolare riguardo alla sua azione antiaritmica |
| RS20050106A (sr) | 2002-08-19 | 2007-11-15 | Pfizer Products Inc., | Kombinovana terapija hiperproliferativnih bolesti |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| ATE547394T1 (de) | 2006-12-01 | 2012-03-15 | Bristol Myers Squibb Co | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
| JP5546451B2 (ja) | 2007-06-04 | 2014-07-09 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| HK1220696A1 (zh) | 2013-03-15 | 2017-05-12 | Bausch Health Ireland Limited | 鸟苷酸环化酶激动剂及其用途 |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| MX2015014666A (es) | 2013-04-17 | 2016-03-01 | Pfizer | Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares. |
| EP4424697A3 (en) | 2013-06-05 | 2024-12-25 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| US10703735B2 (en) * | 2018-07-25 | 2020-07-07 | Lead Discovery Center Gmbh | 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer |
| DK3911648T3 (da) | 2019-01-18 | 2025-01-13 | Astrazeneca Ab | 6'-[[(1s,3s)-3-[[5-(difluormethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-on som pcsk9-hæmmer og fremgangsmåder til anvendelse deraf |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2498497A (en) * | 1949-06-10 | 1950-02-21 | Sterling Drug Inc | 2[2(phthalimido)ethyl]pyridines |
| NL88205C (enExample) * | 1954-02-08 | |||
| US2980673A (en) * | 1954-10-14 | 1961-04-18 | Cutter Lab | Bis-quaternary ammonium esters of amino-carboxylic acids and aminoalcohols |
| US2844591A (en) * | 1955-10-14 | 1958-07-22 | Mead Johnson & Co | 1-substituted-3-pyrrolidylmethyl benzilates and salts thereof |
| US3074953A (en) * | 1962-01-17 | 1963-01-22 | American Home Prod | 5-(3'-(4-phenyl-4-carbethoxy piperidino)-propylidene) dibenzo (a,d) (1,4) cycloheptadiene |
-
0
- NL NL281975D patent/NL281975A/xx unknown
-
1962
- 1962-07-26 US US212657A patent/US3282938A/en not_active Expired - Lifetime
- 1962-08-10 FR FR906701A patent/FR1332328A/fr not_active Expired
- 1962-08-10 GB GB30845/62A patent/GB1014053A/en not_active Expired
- 1962-08-10 DK DK352962AA patent/DK105069C/da active
- 1962-08-10 AT AT649162A patent/AT238716B/de active
- 1962-08-10 SE SE8750/62A patent/SE303508B/xx unknown
- 1962-08-11 CH CH964862A patent/CH415676A/de unknown
-
1965
- 1965-11-05 NL NL6514403A patent/NL6514403A/xx unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5247099A (en) * | 1989-08-17 | 1993-09-21 | Abbott Laboratories | Process for synthesis of 7-hydroxy coumarins having substitutions in the 4-position |
| WO1992022545A1 (en) * | 1991-06-14 | 1992-12-23 | Fidia S.P.A. | New coumarin derivatives |
| KR100638399B1 (ko) | 2005-06-09 | 2006-10-25 | 한국화학연구원 | 4-히드록시쿠마린 유사체의 제조방법 |
| WO2014018826A1 (en) | 2012-07-27 | 2014-01-30 | Sun Chemical Corporation | Ketocoumarins as photoinitiators and photosensitizers in inks |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6514403A (enExample) | 1966-01-25 |
| CH415676A (de) | 1966-06-30 |
| SE303508B (enExample) | 1968-09-02 |
| DK105069C (da) | 1966-08-15 |
| AT238716B (de) | 1965-02-25 |
| US3282938A (en) | 1966-11-01 |
| NL281975A (enExample) | |
| FR1332328A (fr) | 1963-07-12 |
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