ES474155A1 - Un procedimiento para la preparacion de nuevos derivados de aminoalquilfurano - Google Patents

Un procedimiento para la preparacion de nuevos derivados de aminoalquilfurano

Info

Publication number
ES474155A1
ES474155A1 ES474155A ES474155A ES474155A1 ES 474155 A1 ES474155 A1 ES 474155A1 ES 474155 A ES474155 A ES 474155A ES 474155 A ES474155 A ES 474155A ES 474155 A1 ES474155 A1 ES 474155A1
Authority
ES
Spain
Prior art keywords
alkyl
image
carbon atoms
compounds
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES474155A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES474155A1 publication Critical patent/ES474155A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Un procedimiento para la preparación de nuevos derivados de aminoalquilfurano de fórmula general (*ver fórmula I) Y sus sales fisiológicamente aceptables y N-óxidos, hidratos y bioprecursores de los mismos, donde R1 y R2, que pueden ser iguales o diferentes, representan cada uno de ellos hidrógeno, alquilo C1-8, cicloalquilo C4-8, alquenilo C3-6, aralquilo de 1 a 4 átomos de carbono en el resto alquilo o alquilo C1-8 interrumpido por un átomo de óxigeno o un grupo donde R5 representa hidrógeno o alquilo C1-8 o bien R1 y R2 unidos junto con el átomo de nitrógeno al que están enlazados pueden formar un anillo heterocíclico monocíclico saturado, de 5 a 7 miembros, R5 representa alquilo C1-8 lineal o ramificado, alcoxialquilo de 1 a 8 átomos de carbono en cada resto alquyilo, hidroxialquilo C1-8, alcoxicarbonilo C1-8, alquiltioalquilo de 1 a 8 átomos de carbono en cada resto alquilo, halógeno o arilo; R4 representa hidrógeno, alquilo C1-8, alquenilo C3-6 o alcoxialquilo de 1 a 8 átomos de carbono en cada resto alquilo; X representa ¿O- o ¿S-; Y representa =S, =O, =NR6 o =CHNO2, donde R6 representa hidrógeno, nitro, ciano, alquilo c1-8, arilo, alquilsulfonilo C1-8 o arilsulfonilo; m representa un número entero de 2 a 4 inclusive y n representa un número entero que es 1 o 2 adicionalmente, cuando X es ¿S-, n también puede ser O.
ES474155A 1977-10-11 1978-10-11 Un procedimiento para la preparacion de nuevos derivados de aminoalquilfurano Expired ES474155A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4225677 1977-10-11

Publications (1)

Publication Number Publication Date
ES474155A1 true ES474155A1 (es) 1979-10-16

Family

ID=10423586

Family Applications (1)

Application Number Title Priority Date Filing Date
ES474155A Expired ES474155A1 (es) 1977-10-11 1978-10-11 Un procedimiento para la preparacion de nuevos derivados de aminoalquilfurano

Country Status (12)

Country Link
US (1) US4288443A (es)
EP (1) EP0001699B1 (es)
JP (1) JPS5461167A (es)
AU (1) AU524143B2 (es)
DE (1) DE2861646D1 (es)
DK (1) DK452578A (es)
ES (1) ES474155A1 (es)
FI (1) FI783098A (es)
IE (1) IE47401B1 (es)
IT (1) IT1109317B (es)
NZ (1) NZ188625A (es)
ZA (1) ZA785734B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
AU539733B2 (en) * 1979-10-23 1984-10-11 Glaxo Group Limited Thiophen derivatives
US4238487A (en) * 1979-10-31 1980-12-09 Merck & Co., Inc. Aminoalkyl benzofuran derivatives
YU53681A (en) * 1980-03-08 1983-12-31 Smith Kline French Lab Process for obtaining 5-dimethylamino-methyl-2-furane methanol
ES514937A0 (es) * 1981-08-14 1983-10-16 Chemistar Sa "procedimiento de preparar derivados del acido sulfamico y similares".
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
DE3343884A1 (de) * 1982-12-08 1984-06-14 Degussa Ag, 6000 Frankfurt Neue ethendiamin- und guanidin-derivate
HUT39739A (en) * 1984-12-04 1986-10-29 Ciba Geigy Ag Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
US4980371A (en) * 1988-12-21 1990-12-25 Merrell Dow Pharmaceuticals Antiretroviral furan ketones
US8006529B2 (en) 2003-09-12 2011-08-30 Dreamwell, Ltd. Methods for manufacturing coil springs
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB930506A (en) * 1958-12-30 1963-07-03 Merck & Co Inc Preparation of 5-aminomethyl-2-furfurylamine
FR1601575A (es) * 1968-12-03 1970-08-31
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives

Also Published As

Publication number Publication date
US4288443A (en) 1981-09-08
EP0001699B1 (en) 1982-02-24
IT1109317B (it) 1985-12-16
DE2861646D1 (en) 1982-03-25
JPS5461167A (en) 1979-05-17
AU4060478A (en) 1980-04-17
NZ188625A (en) 1981-03-16
DK452578A (da) 1979-04-12
EP0001699A3 (en) 1979-05-30
ZA785734B (en) 1979-09-26
IE47401B1 (en) 1984-03-07
EP0001699A2 (en) 1979-05-02
AU524143B2 (en) 1982-09-02
FI783098A (fi) 1979-04-12
JPS6249270B2 (es) 1987-10-19
IE782028L (en) 1979-04-11
IT7851459A0 (it) 1978-10-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001204